Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2

Molecular and Cellular Biology

Volumn 18, Issue 10, 1998, Pages 5921-5929

  Chiorini, John A ^a   Zimmermann, Bastian ^b   Yang, Linda ^a   Smith, Richard H ^a   Ahearn, Aaron ^a   Herberg, Friedrich ^b   Kotin, Robert M ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; VIRUS PROTEIN;

ADENO ASSOCIATED VIRUS; ARTICLE; CELL GROWTH; ENZYME INHIBITION; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS CELL INTERACTION; VIRUS INFECTION; YEAST;

ADENO-ASSOCIATED VIRUS; ADENO-ASSOCIATED VIRUS 2; NEGIBACTERIA;

EID: 0031711520     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.10.5921     Document Type: Article

References (56)

1. Adams, J. A., M. L. McGlone, R. Gibson, and S. S. Taylor. 1995. Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase. Biochemistry 34:2447-2454.
2. Chejanovsky, N., and B. J. Carter. 1989. Replication of a human parvovirus nonsense mutant in mammalian cells containing an inducible amber suppressor. Virology 171:239-247.
3. Chiorini, J. A., M. D. Weitzman, R. A. Owens, E. Urcelay, B. Safer, and R. M. Kotin. 1994. Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli. J. Virol. 68:797-804.
4. Chiorini, J. A., C. M. Wendtner, E. Urcelay, B. Safer, M. Hallek, and R. M. Kotin. 1995. High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors. Hum. Gene Ther. 6:1531-1541,
5. Chiorini, J. A., L. Yang, B. Safer, and R. M. Kotin. 1995. Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection. J. Virol. 69:7334-7338.
6. Cho-Chung, Y. S., S. Pepe, T. Clair, A. Budillou, and M. Nesterova. 1995. cAMP-dependent protein kinase: role in normal and malignant growth. Crit. Rev. Oncol.-Hematol. 21:33-61.
7. Desdouets, C., G. Matisic, C. A. Molina, N. S. Foulkes, P. Sassone-Corsi, C. Brechot, and J. Sohczak-Thepot. 1995. Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factor CREB and CREM. Mol. Cell. Biol. 15:3301-3309.
8. Fantozzi, D. A., A. T. Harootunian, W. Wen, S. S. Taylor, J. R. Feramisco, R. V. Tsien, and J. L. Meinkoth. 1494. Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus. J. Biol. Chem. 269:2676-2686.
9. Fantozzi, D. A., S. S. Taylor, P. W. Howard, R. A. Maurer, J. R. Feramisco, and J. L. Meinkoth. 1992. Effect of the thermostable protein kinase inhibitor on intracellular localization of the catalytic subunit of cAMP-dependent protein kinase. J. Biol. Chem. 267:16824-16834.
10. Faux, M. C., and J. D. Scott. 1996. Molecular glue-kinase anchoring and scaffold proteins. Cell 85:9-12.
11. Guo. B., J. L. Stein, A. J. van Wijnen, and G. S. Stein. 1997. ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element. Biochemistry 36:14447-14455.
12. 11a. Hanks, S. K., and T. Hunter. 1995. Protein kinases. 6. The eukaryotic protein kinases superfamily - kinase (catalytic) domain structure and classification. FASEB J. 9:576-596.
13. Haper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
14. Herberg, F. W., and S. S. Taylor. 1993. Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions. Biochemistry 32:14015-14022.
15. Hermanns, J., A. Schulze, P. Durr, J. A. Kleinschmidt, R. Schmidt, and H. zur Hausen. 1997. Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins. J. Virol. 71:6020-6027.
16. Hermonat, P. L. 1989. The adeno-associated virus Rep78 gene inhibits cellular transformation induced by bovine papillomavirus. Virology 172:253-261.
17. Hermonat, P. L. 1991. Inhibition of H-ras expression by the adeno-associated virus Rep78 transformation suppressor gene product. Cancer Res. 51:3373-3377.
