Parathyroid hormone induces bone resorption in human peripheral blood mononuclear cells

International Journal of Experimental Pathology

Volumn 79, Issue 4, 1998, Pages 223-233

  Fuller, K ^a   Chambers, T J ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Bone resorption; M CSF; Monocytes; Osteoclasts; PTH

Indexed keywords

CALCITRIOL; COLONY STIMULATING FACTOR 1; PARATHYROID HORMONE;

ANIMAL TISSUE; ARTICLE; CATTLE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; CORTICAL BONE; HORMONAL REGULATION; HUMAN; HUMAN CELL; MACROPHAGE; MONONUCLEAR CELL; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL;

ANIMALS; BONE AND BONES; BONE RESORPTION; CALCITRIOL; CELL ADHESION; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; CULTURE TECHNIQUES; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; OSTEOCLASTS; PARATHYROID HORMONE;

EID: 0031709540     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.1998.00020.x     Document Type: Article

References (32)

1. ATHANASOU N.A., QUINN J., HORTON M.A. & MCGEE J.O. (1990) New sites of cellular vitronectin receptor immunoreactivity detected with osteoclast-reacting monoclonal antibodies 13C2 and 23C6. Bone Miner. 8, 7-22.
2. BIRCH M.A., HIRST J.P., BOOTHROYD B., WALSH C.A. & GALLAGHER J.A. (1990) Assessment of the resorptive capacity of multinucleate cells from human bone marrow culture. Calcif. Tissue Int. 46 (Suppl. 2), A57.
3. CHAMBERS T.J. (1985) The pathobiology of the osteoclast. J. Clin. Pathol. 38, 241-252.
4. CHAMBERS T.J., MCSHEEHY P.M.J., THOMSON B.M. & FULLER K. (1985) The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones. Endocrinology. 116, 234-239.
5. CHAMBERS T.J., OWENS J.M., HATTERSLEY G., JAT P.S. & NOBLE M.D. (1993) Generation of osteoclast-inductive and osteoclastogenic cell lines from the H-2KbtsA58 transgenic mouse. Proc. Natl. Acad. Sci. USA. 90, 5578-5582.
6. CHAMBERS T.J., REVELL P.A., FULLER K. & ATHANASOU N.A. (1984) Resorption of bone by isolated rabbit osteoclasts. J. Cell. Sci. 66, 383-399.
7. FLANAGAN A.M., HORTON M.A., DOREY E.L., COLLINS D.A., EVELY R.S., MOSELEY J.M., FIRKIN F.C., CHAMBERS T.J., HELFRICH M.H. & MARTIN T.J. (1992) An assessment of the ability of human bone marrow cultures to generate osteoclasts. Int. J. Exp. Pathol. 73, 387-401.
8. FUJIKAWA Y., QUINN J.M.W., SABOKBAR A., MCGEE J.O.D. & ATHANASOU N.A. (1996a) The human osteoclast precursor circulates in the monocyte fraction. Endocrinology. 137, 4058-4060.
9. FUJIKAWA Y., SABOKBAR A., NEALE S. & ATHANASOU N.A. (1996b) Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis. Ann. Rheum. Dis. 55, 816-822.
10. GRIGORIADIS A.E., WANG Z.-Q., CECCHINI M.G., HOFSTETTER W., FELIX R., FLEISCH H.A. & WAGNER E.F. (1994) c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science. 266, 443-448.
11. HATTERSLEY G. & CHAMBERS T.J. (1989a) Calcitonin receptors as markers for osteoclastic differentiation: correlation between generation of bone-resorptive cells and cells that express calcitonin receptors in mouse bone marrow cultures. Endocrinology. 125, 1606-1612.
12. HATTERSLEY G. & CHAMBERS T.J. (1989b) Generation of osteoclasts from hemopoietic cells and a multipotential cell line in vitro. J. Cell. Physiol. 140, 478-482.
13. HORTON M.J. & HELFRICH M.H. (1992) Antigenic markers of osteoclasts. In Biology and Physiology of the Osteoclast. Ed B.R. Rifkin & C.V. Gay. Boca Raton: CRC Press, pp. 33-54.
