Active-MMP2 in cancer cell nests of oral cancer patients: Correlation with lymph node metastasis

International Journal of Oncology

Volumn 13, Issue 4, 1998, Pages 699-704

  Kawamata, Hitoshi ^a   Uchida, Daisuke ^a   Hamano, Hironori ^a   Kimura Yanagawa, Tetsuo ^b   Nakashiro, Koh Ichi ^a   Hino, Satoshi ^a   Omotehara, Fumie ^a   Yoshida, Hideo ^a   Sato, Mitsunobu ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b OSAKA POLICE HOSPITAL   (Japan)

Author keywords

Marker; Matrix metalloproteinase (MMP2); Metastasis; Oral cancer

Indexed keywords

GELATINASE A;

ARTICLE; CANCER CELL; CANCER INVASION; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME DEGRADATION; EXTRAVASATION; FIBROBLAST; GINGIVA; HUMAN; HUMAN CELL; LYMPH NODE METASTASIS; MOUTH CANCER; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; STROMA CELL;

EID: 0031712964     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.13.4.699     Document Type: Article

References (23)

1. Kawamata H, Nakashiro K, Uchida D, Harada K, Yoshida H and Sato M: Possible contribution of active MMP2 to lymphnode metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines, Int J Cancer 70: 120-127, 1997.
2. Fidler IJ: Critical factors in the biology of human cancer metastasis; twenty-eighth G. H. A. Clowes Memorial Award lecture. Cancer Res 50: 6130-6138, 1990.
3. Liotta LA and Stetler-Stevenson WG: Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res (Suppl. 51): 5054s-5059s, 1991.
4. Aznavoorian S, Murphy AN, Stetler-Stevenson WG and Liotta LA: Molecular aspects of tumor cell invasion and metastasis. Cancer 71: 1368-1383, 1993.
5. Kawamata H, Kameyama S, Kawai K, Tanaka Y, Nan L, Barch DH, Stetler-Stevenson WG and Oyasu R: Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cell line by the expression of human gelatinase A (72 kDa type collagenase). Int J Cancer 63: 680-687, 1995.
6. Kawamata H, Kawai K, Kameyama S, Johnson MD, Stetler-Stevenson WG and Oyasu R: Overexpression of tissue inhibitor of matrix metalloproteinases (TIMP1 and TIMP2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma. Int J Cancer 63: 568-575, 1995.
7. Poulsom R, Pignatelli M, Stetler-Stevenson WG, Liotta LA, Wright PA, Jeffery RE, Longcroft JM, Rogers L and Stamp GW: Stromal expression of 72 kDa type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorcctal neoplasia. Am J Pathol 141: 389-396, 1992.
8. Pyke C, Ralfkiaer E, Tryggvason K and Dano K: Messenger RNA for two type IV collasenases is located in stromal cells in human colon cancer. Am J Pathol 142: 359-365, 1993.
9. Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E and Seiki M: A matrix metalloproteinase expressed on the surface of invasive tumor cells. Nature 370: 61-65, 1994.
10. Yu M, Sato H, Seiki M and Thompson EW: Complex regulation of membrane-type matrix metalloproteinase expression and matrix metalloprotcinasc-2 activation by concanavalin A in MDA-MB-231 human breast cancer cells. Cancer Res 55: 3272-3277, 1995.
11. Nomura H, Sato H, Seiki M, Mai M and Okada Y: Expression of membrane-type matrix metalloproteinase in human gastric carcinomas. Cancer Res 55: 3263-3266, 1995.
12. Okada A, Bellocq JP, Rouyer N, Chenard MP, Rio MC, Chambon P and Basset P: Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci USA 92: 2730-2734, 1995.
13. Ossowski L: Invasion of connective tissue by human carcinoma cell lines: Requirement for urokinase, urokinase receptor, and interstitial collagcnase. Cancer Res 52: 6754-6760, 1992.
14. Takino T, Sato H, Shinagawa A and Sciki M: Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. J Biol Chem 270: 23013-23020, 1995.
15. Strongin AY, Collier I, Bannikov G, Marmer BL, Grant GA and Goldberg GI: Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease. J Biol Chem 270: 5331-5338, 1995.
16. Monteagudo C, Merino MJ, San-Juan J, Liotta LA and Stetler-Stevenson WG: Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue. Am J Pathol 136: 585-592, 1990.
17. Levy AT, Cioce V, Sobel ME, Garbisa S, Grigioni WF, Liotta LA and Stetler-Stevenson WG: Increased expression of the Mr 72,000 type IV collascnase in human colonie adenocarcinoma. Cancer Res 51: 439-444, 1991.
18. Shima I, Sasaguri Y, Kusukawa J, Yamana H, Fujita H, Kakegawa T and Morimatsu M: Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophaeeal carcinoma. A clinicopathologic study. Cancer 70: 2747-2753, 1992.
19. Kusukawa J, Sasaguri Y, Shima I, Kameyama T and Morimatsu M: Expression of matrix metalloproteinase-2 related to lymph node metastasis of oral squamous cell carcinoma. A clinicopathologic study. Am J Clin Pathol 99: 18-23, 1993.
20. Stearns ME and Wang M: Type IV collagenase (Mr 72,000) expression in human prostate: benicn and malignant tissue. Cancer Res 53: 878-883, 1993.
21. Ueno H, Nakamura H, Inoue M, Imai K, Noguchi M, Sato H, Seiki M and Okada Y: Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas. Cancer Res 57: 2055-2060, 1997.
22. Brown PD, Bloxidge R, Stuart NSA, Gatter C and Carmichael J: Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma. J Natl Cancer Inst 85: 574-578, 1993.
23. Tokukura M, Sato H, Murakami S, Okada Y, Watanabe Y and Seiki M: Activation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-NIMP) and with lymph node metastasis. Int J Cancer 64: 355-359, 1995.