Spontaneous programmed cell death in infiltrating duct carcinoma: Association with p53, BCL-2, hormone receptors and tumor proliferation

Pathology Research and Practice

Volumn 194, Issue 8, 1998, Pages 549-557

  Pillai, M Radhakrishna ^a,b   Kesari, A Lakshmi ^a   Chellam, V G ^a   Madhavan, Jayaprakash ^a   Nair, Pradip ^a   Krishnan Nair, M ^a  

^a Medical College Hospital Thiruvananthapuram   (India)

^b REGIONAL CANCER CENTRE   (India)

Author keywords

Apoptosis; bcl 2; Breast cancer; p53; Proliferation

Indexed keywords

ESTROGEN RECEPTOR; KI 67 ANTIGEN; PROGESTERONE RECEPTOR; PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; APOPTOSIS; ARTICLE; BREAST CARCINOMA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; LYMPH NODE; MAJOR CLINICAL STUDY; TUMOR VOLUME;

EID: 0031715531     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(98)80044-7     Document Type: Article

References (29)

1. Barket J, Bartkova J, Voilesele B, Staskova Z, Refthar A, Kovari KJ (1990) Patterns of expression of the p53 tumor suppresor in human breast tissue and tumors in situ and in vitro. Int J Cancer 46: 839-844
2. Bloom HJC, Richardson WW (1957) Histological grading and prognosis in Breast cancer. A study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 11: 359-377
3. Davidoff AM, Humprey PA, Iglehart JD, Marks JR (1991) Genetic basis for p53 overexpression in human breast cancer. Proc Natcl Acad Sci USA 88: 5066-5011
4. Deppert W (1994) The yin and yang of p53 in cellular proliferation. Sem Cancer Biol 5: 187-202
5. Diebold J, Barelton G, Felchner M, Meier W, Dopfer K, Schmidt M (1996) Bcl-2 expression, p53 accumulation and apoptosis in ovarian carcinomas. Am J Clin Pathol 105: 341-349
6. Dive C, Wyllie AH (1992) Apoptosis and cancer chemotherapy. In: Hickman JA, Trilton TT (Eds) Blackwell Scientific Publications, Oxford
7. Elledge RM, Alfred DC (1994) The p53 Tumor suppressor gene in breast cancer. Breast Can Res Treat 32: 39-47
8. Ellis PA, Smith IE, Dowsett M (1996) Apoptosis - its role in tumor growth and therapy. Cytopathol 22: 132-135
9. Halder S, Negrini M, Monne M, Sabbioni S, Croce CM (1994) Down regulation of bcl-2 and p53 in breast cancer cells. Cancer Res 54: 2095-2097
10. Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M (1995) Induction of apoptosis in He La cells by trans-activation deficient p53. Genes-Dev 17: 2170-2183
11. Kerr JFR, Wyllie AH, Currie AR (1992) Apoptosis - a basic biological phenomenon with wide ranging implications in tissue kinetics. Brit J Cancer 26: 239-257
12. Kesari AL, Chellam VG, Nair PP, Madhavan J, Nair MK, Pillai MR (1997) Expression of the anti apoptotic protein bcl-2 is not dependent on the tumor suppressor p53 protein in indian breast carcinoma. Pathobiology 65: 108-112
13. Kesari AL, Chellam VG, Nair PP, Ahmed I, Madhavan J, Thomas PA (1997) p53 tumor suppressor protein and tis-sue proliferative fraction in infiltrating duct carcinoma. J of Surg Oncol 65: 159-163
14. Lewensohn-Fuchs I, Munck-wikland E, Berka Z, Magnusson KP (1994) Involvement of aberrant p53 expression and HPV in carcinoma of the head, neck and esophagus. Anticancer Research 14: 1281-1286
15. Linden MD, Torres FX, Kubus J, Zarbo RJ (1992) Clinical application of morphological and immunocytochemical assessments of cell proliferation. Am J Clin Pathol 97: 4-12
16. Martinez J, Georgoff I, Martinez J (1991) Cellular localization and cell cycle regulation by a temperature sensitive p53 protein. Genes Dev 5: 151-159
17. Me Donnel, Martin TJ, Brisbay MC, McConnel K, Tu S, Campbell M (1993) The bcl-2 oncogene, apoptosis and neoplasia. Radiat Res 136: 307-310
18. Merlino G (1994) Regulatory imbalances in cell proliferation and cell death during oncogenes in transgenic mice. Semin Cancer Biol 5: 13-20
19. Miyashita T, Harigai M, Hanada M, Reed JC (1994) Identification of a p53 dependent negative response element in the bcl2 gene. Cancer Res 54: 3131-3135
20. O'Neill AJ, Stauinton MJ, Gaffney EF (1996) Apoptosis occurs independently of bcl-2 and p53 overexpression in non small cell lung carcinoma. Histopathology 29: 5-50
21. Pillai MR, Halabi S, McKalip A, Jayaprakash PG, Rajalakshmi TN, Nair MK (1996) The presence of Human papillomavirus-16/18 E6, p53, and bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer. Cancer Epidemiol Biomarkers and Prev 5: 329-335
22. Ravi D, Nalinakumari KR, Rajaram RS, Nair MK, Pillai M R(1996) Expression of programmed cell death regulatory p53 and bcl-2 proteins in oral lesions. Can Lett 105: 139-146
23. Ravi D, Ramdas K, Mathew BS, Nalinakumari KR, Nair MK (1998) Angiogenesis during tumor progression in the oral cavity is related to reduced apoptosis and high tumor cell proliferation. Eur J Cancer Part II, Oral Oncol (in press)
24. Salvakumaran M, Lin HK, Miyashita T, Wang HG, Krayewski S, Reed JC (1994) Immediate early up regulation of bax expression by p53 but not TGF beta 1: a paradigm for distant apoptotic pathways. Oncogene 9: 1791-1798
25. Srinivas G, Kusumakumari P, Nair MK, Panicker KR, Pillai MR (1997) Tumor proliferative compartment, multi drug resistant gene product and apoptosis regulatory p53 and bcl-2 proteins in paediatric acute lymphoblastic leukaemia. Oncology Rep 4: 1083-1087
26. Steel GG (1977) Growth kinetics of tumors, pp 176-177. Clarendon Press, Oxford
27. Thor AD, Moore DH, Edgeston SM, Kawasaki Es, Reihsaus E, Lymch HT (1992) Accumulation of p53 tumor expressor gene protein an independent marker of prognosis in breast cancer. J Natl Cancer Inst 84: 845-855
28. Van den Berg FM, Bass IO, Polak MM, Offerhaus GJA (1993) Detection of p53 overexpression in routinely fixed paraffin embedded tissue of human carcinomas using a novel Targeting Unmasking Fluid. Am J Pathol 142: 381-385
29. Wyllie AH (1992) Apoptosis and the regulation of cell numbers in normal and neoplastic tissue an overview. Cancer Metast Rev 11: 141-148