Protection of the allylic alcohol double bond from catalytic reduction in the preparation of [1-3H]morphine and [1-3H]codeine

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 41, Issue 9, 1998, Pages 811-821

  Seltzman, Herbert H ^a   Roche, Michael J ^a   Laudeman, Christopher P ^a   Wyrick, Christopher D ^a   Carroll, F Ivy ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

Allyl silyl ether; Catalytic tritiation; Codeine; Morphine; Olefin protection; Selectivity

Indexed keywords

ALLYL SILYL ETHER; ALLYLIC ALCOHOL; CATALYTIC TRITIATION; CODEINE; DOUBLE BONDS; MORPHINE; OLEFIN PROTECTION; SELECTIVITY; SILYL ETHERS; TRITIATION;

REDUCTION;

ALKENE; ALLYL ALCOHOL; CODEINE; MORPHINE; TRITIUM;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; DRUG LABELING; DRUG SYNTHESIS; ISOTOPE LABELING; SIALYLATION;

TRITIUM;

EID: 0031711413     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(1998090)41:9<811::AID-JLCR132>3.0.CO;2-3     Document Type: Article

References (4)

1. Bloxsidge J.P., Elvidge J.A., Gower M., Jones J.R., Evans E.A., Kitcher J.P. and Warrell D.C. - J. Labelled Compd. Radiopharm. XVIII: 1141 (1981).
2. A. H. Lewin and P. Lamb - Unreported results from these laboratories,
3. Liebman A.A., Malarek D.H., Blount J.F., Nelson N.R. and Delaney C.M. - J. Org. Chem. 43(4): 737 (1978).
4. Neville G.A., Ekiel I. and Smith I.C.P. - Magn. Reson. Chem., 25(1): 31 (1987).