14. HORTON M.A., LEWIS D., MCNULTY K., PRINGLE J.A.S. & CHAMBERS T.J. (1985) Monoclonal antibodies to osteoclastomas (giant cell bone tumours): definition of osteoclast-specific cellular antigens. Cancer Res. 45, 5663-5669.
15. IOTSOVA V., CAAMANO J., LOY J., YANG Y., LEWIN A. & BRAVO R. (1997) Osteopetrosis in mice lacking NF-KB1 an NF-KB2. Nat. Med. 3, 1285-1289.
16. KANEHISA J. & HEERSCHE J.N.M. (1988) Osteoclastic bone resorption: In vitro analysis of the rate of resorption and migration of individual osteoclasts. Bone. 9, 73-79.
17. KERBY J.A., HATTERSLEY G., COLLINS D.A. & CHAMBERS T.J. (1992) Derivation of osteoclasts from hematopoietic colony-forming cells in culture. J. Bone Miner. Res. 7, 353-362.
18. MANOLAGAS S.C. (1995) Bone marrow, clastic, and blastic cell system: Quo vadis. Calcif. Tissue Int. 56 (Suppl. 1), S52.
19. MARKS S.C. (1983) The origin of the osteoclast. J. Oral Pathol. 12, 226-256.
20. MURRILLS R.J., SHANE E., LINDSAY R. & DEMPSTER D.W. (1989) Bone resorption by isolated human osteoclasts in vitro: effects of calcitonin. J. Bone Miner. Res. 4, 259-268.
21. NICHOLSON G.C., MOSELEY J.M., SEXTON P.M., MENDELSOHN F.A.O. & MARTIN T.J. (1986) Abundant calcitonin receptors in isolated rat osteoclasts. J. Clin. Invest. 78, 355-360.
22. PACIFICI R. (1995) Cytokines and osteoclast activity. Calcif. Tissue Int. 56 (Suppl. 1), S27-S28.
23. QUINN J.M.W., SABOKBAR A. & ATHANASOU N.A. (1996) Cells of the mononuclear phagocyte series differentiate into osteoclastic lacunar bone resorbing cells. J. Pathol. 179, 106-111.
24. ROODMAN G.D. (1995) Application of bone marrow cultures to the study of osteoclast formation and osteoclast precursors in man. Calcif. Tissue Int. 56 (Suppl. 1), S22.
25. ROUSSEL M.F., SHURTLEFF S.A., DOWNING J.R. & SHERH C.J. (1990) A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes. Proc. Natl. Acad. Sci. USA. 87, 6738-6742.
26. SARMA U. & FLANAGAN A.M. (1996) Macrophage colony-stimulating factor induces substantial osteoclast generation and bone resorption in human bone marrow cultures. Blood. 88, 2531-2540.
27. SCHEVEN B.A.A., VISSER J.W.M. & NIJWEIDE P.J. (1986) In vitro osteoclast generation from different bone marrow fractions, including a highly enriched haemopoietic stem cell population. Nature. 321, 79-81.
28. SUDA T., TAKAHASHI N. & MARTIN T.J. (1995) Modulation of osteoclast differentiation: update. In Endocrine Reviews Monographs vol. 4. Eds D.D. Bikle & A. Negrovilar. Bethesda, MD: Endocrine Society. pp. 266-270.
29. TAKAHASHI N., YAMANA H., YOSHIKI S., ROODMAN D.G., MUNDY G.R., JONES S.J., BOYDE A. & SUDA T. (1988) Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse marrow cultures. Endocrinology. 122, 1373-1382.
30. UDAGAWA N., TAKAHASHI N., AKATSU T., TANAKA H., SASAKI T., NISHIHARA T., KOGA T., MARTIN T.J. & SUDA T. (1990) Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc. Natl. Acad. Sci. USA. 87, 7260-7264.
31. WEIR E.C., HOROWITZ M.C., BARON R., CENTRELLA M., KACINSKI B.M. & INSOGNA K.L. (1993) Macrophage colony-stimulating factor release and receptor expression in bone cells. J. Bone Miner. Res. 8, 1507-1518.
32. WEIR E.C., LOWIK C.W., PALIWAL I. & INSOGNA K.L. (1996) Colony stimulating factor-I plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone-related protein. J. Bone Miner. Res. 11, 1474-1481.