Oxidation of morphine to 2,2'-bimorphine by Cylindrocarpon didymum

Applied and Environmental Microbiology

Volumn 64, Issue 10, 1998, Pages 4106-4108

  Stabler, Peter J ^a   Bruce, Neil C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; MORPHINE DERIVATIVE; PSEUDOMORPHINE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ARTICLE; DRUG OXIDATION; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVITY; FUNGUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

CYLINDROCARPON DIDYMUM; FUNGI;

EID: 0031711918     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/aem.64.10.4106-4108.1998     Document Type: Article

References (9)

1. Bentley, K. W., and S. F. Dyke. 1959. Structure of pseudomorphine. J. Chem. Soc. 81:2574-2577.
2. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
3. Bruce, N. C., C. E. French, A. M. Hailes, M. T. Long, and D. A. Rathbone. 1995. Engineering microbial transformation pathways for the synthesis of morphine alkaloids. Trends Biotechnol. 13:200-205.
4. Dolezalova, M. 1992. Ion-pair high-performance liquid-chromatographic determination of morphine and pseudomorphine in injections. J. Pharm. Biomed. Anal. 10:507-514.
5. Graden, D. W., G. W. Caldwell, F. J. Villani, C. A. Maryanoff, and A. Grant. 1990. H-1 and C-13 NMR-spectra of pseudomorphine and dimethylpseudomorphine. Magn. Reson. Chem. 28:1018-1022.
6. Kupferberg, H. J., A. Burkhalter, and E. L. Way. 1964. Fluorimetric identification of sub-microgram amounts of morphine and related compounds on thin-layer chromatography. J. Chromatogr. 16:558-559.
7. Moffat, A. C., J. V. Jackson, M. S. Moss, and B. Widdop. 1986. Clarke's isolation and identification of drugs. The Pharmaceutical Press, London, United Kingdom.
8. Rahim, M. A., and C. J. Sih. 1966. Mechanisms of steroid oxidation by microorganisms. XI. Enzymic cleavage of the pregnane side chain. J. Biol. Chem. 241:3615-3623.
9. Rosenberger, R. F., and S. R. Elsden. 1960. The yields of Streptococcus faecalis grown in continuous culture. J. Gen. Microbiol. 22:726-739.