Inhibition of renal 11β-hydroxysteroid dehydrogenase in vivo by carbenoxolone in the rat and its relationship to sodium excretion

Clinical Science

Volumn 95, Issue 4, 1998, Pages 435-443

  Sewell, K J ^a   Shirley, D G ^a   Michael, A E ^b   Thompson, A ^b   Norgate, D P ^b   Unwin, R J ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c MIDDLESEX HOSPITAL   (United Kingdom)

Author keywords

11 hydroxysteroid dehydrogenase; Carbenoxolone; Fractional sodium excretion; Glucocorticoids

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CARBENOXOLONE; CORTICOSTERONE; GLUCOCORTICOID; HYDROCORTISONE; LIVER ENZYME; MINERALOCORTICOID RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXOSTEROID; POTASSIUM ION; SODIUM ION; CORTISONE; ENZYME INHIBITOR; HYDROXYSTEROID DEHYDROGENASE; POTASSIUM; SODIUM; TRITIUM;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; ELECTROLYTE URINE LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; GLOMERULUS FILTRATION RATE; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FUNCTION; MALE; MEAN ARTERIAL PRESSURE; NEPHRON; NONHUMAN; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; RAT; SODIUM BLOOD LEVEL; SODIUM EXCRETION; SODIUM URINE LEVEL; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; KIDNEY; METABOLISM; SPRAGUE DAWLEY RAT; URINE;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CARBENOXOLONE; CORTISONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HYDROCORTISONE; HYDROXYSTEROID DEHYDROGENASES; KIDNEY; MALE; NAD; NADP; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; TRITIUM;

EID: 0031715395     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS19980157     Document Type: Article

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