Mitogenic short-term effects on hepatocytes and adrenocortical cells: Phenobarbital and reserpine compared to carcinogenic and non-carcinogenic fluorene derivatives

Experimental and Toxicologic Pathology

Volumn 50, Issue 4-6, 1998, Pages 416-424

  Danz, M ^a,d   Hartmann, A ^b   Blaszyk, H ^c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c MAYO CLINIC   (United States)

^d JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Adrenal cortex; Carcinogens; Dose dependency; Fluorene derivatives; Hepatocytes; Phenobarbital; Primary mitogenicity; Reserpine; Structure activity relationship

Indexed keywords

CARCINOGEN; CORTICOTROPIN; FLUORENE DERIVATIVE; FLUORENONE DERIVATIVE; N (2 FLUORENYL)ACETAMIDE; PHENOBARBITAL; RESERPINE; XENOBIOTIC AGENT;

ADRENAL CORTEX CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL DIVISION; CELL RENEWAL; CONTROLLED STUDY; GENOTOXICITY; LIVER CELL; MALE; NONHUMAN; RAT; STRESS; WEIGHT REDUCTION; ZONA FASCICULATA; ZONA GLOMERULOSA;

EID: 0031711354     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(98)80028-6     Document Type: Article

References (71)

1. AMES BN, McCANN J, YAMASAKI E: Methods for detecting carcinogens and mutagens with the Salmonella/ mammalian-microsome mutagenicity test. Mutât Res 1975; 31:346-364.
2. ARCOS JG, ARGUS MF: Chemical Induction of Cancer, Vol. IIB. Academic Press New York 1974: pp 41-62.
3. ASHBY J, LEFEVRE PA, BURLINSON B, BEIJE B: Potent mitogenic activity of 4-acetylaminofluorene to rat liver. Mutât Res 1986; 172: 271-279.
4. ASHBY J, TENNANT RW: Definitive relationship among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutât Res 1991; 257: 229-306.
5. AYRTON AD, MCFARLANE M, WALKER R et al.: The induction of P4501 proteins by aromatic amines may be related to their carcinogenic potential. Carcinogenesis 1990; 11: 803-809.
6. BEIJE B, MÖLLER L: 2-Nitrofluorene and related compounds: prevalence and biological effects. Mutât Res 1988; 196: 177-209.
7. BENGTSSON M, HALLBERG E, GEORGELLIS A, RYDSTROM J: On the identity of the xenobiotic-metabolizing form(s)
8. of cytochrome P-450 in endocrine organs. Cancer Lett 1990;52:235-241.
9. BOMHARD E: Frequency of spontaneous tumors in Wistar rats in 30-months studies. Exp Toxic Pathol 1992: 44:381-392.
10. BUTTERWORTH BE, CoNOLLY RB, MORGAN KT: A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments. Cancer Lett 1995; 93: 129-146.
11. DALLMAN MF, ENGELAND WC, et al.: Nycthemeral rhythm in adrenal responsiveness to ACTH. Am J Physiol 1978; 235: R210-R218.
12. DALLMAN MF: Control of adrenocortical growth in vivo. Endocr. Res. 1984-85; 10: 213-242.
13. DALLMAN MF, AKANA SF, SCRIBNER KA, et al.: Stress, feedback and facilitation in the hypothalamopituitary-adrenal axis. J Neuroendocrinol 1992; 4: 517-526.
14. DANZ M, BOLCK F: Stimulation of adrenal cell proliferatioin in normal rats by carcinogen- induced serum factors. Exp Path 1980; 18: 414-422.
15. DANZ M, HARTMANN A, OTTO M, BLASZYK H: Hitherto unknown additive growth effects of fluorene and 2-acetylaminofluorene on bile duct epithelium and hepatocytes in rats. Arch Toxicol 1991, Suppl. 14: 71-75.
