A mutation in the prothrombin gene contributing to venous thrombosis during pregnancy

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 105, Issue 8, 1998, Pages 923-925

  McColl, M D ^a   Walker, I D ^a   Greer, I A ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLIPIN ANTIBODY; ENOXAPARIN; ETHINYLESTRADIOL PLUS NORGESTIMATE; HEPARIN; IMMUNOGLOBULIN M ANTIBODY; LUPUS ANTICOAGULANT; ORAL CONTRACEPTIVE AGENT; PROTEIN C; PROTHROMBIN; WARFARIN;

ADULT; ARTICLE; CASE REPORT; DOPPLER ECHOGRAPHY; FEMALE; GENE MUTATION; HUMAN; POLYMERASE CHAIN REACTION; PREGNANCY; PRIORITY JOURNAL; RISK FACTOR; URINARY TRACT INFECTION; VEIN THROMBOSIS;

ADULT; FEMALE; HETEROZYGOTE; HUMANS; MUTATION; POLYMERASE CHAIN REACTION; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PROTHROMBIN; THROMBOPHLEBITIS;

EID: 0031715289     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1998.tb10241.x     Document Type: Article

References (8)

1. McColl MD, Ramsay JE, Tait RC et al. Risk factors for pregnancy associated venous thromboembolism. Thromb Haemost 1997; 78: 1183–1188.
2. Poort SW, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698–3703.
3. Department of Health, Welsh Ofiice, Scottish Home and Health Department and Department of Health and Social Services, Northern Ireland. Confidential Enquiries into Maternal Deaths in the United Kingdom 1991-93. London: HMSO, 1996.
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7. Brown K, Luddington R, Williamson D, Baker P, Baglin T. Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3′-untranskdted region of the prothrombin gene. Br J Haematol 1997; 98:907–909.
8. Koster T, Rosendaal FR, De Ronde H, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342:1503–1506.