Roles of Na-K-2Cl and Na-Cl cotransporters and ROMK potassium channels in urinary concentrating mechanism

American Journal of Physiology - Renal Physiology

Volumn 275, Issue 3 44-3, 1998, Pages

  Hebert, Steven G ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bartter's syndrome; Distal convoluted tubule; Thick ascending limb of Henle

Indexed keywords

CARRIER PROTEIN; CHLORIDE ION; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM CHLORIDE; SODIUM ION;

APICAL MEMBRANE; BARTTER SYNDROME; HENLE LOOP; HUMAN; ION TRANSPORT; KIDNEY CONCENTRATING CAPACITY; KIDNEY DISTAL TUBULE; KIDNEY TUBULE ABSORPTION; MOLECULAR CLONING; PRIORITY JOURNAL; REVIEW;

EID: 0031711390     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1998.275.3.f325     Document Type: Review

References (20)

1. + channel. II. Cloning and intra-renal distribution of alternatively spliced forms. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol 37): F1132-F1140, 1995.
2. Gamba, G., A. Miyanoshita, M. Lombardi, J. Lytton, W.-S. Lee, M. A. Hediger, and S. C. Hebert. Molecular cloning, primary structure and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J. Biol. Chem. 269: 17713-17722, 1994.
3. Gamba, G., S. N. Saltzberg, M., Lombardi, A. Miyanoshita, J. Lytton, M. A. Hediger, B. M. Brenner, and S. C. Hebert. Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter. Proc. Natl. Acad. Sci. USA 90: 2749-2753, 1993.
4. Greger, R. Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron. Physiol. Rev. 65: 760-797, 1985.
5. Greger, R., and H. Velazquez. The cortical thick ascending limb and early distal convoluted tubule in the urinary concentrating mechanism. Kidney Int. 31: 590-596, 1987.
6. Hebert, S. C., and T. E. Andreoli. Control of NaCl transport in the thick ascending limb. Am. J. Physiol. 246 (Renal Fluid Electrolyte Physiol. 15): F745-F756, 1984.
7. - absorption J. Gen Physiol. 87: 567-590, 1986.
8. Ho, K., C. G. Nichols, W. J. Lederer, J. Lytton, P. M. Vassilev, M. V. Kanazirska, and S. C. Hebert. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 362: 31-38, 1993.
9. Kaplan, M. R., M. D. Plotkin, W.-S. Lee, Z.-C. Xu, J. Lytton, and S. C. Hebert. Apical localization of the Na-K-Cl cotransporter, rBSC1, on rat thick ascending limbs. Kidney Int. 49: 40-47, 1996.
10. Karolyil, L., M. Konrad, A. Kockerling, A. Ziegler, D. K. Zimmerman, B. Roth, C. Wieg, K.-H. Grzeschik, M. C. Koch, H. W. Seyberth, R. Vargus, L. Forestier, G. Jean, M. Deschaux, G. F. Rizzoni, P. Niaudet, C. Antignac, D. Feldman, F. Lorridon, E. Cougoureux, F. Laroze, J.-L. Alessandri, L. David, P. Saunier, G. Deschenes, F. Hildebrandt, M. Vollmer, W. Proesmans, M. Brandis, L. P. W. J. van den Heuvell, H. H. Lemmink, W. Nillesen, L. A. H. Monnens, N. V. A. M. Knoers, L. M. Guay-Woodford, C. J. Wright, G. Madrigal, and S. C. Hebert. Mutations in the gene encoding the inwardly-rectifying renal potassium channel, ROMK, cause the antenatal variant of Bartter syndrome: evidence for genetic heterogeneity. Hum. Mol. Genet. 6: 17-26, 1997.
11. + channel. I. Expression in rat distal nephron segments. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F1124-F1131, 1995.
12. Lemmink, H. H., L. P. W. J. van den Heuvell, H. A. van Dijk, G. F. M. Merkx, T. J. Smilde, P. E. M. Taschner, L. A. H. Monnens, S. C. Hebert, and N. V. A. M. Knoers. Linkage of Gitelman syndrome to the human thiazide-sensitive sodium-chloride cotransporter gene with identification of mutations in three Dutch families. Pediatr. Nephrol. 10: 403-407, 1996.
13. Payne, J. A., and B. Forbush III. Alternatively spliced isoforms of the putative renal Na-K-Cl cotransporter are differentially distributed within the rabbit kidney. Proc. Natl. Acad. Sci. USA 91: 4544-4548, 1994.
14. Plotkin, M. D., M. R. Kaplan, J. W. Verlander, W.-S. Lee, D. Brown, E. Poch, S. R. Gullans, and S. C. Hebert. Localization of the thiazide sensitive Na-Cl cotransporter, rTSC1, in the rat kidney. Kidney Int. 50: 174-183, 1996.
15. Pollak, M. R., V. B. Delaney, R. M. Graham, and S. C. Hebert. Gitelman's syndrome (Bartter's variant) maps to the thiazide-sensitive cotransporter gene locus on chromosome 16q13 in a large kindred. J. Am. Soc. Nephrol. 7: 2244-2248, 1996.
16. Shuck, M. E., J. H. Block, C. W. Benjamin, T.-D. Tsai, K. S. Lee, J. L. Slightom, and M. J. Bienkowski. Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel. J. Biol. Chem. 269: 24261-24270, 1994.
17. Simon, D. B., F. E. Karet, J. M. Hamdan, A. DiPietro, S. A. Sanjad, and R. P. Lifton. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat. Genet. 13: 183-188, 1996.
18. + channel, ROMK. Nat. Genet. 14: 152-156, 1996.
19. Simon, D. B., C. Nelson-Williams, M. J. Bia, D. Ellison, F. E. Karet, A. M. Molina, I. Vaara, F. Iwata, H. M. Cushner, M. Koolen, F. J. Gainza, H. J. Gitelman, and R. P. Lifton. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat. Genet. 12: 24-30, 1996.
20. Zhou, H., S. S. Tate, and L. G. Palmer. Primary structure and functional properties of an epithelial K channel. Am. J. Physiol. 266 (Cell Physiol. 35): C809-C824, 1994.