16. DANZ M, MüLLER D, RäTHE H: Fluorenone and 2-benzoylfluorenone: different short-term effects on drug-metabolizing liver enzymes and on cell proliferation. Exp Toxic Path 1992; 44: 259-261.
17. DANZ M, SÄNGER J, FRIEDRICHSEN K, LINSS W: 2-Acetylaminofluorene-produced selective cytotoxic damage of a ductal compartment and its repair in the submandibular gland of rats. Cell Tissue Res 1997; 288: 371-379.
18. DANZ M, URBAN H, SCHMIDT A: Prevention of 2-acetylaminofluorene-induced extrahepatic short-term effects by 3-methylcholanthrene. Exp Path 1977; 13: 262-267.
19. DANZM, URBAN H, KLUPSCH R: The modification of rat liver regeneration by carcinogens and its reflection by extrahepatic tissues. Exp Path 1980; 18: 57-74.
20. DANZ M, URBAN H: Elevated mitotic number in the adrenal cortex as a reflection of early events in growth induction by carcinogens and promoters - a possible short-term assay. Arch Toxicol 1980, Suppl. 4: 19-21.
21. ENSLEIN K, LANDER TR, TOMB ME, et al.: A predictive model for estimating rat oral LD50 values. Princeton Scientific Publishers, Inc, Princeton 1983.
22. ERHART-BORNSTEIN M, BORNSTEIN SR, GONZALEZ-HERNANDEZ J, et al.: Sympathoadrenal regulation of adrenocortical steroidogenesis. Endocrine Res. 1995; 21:13-24.
23. FABRAZZO M, COSTA E, MOCCHETTI I: Stimulation of nerve growth factor biosynthesis in developing rat brain by reserpine: steroid as potential mediators. Mol Pharmacol 1991; 39: 144-149.
24. FARBER E: The pathology of experimental liver cell cancer. In: Cameron HM, Linsell DA,\Varwick GP (eds.), Liver Cell Cancer, 1976, Elsevier Science Publishers B.V., Amsterdam; pp 243-277.
25. FEIGE JJ, BAIRD A: Growth factor regulation of adrenal cortex growth and function. Progr Growth Factor Res 1991; 3: 103-113.
26. GAILLET S, LACHUER J, MALAVAL F, et al.: The involvement of adrenergic ascending pathways in the stressinduced activation of ACTH and corticosterone secretions is dependent on the nature of Stressors. Exp Brain Res 1991; 87: 173-180.
27. GOLD LS, SLONE TH, STERN BR, BERSTEIN L: Comparison of target organs of carcinogenicity for mutagenic and non-mutagenic chemicals. Mutât Res - Fund Molec Mechan Mutagen 1993; 286: 75-100.
28. GOLDSTEIN BD: Risk assessment methodology: maximum tolerated dose and two-stage carcinogenesis models. Toxicol Pathol 1994:22: 194-197.
29. GOSPODAROWICZ D: Biological activity in vivo and in vitro of pituitary and brain fibroblast growth factor. In: Mediators in Cell Growth and Differentiation. FORD RJ and MAIZEL AL (eds.); Raven Press, New York 1985, pp. 109-134.
30. GüNTHER G, HüBNER K, SCHNEIDER E: Die quantitative Bedeutung der Mitosen bei kompensatorischem Wachstum der Leber und der Nebennierenrinde. Beitr Path Anat 1969; 139: 261-274.
31. HOLZWARTH MA, GOMEZ-SANCHEZ CE, ENGELAND WC: Phenotype of proliferating cells stimulated during compensatory adrenal growth. Endocrine Res 1996; 22: 401-406.
32. HUFF JE, CIRVELLO J, HASEMAN J, BUCHER J: Chemicals associated with site-specific neoplasia in 1394 longterm carcinogenesis experiments in laboratory rodents. Environm Hlth Perspect 1991; 93: 247-270.
33. HUFF JE, EUSTIS SL, HASEMAN JK: Occurence and relevance of chemically induced benign neoplasms in longterm carcinogenicity studies. Cancer Metast Rev 1989; 8: 1-21.
