Effects of age on the sensitivity of the rat lens to hexanol in vitro

Journal of Toxicology - Cutaneous and Ocular Toxicology

Volumn 17, Issue 2-3, 1998, Pages 127-139

  Herbert, K L ^a   Dixon, D G ^a   Sivak, J G ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEXANOL;

ANIMAL TISSUE; ARTICLE; CHEMOSENSITIVITY; EYE IRRITATION; LENS; NONHUMAN; OPTICS; RABBIT; TOXICITY TESTING;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0031708548     PISSN: 07313829     EISSN: None     Source Type: Journal    
DOI: 10.3109/15569529809049313     Document Type: Article

References (28)

1. K. A. Stitzel, Eye irritation testing: Introduction and background. J. Toxicol. Cut. Ocular Toxicol. 15: 3:214-218, 1996.
2. D. J. De Sousa, A. A. Rouse, and W. J. Smolon, Statistical consequences of reducing the number of rabbits utilized in eye irritation testing: Data on 67 petrochemicals, Toxicol. Appl. Pharmacol. 76: 234-242, 1984.
3. L. H. Bruner, In Vitro Toxicity Testing: Applications to Safety Evaluation, J. M. Frazier, Ed., New York, Marcel Dekker, Inc., 1992, pp. 149-162.
4. P. H. VanParys, G. H. Deknudt, M. Sysmans, G. Teuns, W. Coussement, and H. Van Cauteren, Evaluation of the bovine corneal opacity-permeability assay as an in vitro alternative to the Draize eye irritation test, Toxicol. In Vitro 7: 471-476, 1993.
5. P. L. Casterton, L. F. Potts, and B. D. Klein, A novel approach to assessing eye irritation potential using the bovine corneal opacity and permeability assay, J. Toxicol. Cut. Ocular Toxicol. 15: 2:146-163, 1996.
6. H. E. Kennah, H. S. Hignet, P. E. Laux, J. D. Dorko, and C. S. Barrow, An objective procedure for quantitating eye irritation based upon changes in corneal thickness, Fund. Appl. Toxicol. 12: 258-268, 1989.
7. M. P. Vinardell and M. Macián, Comparative study of the HET-CAM test and the Draize eye test for assessment of irritancy potential, Toxic. In Vitro 8: 3:467-470, 1994.
8. H. Kojima, A. Hanamura, S. Miyamoto, A. Sato, H. Knoishi, and I. Yoshimura, Evaluation of seven alternative assays on the main ingredients in cosmetics as predictors of Draize irritation scores, Toxic. In Vitro 9: 3:333-340, 1995.
9. H. Spielman, M. Liebsch, F. Moldenhauer, H. G. Holzhütter, and O. de Silva, Modern biostatistical methods for assessing in vitro/in vivo correlation of severely eye irritating chemicals in a validation study of in vitro alternatives to the Draize eye test, Toxic. In Vitro 9: 4:549-556, 1995.
10. R. S. McLaughlin, Chemical burns of the human cornea, Am. J. Ophthalmol. 29: 11:1355-1362, 1946.
11. Y. R. Barishak, Embryology of the Eye and Its Adnexea. Developments in Ophthalmology, Vol. 24. New York, Karger Inc, 1992, pp. 7-10.
12. B. K. Pierscionek and R. C. Augusteyn, Structure/function relationship between optics and biochemistry of the lens, Lens Eye Toxicity Res. 8: 2&3:229-243, 1991.
13. R. C. Tripathi and B. J. Tripathi, Lens morphology, aging, and cataract, J. Gerontol. 38: 3:258-270, 1983.
14. J. R. Kuszak, K. L. Peterson, and H. G. Brown, Electron microscopic observations of the crystalline lens, Microscopy Res. Tech. 33: 441-479, 1996.
15. J. G. Sivak, D. Gershon, A. Dovrat, and J. Weerheim, Computer assisted scanning laser monitor of optical quality of the excised crystalline lens, Vision Res. 26: 11:1873-1879, 1986.
16. J. G. Sivak, K. L. Herbert, and L. Segal, Ocular lens organ culture as a measure of ocular irritancy: The effects of surfactants, Toxicol. Methods 4: 56-65, 1994.
17. J. G. Sivak, K. L. Herbert, and D. Fonn, In vitro ocular irritancy testing of four contact lens solutions, J. Contact Lens Assoc. Ophthalmol. 21: 169-174, 1995.
18. I. Saar, E., Neumann, and D. Gershon, Effects of gentamycin and chloramphenicol on the transparency of cultured rat lenses, Ophthalmic Res. 21: 118-122, 1989.
19. K. L. Herbert and J. G. Sivak, In vitro measure of ocular damage and recovery from aromatics, J. Toxicol. Cut. Ocular Toxicol. 15: 4:331-341, 1996.
20. J. G. Sivak, K. L. Herbert, and A. L. Baczmanski, The use of the cultured bovine lens to measure the in vitro ocular irritancy of ketones and acetates, ATLA 23: 689-698, 1995.
21. J. G. Sivak, D. D. Stuart, K. L. Herbert, J. A. Van Oostrom, and L. Segal, Optical properties of the cultured bovine ocular lens as an in vitro alternative to the Draize eye toxicity test: Preliminary validation for alcohols, Toxicol. Methods 2: 4:280-294, 1992.
22. C. P. Carpenter and H. F. Smyth, Chemical burns of the rabbit cornea, Am. J. Ophthalmol. 29: 11:1363-1372, 1946.
23. J. S. Milton, J. J. Corbet, and P. M. McTeer, Introduction to Statistics, Lexington, MA, D.C. Heath and Co., 1986, p. 216.
24. J. G. Sivak and A. Dovrat, Aging and the optical quality of the rat crystalline lens, Invest. Ophthalmol. Vis. Sci. 24: 9:1162-1166, 1983.
25. E. L. Siew, D. Opalecky, and F. A. Bettleheim, Light scattering of normal human lens. II. Age dependence of the light scattering parameters, Exp. Eye Res. 33: 603-614, 1981.
26. G. L. Walls, The Vertebrate Eye and Its Adaptive Radiation, Cranbrook Institute of Science, Bloomfield Hills, MI, 1942.
27. J. G. Sivak and A. Dovrat, Embryonic lens of the human eye as an optical structure, J. Opt, Phys. Optics 64: 8:599-603, 1987.
28. W. M. Grant and J. S. Schuman, Toxicology of the Eye, 4th ed., Springfield, IL, Charles C. Thomas, 1993, pp. 4-20.