Capturing novel mouse genes encoding chromosomal and other nuclear proteins

Journal of Cell Science

Volumn 111, Issue 17, 1998, Pages 2575-2585

  Tate, Peri ^a,c   Lee, Muriel ^a   Tweedie, Susan ^b   Skarnes, William C ^c   Bickmore, Wendy A ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

geo; Heterochromatin; Kinase; Splicing; Ubiquitin ligase

Indexed keywords

NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CHROMOSOME; GENE FUNCTION; GENE SEQUENCE; MOUSE; NONHUMAN; NUCLEOLUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPORTER GENE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHROMOSOMAL PROTEINS, NON-HISTONE; EMBRYO; GENES; GENETIC TECHNIQUES; LIGASES; MALE; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR ENVELOPE; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-SERINE-THREONINE KINASES; RIBONUCLEOPROTEIN, U4-U6 SMALL NUCLEAR; RNA SPLICING; STEM CELLS; UBIQUITIN-PROTEIN LIGASES;

EID: 0031709906     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Aasland, R., Gibson, T. J. and Stewart, A. F. (1995). The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci. 20, 56-59.
2. Aasland R. and Stewart A. F. (1995). The chromo shadow domain, a second chromodomain in heterochromatin-binding protein l, HP1. Nucleic Acids Res. 23, 3168-3173.
3. Alkema, M. J., Bronk, M., Verhoeven, E., Otte, A., van't Veer, L., J., Berns. A. and van Lohufzen, M. (1997). Identification of Bmi-interacting proteins as constituents of a multimeric mammalian Polyeomb complex. Genes Dev. 11, 226-240.
4. Altschul, S. K, Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W. and Lipman, D. J. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402.
5. Baker, R. K., Haendel, M. A., Swanson, B. J., Shambaugh, J. C., Micales, B. K. and Lyons, G. K. (1997). In vitro preselection of gene-trapped embryonic stem cell clones for characterizing developmentally regulated penes in the mouse. Div. Biol. 185, 201-214.
6. Burford, D. (1996). Molecular mechanisms of the protein serine/ threoninc phosphatases. Trends Biochwn Sci. 21, 407-412.
7. Burns, N., Grimnade, B., Ross-Macdonald, P. B., Choi, E-Y, Finberg, K., Roeder GS and Snyder, M. (1994). Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae. Genes Dev. 8, 1087-1105.
8. Caceres, J. F., Misteli, T., Screaton, G. R., Spector, D. L. and Krainer, A. R. (1997). Role of the modular domains of SR proteins in suhnuclear localization and alternative splicing specificity. J. Cell Biol. 138, 225-238.
9. Chen, Y. H., Chen, M. X., Alessi, D. R., Campbell, D. G., Shanahan, C., Cohen, P. and Cohen, P. T. W. (1994). Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M. FEBS Lett. 356, 51-55.
10. Chowdury, K., Bonaldo, P., Torres, M., Stoykova, A. and Gruss, P. (1997). Evidence for the stochastic integration of gene trap vectors into the mouse germline. Nucleic Acids Res. 25, 1531-1536.
11. WAF1. Science 277, 1996-2000.
12. Colwill, K., Pawson, T., Andrews, B., Prasad, J., Manley, J. L., Bell, J. C. and Ducan, P. I. (1996). The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J. 15, 265-275.
13. Cross, S. H., Lee, M., Clark, V. H., Craig, J. M., Bird, A. P. and Bickmore, W. A. (1997). The chromosomal distribution of CpG islands in the mouse: Evidence for genome scrambling in the rodent lineage. Genomics 40, 454-461.
14. Dingwall C. and Laskey, R. (1991). Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16, 478-481.
15. Durfee, T., Mancinl, M. A., Jones, D., Elledge, S. J. and Lee, W.-H. (1994). the amino-tenninal regions of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. J. Cell Biol. 127, 609-622.