34. ITO N, IMAIDA K, HASEGAWA R, TSUDA H: Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis. CRC Crit. Rev. Toxicol. 1989; 19: 385-415.
35. JAHN F, PLANZ N, DANZ M, MüLLER D: Influence of 2acetylaminofluorene (2-AAF) on biotransformation and lipid peroxidation in salivary glands and liver from male rats. Exp Toxic Pathol 1998; 50: 465-471.
36. KIRILLOV OI: Cell mechanisms of stress (russ.). Far East Publishing House, Vladivostok 1973.
37. KLOPMAN G, FRIERSON MR, ROSENKRANZ HS: The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: the gene-tox data base. Mutât Res 1990; 228: 1-50.
38. LABORIT H: The major mechanisms of stress. In: Methods and Achievements in Exp Pathol; G JASMIN, L PROSCHEK (eds), Basel, Karger, 1991; 15: 1-26.
39. LA VOIE EJ, TULLEY L, BEDENKO V, HOFFMANN D: Mutagenicity of methylated fluorenes and benzofluorenes. Mutât Res 1981; 91: 167-176.
40. LEFFERT HL, KOCH KS, MORAN T, RUBALCAVA B: Hormonal control of rat liver regeneration. Gastroenterology 1979; 76: 1470-1482.
41. LINDROOS P, TSAI WH, ZARNEGAR R, MICHALOPOULOS GK: Plasma levels of HGF in rats treated with tumor promoters. Carcinogenesis 1992; 13: 139-141.
42. LINDROOS P, ZARNEGAR R, MICHALOPOULOS GK: Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration. Hepatology 1991; 13: 743-750.
43. LOURY DJ, GOLDSWORTHY TL, BUTTERWORTH BE: The value of measuring cell replication as a predictive index of tissue-specific tumorigenic potential. In: Nongenotoxic Mechanisms in Carcinogenesis. Banbury Report 1987; 25: 119-136.
44. MAICKEL RP, WESTERMANN EO, BRODIE BB: Effects of reserpine and cold-exposure on pituitary- adrenocortical function in rats. J Pharmacol Exp Ther 1961; 134: 167-172.
45. MALEJKA-GIGANTI D, MAGAT WJ, DECKER RW: Sex hormone-mediated effects on the phase I and phase II metabolism of N-2-fluorenylacetamide. Modulation of 9-hydroxylation. Biochem Pharmacol 1989; 38: 1075-1082.
46. MATSUDA T, IMAOKA S, FUNAE Y, et al.: Induction of CYP isoenzymes in various organs of rats by 3-methylcholanthrene or -naphthoflavone. Cancer Lett 1995; 97: 137-143.
47. MATSUMOTO K, NAKAMURA T: Roles of HGF as a pleiotropic factor in organ regeneration. In: Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and c-met Receptor. Goldberg ID and Rosen EM (eds.); Birkhauser Verl. Basel, 1993; Experientia Suppl. 65: 225-250.
48. McNicoL AM, PENMAN ID, DUFFY AE: Age-related variation in circadian rhythms of mitosis in the adrenal cortex of the male rat. J Endocrinol 1989; 120: 307-310.
49. MICHALOPOULOS GK, ZARNEGAR R: Hepatocyte growth factor. Hepatology 1992; 15: 149-155.
50. MILLER EC, MILLER JA, BROWN RR, MACüONALD JC: On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene. Cancer Res. 1958; 18: 469-477.
51. MITANI F, OGISHIMA T, MIYAMOTO H, ISHIMURA Y: Localization of P450aldo and P4501 I in normal and regenerating rat adrenal cortex. Endocrine Res 1995; 21: 413-423.
52. MORRIS HP, WAGNER BP, RAY FE, et al.: Comparative study of cancer and other lesions of rats fed N,N'-2,7fluorenylbisacetamide. Natl Cancer Inst Monogr 1961; 5: 1-53.