18. Hermonat, P. L. 1992. Inhibition of bovine papillomavirus plasmid DNA replication by adeno-associated virus. Virology 189:329-333.
19. Hong, G., P. Ward, and K. I. Berns. 1992. In vitro replication of adenoassociated virus DNA. Proc. Natl. Acad. Sci. USA 89:4673-4677.
20. Hörer, M., S. Weger, K. Butz, F. Hoppe-Seyler, C. Geisen, and J. A. Kleinschmidt. 1995. Mutational analysis of adcno-associatcd virus rep protein-mediated inhibition of heterologous and homologous promoters. J. Virol. 69:5485-5496.
21. Huang, D., P. M. Shipman-Appasamy, D. J. Orten, S. H. Hinrichs, and M. B. Prystowsky. 1994. Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes. Mol. Cell. Biol. 14:4233-4243.
22. Hunter, L. A., and R. J. Samulski. 1992. Colocalization of adeno-associated virus Rep and capsid proteins in the nuclei of infected cells. J. Virol. 66:317-324.
23. Im, D.-S., and N. Muzyczka. 1990. The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity. Cell 61:447-457.
24. Kerlavage, A. R., and S. S. Taylor. 1980. Covalent modification of an adenosine 3′:5′-monophosphate binding site of the regulatory subunit of cAMP-dependent protein kinase II with 8-azidoadenosine 3′:5′-monophosphate. Identification of a single modified tyrosine residue. J. Biol. Chem. 255:8483-8488.
25. Khleif, S. N., T. Myers, B. J. Carter, and J. P. Trempe. 1991. Inhibition of cellular transformation by the adeno-associated virus rep gene. Virology 181:738-741.
26. Klink, A., K. Schiebet, M. Winkelmann, E. Rao, B. Horsthemke, H.-J. Lüdecke, U. Claussen, G. Scherer, and G. Rappold. 1995. The human protein kinase gene PKX1 on Xp22.3 displays Xp/Xp homology and is a site of chromosomal instability. Hum. Mol. Genet. 4:869-878.
27. Knighton, D. R., J. Zheng, L. F. Ten Eyck, V. A. Ashford, N.-H. Xuong, S. S. Taylor, and J. M. Sowadski. 1991. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253:407-413.
28. Kotin, R. M., R. M. Linden, and K. I. Berns. 1992. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. EMBO J. 11:5071-5078.
29. Kotin, R. M., J. C. Menninger, D. C. Ward, and K. I. Berns. 1991. Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Genomics 10:831-834.
30. Kotin, R. M., M. Siniscalco, R. J. Samulski, X. Zhu, L. Hunter, C. A. Laughlin, S. McLaughlin, N. Muzyczka, M. Rocchi, and K. I. Berns. 1990. Site-specific integration by adeno-associated virus. Proc. Natl. Acad. Sci. USA 87:2211-2215.
31. Labow, M. A., and K. I. Berns. 1988. The adeno-associated virus rep gene inhibits replication of an adeno-associated virus/simian virus 40 hybrid genome in cos-7 cells. J. Virol. 62:1705-1712.
32. Labow, M. A., L. H. Graf, Jr., and K. I. Berns. 1987. Adeno-associated virus gene expression inhibits cellular transformation by heterologous genes. Mol. Cell. Biol. 7:1320-1325.
33. Lamb, N. J., J. C. Cavadore, J. C. Labbe, R. A. Maurer, and A. Fernandez. 1991. Inhibition of cAMP-dependent protein kinase plays a key role in the induction of mitosis and nuclear envelope breakdown in mammalian cells. EMBO J. 10:1523-1533.
34. Meléndez, A., W. Li, and D. Kalderon. 1995. Activity, expression and function of a second Drosophila protein kinase A catalytic subunit gene. Genetics 141:1507-1520.
35. Meyer, T. E., G. Waeber, J. Lin, W. Beckmann, and J. F. Habener. 1993. The promoter of the gene encoding 3′,5′-cyclic adenosine monophosphate (cAMP) response elements binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription. Endocrinology 132:770-780.
36. Montminy, M. 1997. Transcriptional regulation by cyclic AMP. Annu. Rev. Biochem. 66:807-822.
