Mutation in the α-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with Lewy bodies

Experimental Neurology

Volumn 153, Issue 1, 1998, Pages 164-166

  Higuchi, Susumu ^a   Arai, Hiroyuki ^b   Matsushita, Sachio ^a   Matsui, Toshifumi ^b   Kimpara, Teiko ^b   Takeda, Atsushi ^b   Shirakura, Katsuyuki ^a  

^a KURIHAMA NATIONAL HOSPITAL   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alzheimer's disease; Dementia with Lewy bodies; Missense mutation; Parkinson's disease; synuclein

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; DEMENTIA; GENE MUTATION; GENETIC SUSCEPTIBILITY; IMMUNOHISTOCHEMISTRY; LEWY BODY; MISSENSE MUTATION; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0031710057     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6868     Document Type: Article

References (13)

1. Heintz, N., and H. Zoghbi. 1997. α-Synuclein - A link between Parkinson and Alzheimer diseases? Nature Genet. 16: 325-327.
2. Hughes, A. J., Y. Ben-Shlomo, L. Kilford, and A. J. Lees. 1992. What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study. Neurology. 42: 1142-1146.
3. Hughes, A. J., S. E. Daniel, L. Kilford, and A. J. Lees. 1992. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry 55: 181-184.
4. McKeith, I. G., D. Galasko, K. Kosaka, E. K. Perry, D. W. Dickson, L. A. Hansen, D. P. Salmon, J. Lowe, S. S. Mirra, E. J. Byrne, G. Lennox, N. P. Quinn, J. A. Edwardson, P. G. Ince, C. Bergeron, A. Burns, B. L. Miller, S. Lovestone, D. Collerton, E. N. Jansen, C. Ballard, R. A. de Vos, G. K. Wilcock, K. A. Jellinger, and R. H. Perry. 1996. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop. Neurology 47: 1113-1124.
5. McKhann, G., D. Drachman, M. Folstein, R. Katzman, D. Price, and E. M. Stadlan. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944.
6. Polymeropoulos, M. H., C. Lavedan, E. Leroy, S. E. Ide, A. Dehejia, A. Dutra, B. Pike, H. Root, J. Rubenstein, R. Boyer, E. D. Stenroos, S. Chandrasekharappa, A. Athanassiadou, T. Papapetropoulos, W. G. Johnson, A. M. Lazzarini, R. C. Duvoisin, G. D. Iorio, L. I. Golbe, and R. L. Nussbaum. 1997. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047.
7. Spillantini, M. G., M. L. Schmidt, V. M. Y. Lee, J. Q. Trojanowski, R. Jakes, and M. Goedert. 1997. α-Synuclein in Lewy bodies. Nature 388: 839-840.
8. Ueda, K., H. Fukushima, E. Masliah, Y. Xia, A. Iwai, M. Yoshimoto, D. A. C. Otero, J. Kondo, Y. Ihara, and T. Saitoh. 1993. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 90: 11282-11286.
9. Scott, W. K., J. M. Stajich, L. H. Yamaoka, M. C. Speer, J. M. Vance, A. D. Roses, M. A. Periak-Vance, and Deane Laboratory Parkinson Disease Research Group. 1997. Genetic complexity and Parkinson's disease. Science 277: 387-388.
10. Gasser, T., B. Muller-Myhsok, Z. K. Wszolek, A. Durr, J. R. Vaughan, V. Bonifati, G. Meco, B. Bereznai, R. Oehlmann, Y Agid, A. Brice, and N. Wood. 1997. Genetic complexity and Parkinson's disease. Science 277: 388-389.
11. Chan, P., C. M. Tanner, X. Jiang, and W. Langston. 1997. Failure to find the α-synuclein gene missense mutation (G209A) in 100 patients with younger onset Parkinson's disease. Neurology 50: 513-514.
12. Farrer, M., F. W.-D. Vrieze, R. Crook, L. Boles, J. Perez-Tur, J. Hardy, W. G. Johnston, J. Steele, D. Maraganore, K. Gwinn, and T. Lynch. 1998. Low frequency of α-synuclein mutations in familial Parkinson's disease. Ann. Neurol. 43: 394-397.
13. Kitada, T., S. Asakawa, N. Hattori, H. Matsumine, Y. Yamamura, S. Minoshima, M. Yokochi, Y Mizuno, and N. Shimizu. 1998. Mutation in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392: 605-608.