53. NEGRIE C, NALTCHAYAN S, BOUHNIK J, MICHEL R: Comparative effects of dexamethasone and phénobarbital on adrenal cortex, liver cytochrome P450 contents and serum thyroid hormones. J Steroid Biochem 1979; 10: 431-435.
54. PERAINO C, FRY RJM, STAFFELDT E, CHRISTOPHER JP: Comparative enhancing effects of phénobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichlorethane on 2-acetylaminofluorene-induced tumorigenesis in the rat. Cancer Res 1975; 35: 2884-2890.
55. RAMEL C: Deployment of short-term assays for the detection of carcinogens; genetic and molecular considerations. Mutât Res 1986; 168: 327-342.
56. RINAUDO JAS, ERIKSSON LC, ROOMI MW, FARBER E: Kinetics of excretion of 2-acetylaminofluorene in normal and xenobiotic-treated rats and in rats with hepatocyte nodules. Lab. Invest. 1989; 60: 399-408.
57. RiviER C: Involvement of endogenous corticotropin-releasing factor (CRF) in modulating ACTH and LH secretion function during exposure to stress, alcohol or cocaine in the rat. Molecular Biology of Stress. Alan R. Liss, Inc 1989,31-47.
58. RIVIER C: Influence of immune signals on the hypothalamic-pituitary axis of the rodent. Frontiers in Neuroendocrinol 1995; 16: 151-182,
59. SCHULTE-HERMANN R, SCHUPPLER J, OHDE G, TlMMER
60. MANN-TROSIENER I: Effect of tumor promoters on proliferation of putative preneoplastic cells in rat liver. In: Carcinogenesis, Vol. 7, Hecker E et al. (eds.), Raven Press, New York; pp 99-104.
61. SELYE H: The evolution of the stress concept. Amer. Sei. 1973; 61: 692-699.
62. SHIRAI T, IMAIDA K, OHSHIMA M, et al.: Different responses to phénobarbital promotion in the development of y-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2acetylaminofluorene and aflatoxin B1. Jpn J Cancer Res (Gann) 1985; 76: 16-19.
63. SHIRAI T: A medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential: a historical review of model development and summary of results from 291 tests. Toxicol Pathol 1997; 25: 453-460.
64. SOLT DB, MEDLINE A, FARBER: Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for sequential analysis of liver carcinogenesis. Am J Pathol 1977; 88: 595-618.
65. STACHOWIAK A, NUSSDORFER GG, MALENDOWICZ LK: Proliferation and distribution of adrenocortical cells in the gland of ACTH- or dexamethasone-treated rats. Histol Histopathol 1990; 5: 25-29.
66. TILSON HA, KAVLOCK RJ: The workshop on endocrine disrupter research needs: a report. Neurotoxicology 1997; 18: 389-392.
67. TISCHLER AS, RUZICKA LA, DONAHUE SR, DELELLIS RA: Chromaffin cell proliferation in the adult rat adrenal medulla. Int J Dev Neurosci 1989; 7: 439-448.
68. VAINIO H, HESELTINE E, McGREGOR D, et al.: Meeting Report; Working Group on Mechanisms of Carcinogenesis and the Evaluation of Carcinogenic Risks. Cancer Res 1992; 52: 2357-2361.
69. WEISBURGER JH, WILLIAMS GM: Types and amounts of carcinogens as potential human cancer hazards. Cell Biol Toxicol 1989; 5: 377-391.
70. WESSEL TC, JOH TH: Parallel upregulation of catecholamine-synthesizing enzymes in rat brain and adrenal gland: effects of reserpine and correlation with immediate early gene expression. Molec Brain Res 1992; 15: 349-360.
71. WILLIAMS GM: Epigenetic mechanisms of liver tumor promotion. In: Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons. Alan R. Liss, Inc., 1990, 131-145.