16. Fan, F., Liu, C.-P., Korobova, O., Heyting, C., Offenberg, H. H., Trump, G. and Arnheim, N. (1997). cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiation. Genomics 40, 444-453.
17. Freidrich G. and Soriano, P. (1991). Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5,1513-1523.
18. Fu, X. D. (1995). The superfamily of arginine/serine-rich splicing factors. RNA 1, 663-680.
19. Gooderham, G. and Jeppesen, P. (1983). Chinese hamster metaphase chromosomes isolated under physiological conditions: a partial characterization of associated nonhistone proteins and protein cores. Exp. Cell Res. 144, 1-14.
20. Gossler, A., Joyner, A. L., Rossant, J. and Skarnes, W. C. (1989). Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244, 463-465.
21. Gross, T., Lutzelberger, M., Wiegmann, H., Klingenhoff, A., Sheno, S., Kaufer, N. F. (1997). Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. Nucleic Acids Res. 25, 1028-1035.
22. Gui, J.-F., Lane, W. S. and Fu, X.-D. (1994). A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature 369, 678-682.
23. Hicks, G. G., Shi, E.-g., Li, X.-M., Li, C.-H., Pawlak, M. and Ruley, H. E. (1977). Functional genomics in mice by tagged sequence mutagenesis. Nature Genet. 16, 338-344.
24. Hobert, O., Sures, I., Ciossek, T., Fuchs, M. and Ullrich, A. (1996). Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene. Mech. Dev. 55, 171-184.
25. Holzschu, D., Lapierre, L., Neubaum, D. and Mark, W. H. (1997). A molecular strategy designed for the rapid screening of gene traps based on sequence identity and gene expression pattern in adult mice. Transgenic Res. 6, 97-106.
26. Huang, S., Deerinck, T. J., Ellisman, M. H. and Spector, D. L. (1997). The dynamic organization of the perinucleolar compartment in the cell nucleus. J. Cell Biol. 137, 965-974.
27. Keohane, A. M., O'Neill, L. P., Belyaev, N. D., Lavender, J. S. and Turner, B. M. (1996). X-inactivalion and histone H4 acetylation in embryonic stem cells. Dev. Biol. 180, 618-630.
28. Kim, E., Du, L., Bregman, D. B. and Warren, S. L. (1997). Splicing factors associate with hyperphosphoryluted RNA polymerase II in the absence of pre-mRNA. J. Cell Biol. 136, 19-28.
29. Kipling, D., Mitchel, A. R., Masumoto, H., Wilson, H. E., Nicol, L. and Cooke, H. J. (1995). CenP-B binds a novel centromerie sequence in the Asian Mouse Mus Caroli. Mol. Cell Biol. 15, 4009-4020.
30. Lavery, D. J. and Schibler, U. (1993). Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBF. Genes Dev. 7, 1871-1884.
31. Lee, J. W., Choi, H. S., Gyuris, J., Brent, R. and Moore, D. D. (1995). Two classes of proteins dependent on either the presence or absence of thyroidhormone for interaction with the thyroid-hormone receptor. Mol. Endocrinol. 9, 243-254.
32. Leonhardt, H., Page, A. W., Weier, H.-U. and Bestor, T. H. (1992). A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71, 865-873.
33. Lerner, E. A., Lerner, M. R., Janeway, L. A. and Steitz, J. A. (1981). Monoclonal antibodies to nucleic acid containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Nat. Acad Sci. USA 78, 2737-2741.
34. Lewis, J. D., Meehan, R. R., Henzel, W. J., Maurer-Fogy, I., Jeppesen, P., Klein, F. and Bird, A. (1992). Purification, sequence and cellular localization of a novel chromosomal protein that binds to methylated DNA Cell 69, 905-914.
35. Morin, P. E., Awrey, D. E., Edwards, A. M., Arrowsmith, C. H. (1996). Elongation factor TFIIS contains three structural domains: solution structure of domain II Proc. Nat. Acad. Sci. USA 93, 10604-10608.
