Molecular biology and clinical importance of the Ca2+-sensing receptor

Current Opinion in Pediatrics

Volumn 10, Issue 4, 1998, Pages 435-440

  De Luca, Francesco ^a   Baron, Jeffrey ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALCIUM SENSING RECEPTOR; CELL RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE PROTEIN; PARATHYROID HORMONE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

CALCIUM ABSORPTION; CALCIUM HOMEOSTASIS; EXTRACELLULAR CALCIUM; GENE MUTATION; HOMOZYGOSITY; HORMONE RELEASE; HUMAN; HUMAN CELL; HYPERCALCEMIA; HYPERPARATHYROIDISM; HYPOCALCIURIA; KIDNEY CALCIFICATION; KIDNEY FAILURE; MOLECULAR BIOLOGY; NEPHROLITHIASIS; PARATHYROID GLAND; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; TISSUE DISTRIBUTION;

EID: 0031708341     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-199808000-00019     Document Type: Review

References (28)

1. Chattopadhyay N, Mithal A, Brown EM: The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocr Rev 1996, 17:289-307. A comprehensive and authoritative review.
2. Brown EM, Vassilev PM, Hebert SC: Calcium ions as extracellular messengers. Cell 1995, 83:679-682.
3. 2+ and the regulation of secretion in parathyroid cells. FEBS Lett 1986, 203:15-19.
4. Brown EM, Fuleihan GEH, Chen CJ, Kifor O: A comparison of the effects of divalent and trivalent cations on parathyroid hormone release, 3′, 5′-cyclic-adenosine monophosphate accumulation, and the levels of inositol phosphates in bovine parathyroid cells. Endocrinology 1990, 127:1064-1071.
5. 2+-sensing receptor from bovine parathyroid. Nature 1993, 366:575-580.
6. Garrett JE, Capuano IV, Hammerland LG, Hung BCP, Brown EM, Hebert SC, Nemeth EF, Fuller F: Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J Biol Chem 1995, 270:12919-12925.
7. 2+ stimulate accumulation of inositol phosphates in bovine parathyroid cells. FEBS Lett 1987, 218:113-118.
8. 2+ in bovine parathyroid cells and human embryonic kidney (HEK293) cells. J Bone Miner Res 1997, 12:715-725.
9. 2+ and other ions as extracellular (first) messengers. Physiol Rev 1991, 71:371-411.
10. Pearce SHS, Thakker RV: The calcium-sensing receptor: insights into extracellular calcium homeostasis in health and disease. J Endocrinol 1997, 154:371-378.
11. Riccardi D, Park J, Lee WS, Gamba G, Brown EM, Hebert S: Cloning and functional expression of a rat kidney extracellular calcium-sensing receptor. Proc Natl Acad Sci USA 1995, 92:131-135.
12. Garrett JE, Tamir H, Kifor O, Simin RT, Rogers KV, Mithal A, Gagel RF, Brown EM: Calcitonin secreting cells of the thyroid gland express an extracellular calcium-sensing receptor gene. Endocrinology 1995, 136:5202-5211.
13. Chen I, Klingensmith ME, Chattopadhyay N, Kifor O, Butters RR, Soybel DI, Brown EM: Identification and localization of the extracellular calcium-sensing receptor in human breast. J Clin Endocrinol Metab 1998, 83:703-707.
14. Rogers KV, Dunn CK, Hebert SC, Brown EM: Localization of calcium receptor mRNA in the adult rat central nervous system by in situ hybridization. Brain Res 1997, 744:47-56.
15. 2+ on renal function? J Am Soc Nephrol 1995, 6:1530-1540.
16. Sands J, Naruse M, Baum M, Hebert SC, Brown EM, Harris W: An apical extracellular calcium/polyvalent cations-sensing receptor (CaR) regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest 1997, 99:1399-1405.
17. 2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 1993, 75:1297-1303.
18. 2+-sensing receptor. J Biol Chem 1996, 271:19537-19545.
19. Pearce SHS, Bai M, Quinn SJ, Kifor O, Brown EM, Thakker RV: Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells. J Clin Invest 1996, 15,98:1860-1866.
20. Brown EM: Mutations in the calcium-sensing receptor and their clinical implications. Horm Res 1997, 48:199-208.
21. Pollak MR, Brown EM, Estep HL, et al.: Autosomal dominant hypocalcemia caused by a Ca+2-sensing receptor gene mutation. Nat Genet 1994, 8:303-307.
22. Baron J, Winer K, Yanovski JA, Cunningham AW, Laue L, Zimmerman D, Cutler G: Mutations in the Ca+2 sensing receptor gene cause autosomal dominant and sporadic hypoparathyroidism. Hum Molec Genet 1996, 5:601-606. First report demonstrating the wide clinical heterogeneity of hypoparathyroidism due to gain-of-function mutations of the CaR.
23. 2+-sensing receptor mutations.
24. 2+-sensing receptor gene (PCAR1) mutation T151M in isolated autosomal dominant hypoparathyroidism. Hum Genet 1996, 98:129-133.
25. 2+-sensing receptor. J Clin Endocrinol Metab 1997, 82:2710-2715.
26. 2+ and maximal signal transduction. Pediatr Res 1997, 42:443-447.
27. 2+-sensing receptor gene in two Japanese patients with sporadic hypoparathyroidism with hypercalciuria. Hormone Res 1997, 48 (suppl 2):179.
28. Winer KK, Yanovski Ja, Cutler GB: Synthetic human parathyroid hormone 1-34 vs calcitriol and calcium in the treatment of hypoparathyroidism: results of a short-term randomized crossover trial. JAMA 1996, 276:631-636.