Cysteine protease inhibitor, E-64d, prevents in vitro cerulein-induced trypsinogen activation [7]

Gastroenterology

Volumn 115, Issue 3, 1998, Pages 802-

  Otani, T ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALOXISTATIN; CATHEPSIN B; CERULETIDE; CYSTEINE PROTEINASE INHIBITOR; HYDROLASE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; TRYPSIN; TRYPSINOGEN;

ACUTE PANCREATITIS; ANIMAL TISSUE; ENZYME ACTIVATION; LETTER; NONHUMAN; PANCREAS ACINUS; PRIORITY JOURNAL; RAT;

EID: 0031706517     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70181-7     Document Type: Letter

References (17)

1. AK Saluja EA Donovan K Yamanaka Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B Gastroenterology 113 1997 304 310
2. SD Leach IM Modlin GA Scheele Intracellular activation of digestive zymogens in rat pancreatic acini J Clin Invest 87 1991 362 366
3. A Saluja D Steer M Lerch Failure of the cathepsin B inhibitor, E-64, to protect against caerulein and CDE-diet induced pancreatitis (abstr) Pancreas 6 1991 718
4. MA Korsten JW Dlugosz Cathepsin B inhibition in two models of acute pancreatitis Int J Pancreatol 14 1993 149 155
5. LM Greenbaum A Hirshkowitz I Shoichet The activation of trypsinogen by cathepsin B J Biol Chem 234 1959 2885 2890
6. M Charles M Rovery A Guidoni Sur le trypsinogene et la trypsine de porc Biochim Biophys Acta 69 1963 115 129
7. ML Steer J Meldolesi C Figarella Pancreatitis Dig Dis Sci 29 1984 934 938
8. T Hirano A Saluja P Ramarao Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstruction J Clin Invest 87 1991 865 869
9. S Willemer R Bialek G Adler Localization of lysosomal and digestive enzymes in cytoplasmic vacuoles in caerulein pancreatitis Histochemistry 94 1990 161 170
10. J Tooze M Hollinshead G Hensel Regulated secretion of mature cathepsin B from rat exocrine pancreatic cells Eur J Cell Biol 56 1991 187 200
11. T Hirano A Saluja P Ramaro Effects of chloroquine and methylamine on lysosomal enzyme secretion by rat pancreas Am J Physiol 262 1992 G439 G444
12. R Lüthen C Niederau M Niederau Influence of ductal pressure and infusates on activity and subcellular distribution of lysosomal enzymes in the rat pancreas Gastroenterology 109 1995 573 581
13. DJ Krogstad PH Schlesinger Acid vesicle function, intracellular pathogens, and the action of chloroquine against Plasmodium falciparum N Eng J Med 317 1987 542 549
14. SD Leach AJ Bilchik O Karapetian Influence of chloroquine on diet-induced pancreatitis Pancreas 8 1993 64 69
15. S Guillaumes I Blanco A Villanueva Chloroquine stabilizes pancreatic lysosomes and improves survival of mice with diet-induced acute pancreatitis Pancreas 14 1997 262 266
16. MM Lerch AK Saluja R Dawra The effect of chloroquine on two experimental models of acute pancreatitis Gastroenterology 104 1993 1768 1779
17. CL Edelstein ED Wieder MM Yaqoob The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury Proc Natl Acad Sci USA 92 1995 7662 7666