36. Muller, D., Rehbein, M., Baumeister, H. and Richter, D. (1992). Molecular characterization of a novel rat protein structurally related to poly(A) binding proteins and the 70K protein of the U1 small nuclear ribonucleoprotein particle (snRNP). Nucleic Acids Res. 20, 1471-1475.
37. Nan, X. S., Tate, P., Li, E. and Bird, A. (1996). DNA methylation specifies chromosomal localization of MeCP2. Mol. Cell Biol. 16, 414-421.
38. Nyman, U., Hallman, H., Hadlaczky, G., Pettersson, I., Sharp, E. and Ringertz, N. R. (1986). Intranuclear localization of snRNP antigens. J. Cell Biol. 102, 137-144.
39. Rattner, J. B., Hendzel, M. J., Sommer Furbee, C., Muller, M. T. and Bazett-Jones, D. P. (1996). Topoisomcrase II α is associated with the mammalian centromere in a cell cycle - and species-specific manner and is required for proper centromere/kinetochore structure. J. Cell Biol. 134, 1097-1107.
40. Reyes, J. C., Muchard, C. and Yaniv, M. (1997). Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix. J. Cell Biol. 137, 263-274.
41. Scheffner, M., Nuber, U., Huibregtse, J. M. (1995). Protein ubiquitination involving an E1-E2-E3 ubiquitin thioester cascade. Nature 373, 81-83.
42. Schmidt-Zachmann, M. S., Knecht, S. and Kramer, A. (1998). Molecular characterization of a novel, widespread nuclear protein that colocalizes with spliceosome components. Mol. Biol. Cell 9, 143-160.
43. Singh, P. B., Miller, J. R., Pearce, J., Kothary, R., Burton, R. D., Paro, R., James, T. C. and Gaunt, S. J. (1991). A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 19, 789-793.
44. Skarnes, W. C., Auerbach, B. A. and Joyner, A. L. (1992). A gene trap approach in mouse embryonic stem cells: the lacZ reporter is activated by splicing, reflects endogeneous gene expression, and is mutagenic in mice. Genes Dev. 6, 903-918.
45. Skarnes, W. C., Moss, J. E., Hurtley, S. M. and Beddington, R. S. P. (1995). Capturing genes encoding membrane and secreted proteins important for mouse development. Proc. Nat. Acad. Sci. USA 92, 6592-6596.
46. Spector, D. L. (1993). Macromolecular domains within the cell nucleus. Annu. Rev. Cell Biol. 9, 265-315.
47. Spector, D. L., Fu, X.-D. and Maniatis, T. (1991). Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J. 10, 3467-3481.
48. Springer, P. S., McCombie, W. R., Sundaresan, V. and Martienssen, R. A. (1995). Gene-trapping of PROLIFERA, an essential MCM2-3-5-like gene in Arabidopsis. Science 268, 877-880.
49. Takeuchi, M. and Yanagida, M. (1993). A mitotic role for a novel fission yeast protein kinase dskl with cell cycle stage dependent phosphorylation and localization. Mol. Biol. Cell. 4, 247-260.
50. Tate, P., Skarnes, W. and Bird, A. (1996). The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse. Nature Genet. 12, 205-208.
51. Townley, D. J., Avery, B. J., Rosen, B. and Skarnes, W. C. (1997). Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice. Genome Ren. 7, 293-298.
52. Wilson, V., Manson, L., Skarnes, W. C. and Beddington, R. S. P. (1995). The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. Development 121, 877-886.
53. Wreggett, K. A., Hill, F., James, P. S., Hutchings, A., Butcher, G. W. and Singh, P. B. (1994). A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin. Cytogenet. Cell Genet. 66, 99-103.
54. Wurst, W., Rossant, J., Prideaux, V., Kownacka, M., Joyner, A., Hill, D. P., Guillemot, F., Gasca, S., Cade, D., Auerbach, A. and Ang, S.-L. (1995). A large-scale gene trap for insertional mutations in developmentally regulated genes in mice. Genetics 139, 889-899.
55. Zambrowicz, B. P., Freidrich, G. A., Buxton, E. C., Lilleberg, S. L., Person, C. and Sands, A. T. (1998). Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature 392, 608-611.