Long-term ethanol consumption selectively impairs ganglioside pathway in rat brain

Alcoholism: Clinical and Experimental Research

Volumn 22, Issue 6, 1998, Pages 1220-1226

  Ghosh, Pradeep ^a,b,d   Ender, Ingo ^b   Hale, Eric A ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c Micro Probe Inc   (United States)

^d JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

Author keywords

Chronic Ethanol; Gangliosides; Glycosylation; Rat Brain

Indexed keywords

ALCOHOL; GANGLIOSIDE; GANGLIOSIDE GD 1A; GANGLIOSIDE GD3; GANGLIOSIDE GT 1B; SIALIDASE; SIALYLTRANSFERASE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; ENZYME ACTIVITY; GLYCOSYLATION; GOLGI COMPLEX; LIPID METABOLISM; LONG TERM EXPOSURE; MALE; NERVE CELL MEMBRANE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0031708834     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1998.tb03902.x     Document Type: Article

References (26)

1. Rapport MM, Gorio A: Gangliosides: In neurological and neuromuscular function, in Rapport MM, Gorio A (eds): Development and Repair. New York, Raven Press, 1981
2. Fishman PH, Brady S: Biosynthesis and function of gangliosides. Science 194:906-915, 1976
3. Klemm WR, Foster DM: Effects of chronic alcohol consumption in weanling rats on brain gangliosides. Prog Neuro-Psychopharmacol Biol Psychiatr 10:697-702, 1986
4. Ruan S, Lloyd KO: Glycosylation pathways in the biosynthesis of gangliosides in melanoma and neuroblastoma cells: Relative glycosyltransferase levels determine ganglioside patterns. Cancer Res 52:5725-5731, 1992
5. Tettamanti G, Ghidoni R, Trinchera M: Recent advances in ganglioside metabolism. Indian J Biochem Biophys 25:106-111, 1988
6. Brunngraber E: Neurochemistry of Aminosugar, Thomas GG (ed). Springfield, Charles C Thomas, 1979, pp 410-437
7. Klemm WR, Foster DM: Acute alcohol reduces brain gangliosides. Fed Proc 44:1089, 1985 (abstr)
8. 3H-labeled sialoconjugates from liver and brain of mice in vitro. Alcohol 5:499-503, 1988
9. Ghosh P, Liu QH, Lakshman MR: Long-term ethanol exposure impairs glycosylation of both N- and O-glycosylated proteins in rat liver. Metabolism 44:890-898, 1995
10. Lieber CS, DeCarli LM: The feeding of alcohol liquid diets: Two decades of applications and 1982 update. Alcohol Clin Exp Res 6:523-531, 1989
11. Hale E, Raza SK, Ciecierski R, Ghosh P: Deleterious actions of chronic ethanol treatment on the glycosylation of rat brain clustering. Brain Res 785:158-166, 1998
12. Durrie R, Saito M, Rosenberg A: Glycolipid sialosyltransferase activity in synaptosomes exhibits a product specificity for (2-8)disialosyl lactose ceramide (ganglioside GD3). J Neurosci Res 18:456-487, 1987
13. Trinchera M, Fabbri M, Ghidoni R: Topography of glycosyltransferases involved in the initial glycosylations of gangliosides. J Biol Chem 266:20907-20912, 1991
14. Miyagi T, Tsuiki S: Purification and characterization of cytosolic sialidase from rat liver. J Biol Chem 260:6710-6716, 1985
15. Warren L: The thiobarbituric acid assay of sialic acids. J Biol Chem 234:248-254, 1976
16. Klemm WR, Engen RL: Effects of ethanol on brain sialic acid and 2-deoxyribose in young rats. J Stud Alcohol 40:554-561, 1979
17. Rawat AK: Lipid metabolism in brains from mice chronically-fed ethanol. Res Commun Chem Pathol Pharmacol 8:461-469, 1974
18. Vrbaski SR, Grugic-Injac B, Ristic M: Phospholipid and ganglioside composition in rat brain after chronic intake of alcohol. J Neurochem 42:1235-1239, 1984
19. Vrbaski SR, Ristic M: Cerebellum lipids in rats after chronic ethanol treatment. J Neurochem 44:1868-1872, 1985
20. Klemm WR, Boyles R, Mathew J, Cherian L: Gangliosides, or sialic acid, antagonize ethanol intoxication. Life Sci 43:1837-1843, 1988
21. Cherian L, Mathew J, Klemm WR: Ethanol-induced hydrolysis of brain sialoconjugates in the rat: Effect of sialic acid in antagonizing ethanol intoxication. Alcohol Clin Exp Res 13:435-439, 1989
22. Klemm WR, Engen RL: Biochemical markers of ethanol effects on brain. J Neurosci Res 3:341-352, 1978
23. Ghosh P, Okoh C, Liu QH, Lakshman MR: Effects of chronic ethanol on enzymes regulating sialylation and desialylation of transferrin in rats. Alcohol Clin Exp Res 17:576-579, 1993
24. Xin Y, Lasker JM, Lieber CS: Serum carbohydrate-deficient transferrin: Mechanism of increase after chronic alcohol intake. Hepatology 22:1462-1468, 1995
25. Schengrund C-L, Rosenberg A: Intracellular location and properties of bovine brain sialidase. J Biol Chem 245:6196-6200, 1970
26. Gravotta D, Maccioni HJF: Gangliosides and sialosylglycoconjugates in coated vesicles from bovine brain. Biochem J 225:713-721, 1985