Relative activities of methyl methanesulphonate (MMS) as a genotoxin, clastogen and gene mutagen to the liver and bone marrow of Muta(TM)Mouse mice

Environmental and Molecular Mutagenesis

Volumn 32, Issue 2, 1998, Pages 163-172

  Tinwell, H ^a   Lefevre, P A ^a   Ashby, J ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Deletion mutations; Mutation mechanisms

Indexed keywords

CLASTOGEN; MUTAGENIC AGENT;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW TOXICITY; CARCINOGENICITY; CELL DIVISION; DOSE RESPONSE; GENE DELETION; GENE FREQUENCY; GENOTOXICITY; MICRONUCLEUS; MOUSE; MUTAGENICITY; NONHUMAN; NUCLEOTIDE SEQUENCE;

2-ACETYLAMINOFLUORENE; ANIMALS; BONE MARROW; DIMETHYLNITROSAMINE; DNA DAMAGE; LIVER; MALE; METHYL METHANESULFONATE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MICE, TRANSGENIC; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0031709715     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1998)32:2<163::AID-EM12>3.0.CO;2-Q     Document Type: Article

References (26)

1. Ashby J (1987): The efficient preparation of corn oil suspensions. Mutat Res 187:45.
2. Ashby J, Tinwell H (1994): A sequential approach to testing with the rodent bone marrow micronucleus assay - Obviation of the need for statistical analyses of data. Mutat Res 327:49-55.
3. Ashby J, Lefevre PA, Burlinson B, Penman MG (1985): An assessment of the in vitro rat hepatocyte DNA repair assay. Mutat Res 156:1-18.
4. Ashby J, Tinwell H, Glover P, Poorman-Allen P, Krehl R, Callander RD, Clive D (1994): Potent mutagenicity of the human carcinogen etoposide to mouse bone marrow cells and mouse lymphoma L5178Y cells. Environ Mol Mutagen 24:51-60.
5. Ashby J, Gorelick NJ, Shelby MD (1997): Mutation assays in male germ cells from transgenic mice: Overview of study and conclusions. Mutat Res 388:111-122.
6. CSGMT (Collaborative Study Group for the Micronucleus Test of the Japanese Environmental Mutagen Society) (1986): Sex differences in the micronucleus test. Mutat Res 172:151-163.
7. Ehling UH, Neuhauser-Klaus A (1990): Induction of specific locus and dominant lethal mutation in male mice in the low dose range by MMS. Mutat Res 230:61-70.
8. Ehling UH, Gumming RB, Mailing HV (1968): Induction of dominant lethal mutations by alkylating agents in male mice. Mutat Res 5:417-428.
9. Ehling UH, Doherty DG, Mailing HV (1972): Differential spermatogenic response of mice to the induction of dominant lethal mutations by n-propyl methanesulphonate and isopropyl methanesulphonate. Mutat Res 15:175-184.
10. - plasmid. Nucleic Acids Res 20:3254.
11. IARC (International Association for Research on Cancer) (1974): Monograph 7 Methyl Methanesulphonate. Lyon, France: IARC, 253-260.
12. 6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines. Environ Mol Mutagen 22:283-292.
13. Lefevre PA, Ashby J (1989): Evaluation of dichloromethane as an in- ducer of DNA synthesis in the B6C3F1 mouse liver. Carcinogenesis 10:1067-1072.
14. Lefevre PA, Ashby J (1992): Mitogenic activity of quinoline to the rat, mouse and guinea pig liver: Empirical correlations with hepatic carcinogenicity. Environ Mol Mutagen 20:39-43.
15. - phages based on galactose sensitivity. Transgen Res 3:67-69.
16. Mirsalis JC, Provost GS, Matthews CD, Hammer RT, Schindler JE, O'Loughlin KG, MacGregor JT, Short JM (1993): Induction of hepatic mutations in lacl transgenic mice. Mutagenesis 8:265-271.
17. Mirsalis JC, Tyson CK, Loh EN, Steinmetz KL, Bakke JP, Hamilton CM, Spak DP, Spalding JW (1985): Induction of hepatic cell proliferation and unscheduled DNA synthesis in mouse hepatocytes following in vivo treatment. Carcinogenesis 6:1521-1524.
18. Morrison V, Tinwell H, Ashby J (1995): Consideration of the liver of embryonic lacZ transgenic mice as an analogue of the mouse coat colour spot test: Preliminary data and technical problems. Mutat Res 329:107-112.
19. Shibuya T, Morimoto K (1993): A review of genotoxicity of 1-ethyl-1-nitrosourea. Mutat Res 297:3-38.
20. TM- Mouse). Mutat Res 395:75-82.
21. Tinwell H, Ashby J (1989): Comparison of acridine orange and giemsa stains in several mouse bone marrow studies including a triple dose experiment. Mutagenesis 4:477-482.
22. - transgenic mouse mutation assay to DMN: Comparisons with the corresponding Big Blue® (lac I) responses. Mutat Res 307:169-173.
23. Tinwell H, Lefevre PA, Ashby J (1994b): Mutation studies with dimethylnitrosamine in young and old laclI transgenic mice. Mutat Res 307:501-508.
24. TM Mouse (lacZ) transgenic mouse mutation assays using common liver samples. Mutat Res 335:185-190.
25. Tsuyoshi T, Takeuchi M, Hironi H, Masamoto Y (1989): Micronucleus test with methyl methanesulphonate administered by intraperitoneal injection and oral gavage. Mutat Res 223:383-386.
26. Vogel E, Natarajan AT (1979): The relation between reaction kinetics and mutagenic action of mono-functional alkylating agents in higher eukaryotic systems. I. Recessive lethal mutations and translocations in Drosophila. Mutat Res 62:51-100.