Acute toxicity of ethylene glycol mono-n-butyl ether in the guinea pig

Food and Chemical Toxicology

Volumn 36, Issue 9-10, 1998, Pages 825-829

  Gingell, R ^a   Boatman, R J ^b   Lewis, S ^c  

^a Shell Chemical Co   (United States)

^b EASTMAN KODAK COMPANY   (United States)

^c AMERICAN CHEMISTRY COUNCIL   (United States)

Author keywords

2 butoxyethanol; Acute toxicity; CAS no. 111 76 2; Ethylene glycol butyl ether; Guinea pig; Haemolysis; Species difference

Indexed keywords

ETHYLENE GLYCOL DERIVATIVE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GUINEA PIG; HEMOLYSIS; INHALATION; INTRAVASCULAR HEMOLYSIS; LD 50; MALE; NONHUMAN; SPECIES DIFFERENCE;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMALS; ETHERS; ETHYLENE GLYCOLS; FEMALE; GUINEA PIGS; INJECTIONS, SUBCUTANEOUS; LETHAL DOSE 50; MALE; SOLVENTS;

ANIMALIA; CAVIA; CAVIA PORCELLUS; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

EID: 0031708446     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(98)00047-7     Document Type: Article

References (23)

1. Carpenter C. P., Pozzani U. C., Weil C. S., Nair J. H., Keck G. A. and Smyth J. R. (1956) The toxicity of butyl cellosolve solvent. American Medical Association Archives of Industrial Health 14, 114-131.
2. Corley R. A. (1996) Assessing the risk of hemolysis in humans exposed to 2-butoxyethanol using a physiologically-based pharmacokientic model. Occupational Hygiene 2, 45-55.
3. DOT (1997) Department of Transportation. Code of Federal Regulations. Title 49, part 173132. US Government Printing Office, Washington, DC.
4. Dodd D. E., Snellings W. M., Maronpot R. R. and Ballantyne B. (1983) Ethylene glycol mono-butyl ether: acute, 9 day and 90 day vapor inhalation studies in Fischer 344 rats. Toxicology and Applied Pharmacology 68, 405-414.
5. Duprat P. and Gradiski D. (1979) Percutaneous toxicity of butyl cellosolve (ethylene glycol monobutyl ether). IRCS Medical Science 7, 26.
6. Federal Register (1997) Vol. 62, no. 87, Tuesday 8 May, pp. 24690-24743. Department of Transportation. Hazardous Materials: Harmonization with the United Nations Recommendations, International Maritime Dangerous Codes, and International Civil Aviation Organization's Technical Information. US Government Printing Office, Washington, DC.
7. Ghanayem B. I., Sanchez I. M. and Matthews H. B. (1992) Development of tolerance to 2-butoxyethanol-induced hemolytic anemia and studies to elucidate the underlying mechanism. Toxicology and Applied Pharmacology 112, 198-206.
8. Ghanayem G. I. and Sullivan C. A. (1993) Assessment of the hemolytic activity of 2-butoxyethanol and its major metabolite butoxyacetic acid in various mammals including humans. Human and Experimental Toxicology 12, 305-311.
9. Johanson G. and Bowman A. (1991) Percutaneous absorption of 2-butoxyethanol vapour in human subjects. British Journal of Industrial Medicine 48, 788-792.
10. Johanson G., Kronberg H., Naslund P. H. and Byfalt-Nordquist M. (1986) Toxicokinetics of inhaled 2-butoxyethanol in man. Scandinavian Journal of Work, Environment and Health 12, 594-602.
11. Nachreiner D. J. (1994) Ethylene Glycol Butyl Ether: Acute Vapor Inhalation Toxicity Study in Guinea Pigs. Union Carbide Corporation, Bushy Run Research Center.
12. Roudabush R. L., Terhaar C. J., Fassett D. W. and Dziuba S. P. (1965) Comparative acute effects of some chemicals on the skin of rabbits and guinea pigs. Toxicology and Applied Pharmacology 7, 559-565.
13. Shepard K. P. (1994a) Ethylene Glycol Butyl Ether: Acute Oral Toxicity Study in the Guinea Pig. Toxicological Sciences Laboratory, Eastman Kodak Company.
14. Shepard K. P. (1994b) Ethylene Glycol Butyl Ether: Acute Dermal Toxicity Study in the Guinea Pig. Toxicological Sciences Laboratory, Eastman Kodak Company.
15. Sivarao D. V. and Mehendale H. M. (1995) 2-Butoxyethanol autoprotection is due to resilience of newly formed erythrocytes to hemolysis. Archives of Toxicology 69, 526-532.
16. TSCA (1993) Health Effects Testing Guidelines CFR 40, part 798. US Government Printing Office, Washington, DC.
17. Tyler T. R. (1984) Acute and subchronic toxicity of ethylene glycol monobutyl ether. Environmental Health Perspectives 57, 185-191.
18. Udden M. M. (1996) Effects of butoxyacetic acid on human red cells. Occupational Hygiene 2, 283-292.
19. UN (1997) Ninth Revised Edition of the UN Recommendations. United Nations.
20. Vincent R., Cicolella A., Subra L., Rieger B., Poirot P. and Pierre F. (1993) Occupational exposure to 2-butoxyethanol for workers using window cleaning agents. Applied Occupational and Environmental Hygiene 8, 580-586.
21. Wahlberg J. E. and Boman A. (1979) Comparative percutaneous toxicity of ten industrial solvents in the guinea pig. Scandinavian Journal of Environmental Health 5, 345-351.
22. Weil C. S. (1952) Tables of convenient calculations of medium-effective dose (LD50 or ED50) and instructions in their use. Biometrics 8, 249-263.
23. Werner H. W., Mitchell J. L., Miller J. W. and von Oettingen W. F. (1943) The acute toxicity of vapors of several monoalkyl ethers of ethylene glycol. American Medical Association Journal of Industrial Hygiene and Toxicology 25, 157-163.