Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression

European Journal of Pharmacology

Volumn 354, Issue 1, 1998, Pages 99-104

  Blaya, Carolina ^a   Crespo, Jaime ^a   Crespo, Antonio ^a   Aliño, Salvador F ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Cyclooxygenase inhibition; Cytotoxicity; H 7; H 8; Indomethacin; Lewis lung carcinoma; Metastasis; Protein kinase inhibition

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; INDOMETACIN; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; INTRAVENOUS DRUG ADMINISTRATION; LUNG CARCINOMA; LUNG METASTASIS; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; CARCINOMA, LEWIS LUNG; CELL DIVISION; CYCLOOXYGENASE INHIBITORS; CYTOTOXICITY, IMMUNOLOGIC; DISEASE PROGRESSION; ENZYME INHIBITORS; INDOMETHACIN; ISOQUINOLINES; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; SPLEEN;

EID: 0031710172     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00434-8     Document Type: Article

References (27)

1. Alexandrov, V.A., Bespolov, V.G., Petrov, A.S., Troyan, D.N., Lidaks, M., Yu, 1996. Study of post-natal effect of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats: III. Inhibitory action of indomethacin, voltaren, theophylline and epsilon-aminocaproic acid. Carcinogenesis 17, 1935-1939.
2. Aliño, S.F., Unda, F.J., Pérez-Yarza, G., Cañavate, M.L., 1989. Are laminin binding sites on tumor cell surface involved in the indomethacin-induced sensitivity to natural cytotoxic cells?. Biol. Cell 66, 255-261.
3. Aliño, S.F., Unda, F.J., Pérez-Yarza, G., 1990. Laminin surface binding sites and metastatic potential of 3LL tumor cells, increased by indomethacin. Biochem. Biophys. Res. Commun. 167, 731-738.
4. Aliño, S.F., Iruarrizaga, A., Alfaro, J., Almena, A., Lejarreta, M., Unda, F.J., 1991. Anti-metastatic effects of liposome entrapped indomethacin. Life Sci. 48, 149-154.
5. Aliño, S.F., Unda, F.J., Iruarrizaga, A., Alfaro, J., Hilario, E., Pérez-Yarza, G., Bobadilla, M., Lejarreta, M., 1992. Efficacy of liposome-encapsulated indomethacin in response against metastatic 3LL and B16F1 tumor cells. Lab. Invest. 66, 671-679.
6. Al-Saleem, T., Ali, Z.S., Qassab, M., 1980. Skin cancers in Xeroderma pigmentosum - response to indomethacin and steroids. Lancet 2, 264-265.
7. Ben-Efraim, S., 1992. Interactions between macrophage cytokines and eicosanoids in expression of anti-tumor activity. Mediators of Inflammation 1, 295-308.
8. Bennett, A., Carroll, M.A., Melhuish, P.B., Stamford, I.F., 1985. Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin. Br. J. Cancer 52, 245-249.
9. Brenan, M., Parish, C.R., 1988. Automated fluorimetric assay for T-cell cytotoxicity. J. Immunol. Methods 112, 121-131.
10. Connolly, J.M., Liu, X.H., Rose, D.P., 1996. Dietary linoleic acid-stimulated human breast cancer cell growth and metastases in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. Nutr. Cancer 25, 234-240.
11. Fidler, I.J., 1990. Critical factors in the biology of human cancer metastases. Cancer Res. 50, 6130-6138.
12. Fulton, A.M., 1987. Interaction of natural effector cells and prostaglandins in the control of metastasis. J. Natl. Cancer Inst. 78, 735-741.
13. Fulton, A.M., Heppner, G.H., 1985. Relationships of prostaglandin E and natural killer sensitivity to metastatic potential in murine mammary adenocarcinomas. Cancer Res. 45, 4779-4784.
14. Fulton, A.M., Levi, J.G., 1980. Inhibition of murine tumor growth and prostaglandin synthesis by indomethacin. Int. J. Cancer 26, 669-673.
15. 2 receptor in mammary tumor metastases. Cancer Res. 51, 2047-2050.
16. Lupulesku, A., 1996. Prostaglandins, their inhibitors and cancer. Prostaglandins Leukotrienes Essent. Fatty Acids 54, 83-94.
17. Lynch, N.R., Castes, M., Astoin, M., Salomon, J.C., 1978. Mechanism of inhibition of tumor-growth by aspirin and indomethacin. Br. J. Cancer 38, 503-512.
18. Noguchi, M., Rose, D.P., Earashi, M., Miyazaki, I., 1995. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. Oncology 52, 265-271.
19. Ochoa, A.C., Zea, A.H., Ghosh, P., Longo, D.L., 1994. Alterations in signal transduction in T-cells from cancer patients. Cancer Vaccines: Structural Basis for Vaccine Development. Int. Symp. Cancer Res. Inst., New York.
20. Panje, W.R., 1981. Regression of head and neck carcinoma with a prostaglandin synthesis inhibitor. Arch. Otolaryngol. 107, 658-663.
21. Planchon, P., Veber, N., Magnien, V., Prevost, G., Starzec, A.B., Israel, L., 1995. Evidence for separate mechanisms of anti-proliferative action of indomethacin and prostaglandin on MCF-7 breast cancer cells. Life Sci. 57, 1233-1240.
22. Plescia, O.J., Smith, A.H., Grinwich, K., 1975. Subversion of immune system by tumor cells and role of prostaglandins. Proc. Natl. Acad. Sci. USA 72, 1848-1851.
23. Powles, T.J., Clark, S.A., Easty, D.M., Easty, G.C., Neville, A.M., 1973. Inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcemia in rat with Walker tumor and its possible application to human breast cancer. Br. J. Cancer 28, 316-321.
24. Rolland, P.H., Martin, P.M., Jaequemier, J., Rolland, A.M., Toga, M., 1980. Prostaglandins in human breast cancer: evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells. J. Natl. Cancer Inst. 64, 1061-1066.
25. Shiff, S.J., Koutsos, M.I., Quav, L., Rigas, B., 1996. Non-steroidal anti-inflammatory drugs inhibit the proliferation of colon adenocarcino cells: effects on cell cycle and apoptosis. Exp. Cell Res. 222, 179-188.
26. Sugarbaker, E.V., Weingard, D.N., Roseman, J.M., 1982. Observations on cancer metastases. In: Liota, L.A., Hart, I.R. (Eds.), Cancer Invasion and Metastases. Martinus Nijhoff, Boston, MA, pp. 427-465.
27. Watson, G.A., Fu, Y.X., Lopez, D.M., 1991. Splenic macrophages from tumor-bearing mice co-expressing MAC-1 and MAC-2 antigens exert immunoregulatory functions via two distinct mechanisms. J. Leukocyte Biol. 49, 126-138.