A mixture experiment approach for controlling the dissolution rate of a sustained-release tablet

Drug Development and Industrial Pharmacy

Volumn 24, Issue 9, 1998, Pages 799-806

  Geoffroy, Jean Marie ^a   Fredrickson, Jennifer K ^b   Shelton, John T ^c  

^a ABBOTT LABORATORIES   (United States)

^b Perrigo Company   (United States)

^c SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM PHOSPHATE; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; METHOCEL K100MCR PREMIUM; METHOCEL K4MCR PREMIUM; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; METHODOLOGY; MODEL; SUSTAINED RELEASE PREPARATION; TABLET;

EID: 0031714768     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.3109/03639049809088524     Document Type: Article

References (2)

1. T. Higuchi, Mechanism of sustained-action medication - Theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci., 52, 1145-1149 (1963).
2. J. A. Cornell, Experiments with Mixtures: Desings, Models, and the Analysis of Mixture Data, 2nd ed., John Wiley & Sons, Inc., New York, 1990, Chapters 4 and 7.