Prevention of herpes simplex virus infection and latency by prophylactic treatment with acyclovir in a weanling mouse model

American Journal of Obstetrics and Gynecology

Volumn 179, Issue 2, 1998, Pages 527-532

  Dobson, A T ^a   Little, B B ^a   Scott, L L ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Acyclovir prophylaxis; Herpes simplex virus; Mouse model

Indexed keywords

ACICLOVIR; BETA GALACTOSIDASE;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; HERPES SIMPLEX VIRUS; HERPES VIRUS INFECTION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROPHYLAXIS; VIRUS INHIBITION; VIRUS REPLICATION;

EID: 0031714530     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(98)70390-4     Document Type: Conference Paper

References (22)

1. CG. Prober Herpes simplex virus infections 20th ed AM Rudolph JIE Hoffman CD Rudolph Rudolphs pediatrics. 1996 Appleton and Lange Stamford (CT) 651
2. R Whitley A Arvin C Prober S Burchett L Corey D Powell A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection N Engl J Med 324 1991 444 449
3. LL Scott PJ Sanchez GL Jackson F Zeray GD. Wendel Acyclovir suppression to prevent cesarean delivery after first-episode genital herpes Obstet Gynecol 87 1996 69 73
4. B. Stray-Pedersen Acyclovir in late pregnancy to prevent neonatal herpes simplex Lancet 336 1990 756
5. KM Stone CA Brooks ME Guinan ER. Alexander National surveillance for neonatal herpes simplex virus infections Sex Transm Dis 16 1989 152 156
6. JR Lokensgard DC Bloom AT Dobson LT. Feldman Long-term promoter activity during herpes simplex virus latency J Virol 68 1994 7148 7158
7. AT Dobson F Sedarati G Devi-Rao WM Flanagan MJ Farrell JG Stevens Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus J Virol 63 1989 3844 3851
8. JG Stevens EK Wagner GB Devi-Rao ML Cook LT. Feldman RNA complimentary to a herpesvirus alpha gene mRNA is predominant in latently infected neurons Science 235 1987 1056 1059
9. HJ Field E. De Clercq Effects of oral treatment with acyclovir and bromovinyldeoxyuridine on the establishment and maintenance of latent herpes simplex virus infection in mice J Gen Virol 56 1981 259 265
10. TP Margolis F Sedarati AT Dobson LT Feldman JG. Stevens Pathways of viral gene expression during acute neuronal infection with HSV-1 Virology 189 1992 150 151
11. AT Dobson TP Margolis F Sedarati JG Stevens LT Feldman A latent, nonpathogenic HSV-1–derived vector stably expresses β-galactosidase in mouse neurons Neuron 5 1990 353 360
12. YJ Bryson M Dillon M Lovett G Acuna S Taylor JD Cherry Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir: a randomized double-blind controlled trial in normal subjects N Engl J Med 308 1983 916 921
13. GJ Mertz CW Critchlow J Benedetti RC Reichman R Dolin J Connor Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection JAMA 252 1984 1147 1151
14. RC Reichman GJ Badger GJ Mertz L Corey DD Richman JD Connor Treatment of recurrent genital herpes simplex infections with oral acyclovir: a controlled trial JAMA 251 1984 2103 2107
15. SE Straus KD Croen MH Sawyer AG Freifeld JM Felser JK Dale Acyclovir suppression of frequently recurring genital herpes: efficacy and diminishing need during successive years of treatment JAMA 260 1988 2227 2230
16. GJ Mertz CC Jones J Mills KH Fife SM Lemon JT Stapleton Long-term acyclovir suppression of frequently recurring genital herpes simplex virus infection: a multicenter double-blind trial JAMA 260 1988 201 206
17. HJ Field SE Bell GB Elion AA Nash P. Wildy Effect of acycloguanosine treatment on acute and latent herpes simplex infections in mice Antimicrob Agents Chemother 15 1979 554 561
18. WA Blyth DA Harbour TJ. Hill Effect of acyclovir on recurrence of herpes simplex skin lesions in mice J Gen Virol 48 1980 417 419
19. RJ Klein AE Friedman-Kien E. DeStefano Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine Antimicrob Agents Chemother 15 1979 723 729
20. NH Park D Pavan-Langston SL. McLean Acyclovir in oral and ganglionic herpes simplex virus infections J Infect Dis 140 1979 802 806
21. D Pavan-Langston NH Park JH. Lass Herpetic ganglionic latency aciclovir and vidarabine therapy Arch Ophthalmol 97 1979 1508 1510
22. F Sedarati TP Margolis JG. Stevens Latent infection can be established with drastically restricted transcription and replication of the HSV-1 genome Virology 192 1993 687 691