Biochemical assay for AD7C-NTP in urine as an Alzheimer's disease marker

Journal of Clinical Laboratory Analysis

Volumn 12, Issue 5, 1998, Pages 285-288

  Ghanbari, Hossein ^a   Ghanbari, Kasra ^a   Beheshti, Iraj ^a   Munzar, Michael ^a   Vasauskas, Audrey ^a   Averback, Paul ^a  

^a Nymox Corporation   (United States)

Author keywords

Alzheimer's diagnostic test; Alzheimer's marker; NTP; Urinary AD7C test

Indexed keywords

BIOCHEMICAL MARKER; MONOCLONAL ANTIBODY; NERVE PROTEIN; NEURAL THREAD PROTEIN; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; NEUROLOGIC DISEASE; PROTEIN CONTENT; URINALYSIS;

ALZHEIMER DISEASE; ANTIBODIES, MONOCLONAL; BIOLOGICAL MARKERS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; NERVE TISSUE PROTEINS;

EID: 0031711064     PISSN: 08878013     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2825(1998)12:5<285::AID-JCLA6>3.0.CO;2-5     Document Type: Article

References (16)

1. Khachaturian ZS: Diagnosis of Alzheimer's disease. Arch Neurol 42:1097-1105, 1985.
2. McKhann G, Drachman D, Folstein M, et al.: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944, 1984.
3. Roses AD: Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease. Ann Neurol 38:614, 1995.
4. Arai H, Terajima M, Higuchi S, et al.: Tau in cerebrospinal fluid: A potential diagnostic marker in Alzheimer's disease. Ann Neurol 38:649-652, 1995.
5. Jensen M, Basun H, Lannfelt L: Increased cerebrospinal fluid tau in patients with Alzheimer's disease. Neurosci Lett 186:189-191, 1995.
6. Tato RE, Frank A, Hernanz A: Tau protein concentrations in cerebrospinal fluid of patients with dementia of the Alzheimer type. J Neurol Neurosurg Psychiatry 45:778-793, 1995.
7. Vigo-Pelfrey C, Seubert P, Barbour R, et al.: Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease. Neurology 45:778-793, 1995.
8. Motter R, Vigo-Pelfrey C, Kholodenko D, et al.: Reduction of β-amyloid peptide 42 in the cerebrospinal fluid of the patients with Alzheimer's disease. Ann Neurol 38:643-648, 1995.
9. More H, Hosoda K, Matsubara E, et al. Tau in cerebrospinal fluids: establishment of sandwich ELISA with antibody specific to the repeat sequence in tau. Neurosci Lett 186:181-183, 1995.
10. Munroe WA, Southwick PC, Chang L, et al.: Tau protein in cerebrospinal fluid as an aid in the diagnosis of Alzheimer's disease. Ann Clin Lab Sci 25:207-217, 1995.
11. Pirttila T, Kim KS, Mehta PD, et al.: Soluble amyloid-β-protein in the cerebrospinal fluid of patients with Alzheimer's disease, vascular dementia and controls. J Neurol Sci 127:90-95, 1994.
12. de la Monte SM, Wands JR: Neuronal thread protein over-expression in brains with Alzheimer's disease lesions. J Neurol Sci 113:152-164, 1992.
13. de la Monte SM, Carlson RI, Brown NV, et al.: Profiles of neuronal thread protein expression in Alzheimer's disease. J Neuropathol Exp Neurol 55:1038-1050, 1996.
14. de la Monte SM, Ghanbari K, Frey WH, et al.: Characterization of the AD7C-NTP cDNA expression in Alzheimer's disease and measurement of a 41-kD protein in cerebrospinal fluid. J Clin Invest 100:3093-3104, 1997.
15. Ghanbari K, and Ghanbari HA: A sandwich enzyme immunoassay for measuring AD7C-NTP as an Alzheimer's disease marker: AD7C test. J Clin Lab Anal 12:223-226, 1998.
16. Ghanbari HA, Gharbari K, Munzar M, and Averback P.: Specificity of AD7C-NTP as a biochemical marker for Alzheimer's disease. J Contemp Neurol 1998(4) 2-6, 1998.