37. Ni, T.-H., X. Zhou, D. M. McCarty, I. Zolotukhin, and N. Muzyczka. 1994. In vitro replication of adeno-associated virus DNA. J. Virol. 68:1128-1138.
38. Patwardhan, S., A. Cashler, M. G. Siegel, L. C. Chang, L. J. Joseph, T. B. Shows, M. M. Le Beau, and V. P. Sukhatme. 1991. EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene 6:917-928.
39. Smith, R. A., J. A. Chiorini, and R. M. Kotin. Unpublished observations.
40. Smith, R. H., and R. M. Kotin. 1998. The Rep52 gene product of adenoassociated virus is a DNA helicase with 3′-to-5′ polarity. J. Virol. 72:4874-4881.
41. Smith, R. H., and R. M. Kotin. 1998. The Rep52 gene product of adenoassociated virus is a DNA helicase with 3′-to-5′ polarity. J. Virol. 72:4874-4881.
42. Snyder, R. O., D.-S. Im, T. Ni, X. Xiao, R. J. Samulski, and N. Muzyczka. 1993. Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein. J. Virol. 67:6096-6104.
43. Snyder, R. O., D. S. Im, and N. Muzyczka. 1990. Evidence for covalent attachment of the adeno-associated virus (AAV) rep protein to the ends of the AAV genome. J. Virol. 64:6204-6213.
44. Taylor, S. S., E. Radzioandzelm, and T. Hunter. 1995. Protein kinases. How do protein kinases discriminate between serine threonine and typrosine- structural insights from the insulin receptor protein-tyrosine kinase? FASEB J. 9:1255-1266.
45. 43a. Taylor, S. S., and E. Radzio-Andzelm. 1994. Cyclic AMP-dependent protein kinase. In J. R. Woodgett (ed.), Protein kinases. Oxford University Press, Oxford, United Kingdom.
46. Urcelay, E., P. Ward, S. M. Wiener, B. Safer, and R. M. Kotin. 1995. Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein. J. Virol. 69:2038-2046.
47. Walsh, D. A., C. D. Ashby, C. Gonzalez, D. Calkins, E. H. Fischer, and E. G. Kerbs. 1971. Purification and characterization of a protein inhibitor ofadenosine 3′,5′-monophosphate-dependent protein kinases. J. Biol. Chem. 246:1977-1987.
48. Ward, P., and K. I. Berns. 1991. In vitro rescue of an integrated hyhrid adeno-associated virus/simian virus 40 genome. J. Mol. Biol. 218:791-804.
49. Webster, L. C., and R. P. Ricciardi. 1991. Trans-dominant mutants of E1a provide genetic evidence that the inc finger of the trans-activating domain binds a transcription factor. Mol. Cell. Biol. 11:4287-4296.
50. Weitzman, M. D., S. R. M. Kyöstiö, R. M. Kotin, and R. A. Owens. 1994. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA. Proc. Natl. Acad. Sci. USA 91:5808-5812.
51. Wen, W., S. S. Taylor, and J. L. Meinkoth. 1995. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated. J. Biol. Chem. 270:2041-2046.
52. Wonderling, R. S., S. R. M. Kyostio, and R. A. Owens. 1995. A maltosebinding protein/adeno-associated virus rep68 fusion protein has DNA-RNA helicase and ATPase activities. J. Virol. 69:3542-3548.
53. Wonderling, R. S., S. R. M. Kyostio, S. L. Walker, and R. A. Owens. 1997. The rep68 protein of adeno-associated virus type 2 increases RNA levels from the human cytomegalovirus major immediate early promoter. Virology 236:167-176.
54. Yang, Q., F. Chen, and J. P. Trempe. 1994. Characterization of cell lines that inducibly express the adeno-associated virus Rep proteins. J. Virol. 68:4847-4856.
55. Yoshizumi, M., H. Wang, C. M. Hsieh, N. E. Sibinga, M. A. Perrella, and M. E. Lee. 1997. Down-regulation of the cyclin A promoter by transforming growth factor-beta 1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein. J. Biol. Chem. 272:22259-22264.
56. Zimmermann, B., J. A. Chiorini, R. M. Kotin, and F. Herberg. Unpublished data.