Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats

Veterinary and Human Toxicology

Volumn 40, Issue 5, 1998, Pages 263-266

  Junnila, Matti ^a,c   Barak, Anthony J ^b   Beckenhauer, Harriet C ^b   Rahko, Timo ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b VA Alcohol Research Center   (United States)

^c NONE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; CARBON TETRACHLORIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG USE; FATTY LIVER; LIPIDOSIS; LIVER METABOLISM; LIVER TOXICITY; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; BETAINE; BODY WEIGHT; CARBON TETRACHLORIDE; COLORING AGENTS; LIPIDOSES; LIPOTROPIC AGENTS; LIVER; LIVER DISEASES; MALE; METHYLATION; RATS; RATS, SPRAGUE-DAWLEY; STAINING AND LABELING; TOLONIUM CHLORIDE; TRIGLYCERIDES;

ANIMALIA;

EID: 0031714308     PISSN: 01456296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Recknagel RO: Carbon tetrachloride hepatotoxicity. Pharmac Rev 19: 145-208, 1967.
2. Meeks RG, Harrison SD, Bull RJ: Hepatotoxicology. CRC Press, Boca Raton, FL: 700, 1991.
3. 4 activation using pulse radiolysis and high energy radiation procedures. FEBS Lett 122: 303-306, 1980.
4. James JL, Friend OS, McDonals JR et al: Alterations in hepatocyte plasma membrane in carbon tetrachloride poisoning. Freeze-fracture analysis of gap junction and electron spin resonance analysis of lipid fluidity. Lab Invest 54: 268-274, 1986.
5. Recknagel RO, Lombardi B, Schotz MC: A new insight into pathogenesis of carbon tetrachloride fat infiltration. Proc Soc Exp Biol Med 104: 608-610, 1960.
6. Constantinides P: Ultrastructural Pathobiology. Elsevier Science Publishers, Amsterdam: 611, 1984.
7. Cheville NF: Ultrastructural Pathology, An Introduction to Interpretation. Iowa State Press, Ames: 946, 1994.
8. Martin R, Wittwer F, Thibaut J et al: Hepatic regenerative drugs in dogs: Effect of choline and silibin in dogs with liver damage. Vet Med Small Ani Clinic 79: 504-510, 1984.
9. Buchman A, Dubin M, Moukarzel A et al: Choline deficiency: A cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. Hepatology 22: 1399-1403, 1995.
10. Sidransky H, Farber E: Liver choline oxidase activity in man and several species of animals. Arc Biochem and Biophysics 87: 129-133, 1960.
11. Best C, Ridout J, Lucas CC: Alleviation of dietary cirrhosis with betaine and other lipotropic agents. Can J Physiol Pharmacol 47: 73-79, 1968.
12. Kloiber O, Banjac B, Drewes LR: Protection against acute hyperammonemia: The role of quaternary amines. Toxicol 49: 83-90, 1988.
13. Barak JA, Beckenhauer HC, Tuma DJ: S-adenosylmethionine generation and prevention of alcoholic fatty liver by betaine. Alcohol 11: 501-503, 1994.
14. Barak AJ, Beckenhauer HC, Junnila M et al: Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration. Alcoh Clin Exp Res 17: 552-555, 1993.
15. Corrales F, Gimenez A, Alvarez L et al: S-adenosylmethionine treatment prevents carbon tetrachlori de-induced S-adenosylmetnionine synthetase inactivation and attenuates liver injury. Hepatology 16: 1022-1027, 1992.
16. Varela-Moreiras G, Alonso-Aperte E, Rubio M et al: Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: Effect cf S-adenosylmethionine treatment. Hepatol 22: 1310-1315, 1995.
17. Lieber CS, Jones DP, DeCarli LM: Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcoholism 24: 197-211, 1989.
18. Committee on Enzymes, Scandinavian Society for Clinical Chemistry and Clinical Pathology: Recommended methods for the determination of four enzymes in blood. Sand J Clin Lab Invest 33: 291-296, 1974,
19. Folch J, Lees M, Stanley G: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509, 1957.
20. Barak AJ, Tuma DJ: A simplified procedure for the determination of betaine in liver. Lipids 14: 860-863, 1979.
21. Eloranta T, Kajander E, Paina A: A new method for the assay of tissue S-adenosylmethionine and S-adenosylhomocysteine. Biochem J 160: 287-294, 1976.
22. Ericson LE, Harper AE: Effect of diet on the betaine-homocysteine transmethylase activity in rat liver. J Biol Chem 219:49-58, 1956.
23. Romeis B: Mikroskopische Technik: Allegmeine Fettfarbemethoden 1046: R Oldenbourg, Munchen, 1948.
24. Luna LG: Manual of Histologie Staining. Methods of the Armed Forces Institute of Pathology, III Ed,. McGraw-Hill, New York: 258, 1968.
25. Bancroft JD, Stevens A, Turner DR: Theory and Practice of Histological Techniques, III Ed. Churchill Livingstone, Edinburgh: 726, 1990.
26. Sherlock S: Alcoholic liver disease. Lancet 345: 227-2291, 1995.
27. Kamimura S, Shoda T, Hiroshi S et al : Hepatic fibrosis in rats fed a liquid diet with ethanol and carbonyl iron. Int Hepatol Comm 3: 70-76, 1995.
28. Teli MR, Day CP, Burt AD et al: Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet 346: 987-990, 1995.
29. Haussinger D: The role of cellular hydration in the regulation of cell function. Review article. Biochem J 313: 697-710, 1996.
30. Zhang F, Warskulat U, Wettstein M et al: Identification of betaine as an osmolyte in rat liver macrophages (Kuppfer cells). Gastroenterology 110: 1543-1552, 1996.
31. Finkelstein JD: Methionine metabolism in mammals: The biological basis for homocystinuria. Metabolism 23: 387-398, 1974.
32. Frontiera MS, Stabler SP, Kolhouse JF et al: Regulation of methionine metabolism: Effects of nitrous oxide and excess dietary methionine. J Nutr Biochem 5: 28-38, 1994.