Subtleties in control by metabolic channelling and enzyme organization

Molecular and Cellular Biochemistry

Volumn 184, Issue 1-2, 1998, Pages 311-320

  Kholodenko, Boris N ^a,e   Rohwer, Johann M ^c,d,e   Cascante, Marta ^b,c   Westerhoff, Hans V ^b,e,f  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

^f STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Bacterial phosphotransferase system; Control coefficient; Enzyme enzyme interactions; Macromolecular crowding; Metabolic channelling; Non ideal metabolism

Indexed keywords

ENZYME; GLUCOSE; PHOSPHOTRANSFERASE;

ARTICLE; BACTERIAL MEMBRANE; CELL FUNCTION; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; KINETICS; MACROMOLECULE; METABOLIC REGULATION; NONHUMAN; REACTION ANALYSIS; THERMODYNAMICS;

BACTERIA (MICROORGANISMS);

EID: 0031705794     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-1-4615-5653-4_20     Document Type: Article

References (55)

1. Ovadi J, Srere PA: Channel your energies. Trends Biochem Sci 17: 445-447, 1992
2. Welch GR, Easterby JS: Metabolic channelling versus free diffusion: Transition time analysis. Trends Biochem Sci 19: 193-197, 1994
3. Ovadi J: Physiological significance of metabolite channelling. J Theor Biol 152: 1-22, 1991
4. Keizer J, Smolen P: Mechanisms of metabolite transfer between enzymes: diffusional versus direct transfer. Curr Top Cell Regul 33: 391-405, 1992
5. Westerhoff HV, Welch GR: Enzyme organization and the direction of metabolic flow: Physicochemical considerations. Curr Top Cell Regul 33: 361-390, 1992
6. Kell DB, Westerhoff HV: Catalytic facilitation and membrane bioenergetics. In: GR Welch (ed). Organized Multienzyme Systems. Academic Press, New York, 1985, pp 63-138
7. Minton AP: A molecular model for the dependence of the osmotic pressure of bovine serum albumin upon concentration and pH. Biophys Chem 57: 65-70, 1995
8. Garner M: The consequences of macromolecular crowding for metabolic channelling. In: L Agius, HSA Sherratt (eds). Channelling in Intermediary Metabolism. Portland Press, London, 1997, pp 41-52
9. Kholodenko BN, Westerhoff HV: The macroworld versus the microworld of biochemical regulation and control. Trends Biochem Sci 20: 52-54, 1995
10. Easterby JS: Pathway dynamics and the analysis of metabolite channelling. In: L Agius, HSA Sherratt (eds). Channelling in Intermediary Metabolism. Portland Press, London, 1997, pp 71-90
11. Kacser H, Burns JA: The control of flux. In: DD Davies (ed). Rate Control of Biological Processes. Cambridge University Press, London, 1973, pp 65-104
12. Heinrich R, Rapoport TA: A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur J Biochem 42: 89-95, 1974
13. Kholodenko BN, Molenaar D, Schuster S, Heinrich R, Westerhoff HV: Defining control coefficients in non-ideal metabolic pathways. Biophys Chem 56: 215-226, 1995
14. Westerhoff HV, Arents JC: Two completely rate-limiting steps in one metabolic pathway? The resolution of a paradox using control theory and bacteriorhodopsin liposomes. Biosci Rep 4: 23-31, 1984
15. +-ATPase. Proc Natl Acad Sci USA 90: 8068-8072, 1993
16. Cornish-Bowden A: Fundamentals of Enzyme Kinetics. Portland Press, London, 1995
17. Fell DA, Sauro HM: Metabolic control analysis. The effects of high enzyme concentrations. Eur J Biochem 192: 183-187, 1990
18. Kacser H, Sauro HM, Acerenza L: Enzyme-enzyme interactions and control analysis. 1. The case of non-additivity: Monomer-oligomer associations. Eur J Biochem 187: 481-491, 1990
19. Sauro HM, Kacser H: Enzyme-enzyme interactions and control analysis. 2. The case of non-independence: Heterologous associations. Eur J Biochem 187: 493-500, 1990
20. Kholodenko BN, Lyubarev AK, Kurganov BI: Control of metabolic flux in a system with high enzyme concentrations and moietyconserved cycles. The sum of the flux control coefficients can drop significantly below unity. Eur J Biochem 210: 147-153, 1992
21. Kholodenko BN, Westerhoff HV: Metabolic channelling and control of the flux. FEBS Lett 320: 71-74, 1993
22. Kholodenko BN, Cascante M, Westerhoff HV: Control and regulation of channelled versus ideal pathways. In: L Agius, HSA Sherratt (eds). Channelling in Intermediary Metabolism. Portland Press, London, 1997, pp 91-114
23. Kholodenko BN, Sauro HM, Westerhoff HV: Control by enzymes, coenzymes and conserved moieties: A generalization of the connectivity theorem of metabolic control analysis. Eur J Biochem 225: 179-186, 1994
24. Sauro HM: Moiety-conserved cycles and metabolic control analysis: Problems in sequestration and metabolic channelling. BioSystems 33: 55-67, 1994
25. Cori CF, Velick SF, Cori GT: Combination of diphosphopyridine nucleotide with glyceraldehyde phosphate debydrogenase. Biochim Biophys Acta 4: 160-169, 1950
26. Friedrich P: Dynamic compartmentation in soluble enzyme systems. Acta Biochim Biophys Acad Sci Hung 9: 159-173, 1974
27. Srivastava DK, Bernhard SA: Biophysical chemistry of metabolic reaction sequences in concentrated enzyme solution and in the cell. Annu Rev Biophys Biophys Chem 16: 175-204, 1987
28. Ushiroyama T, Fukushima T, Styre JD, Spivey HO: Substrate channelling of NADH in mitochondrial redox processes. Curr Top Cell Regul 33: 291-307, 1992
29. Kholodenko BN, Demin OV, Westerhoff HV: Channelled pathways can be more sensitive to specific regulatory signals. FEBS Lett 320: 75-78, 1993
30. Kholodenko BN, Cascante M, Westerhoff HV: Dramatic changes in control properties that accompany channelling and metabolite sequestration. FEBS Lett 336: 381-384, 1993
31. Kholodenko BN, Westerhoff HV, Puigjaner J, Cascante M: Control in channelled pathways. A matrix method calculating the enzyme control coefficients. Biophys Chem 53: 247-258, 1995
32. Kholodenko BN, Westerhoff HV, Brown GC: Rate limitation within a single enzyme is directly related to enzyme intermediate levels. FEBS Lett 349: 131-134, 1994
33. Brown GC, Westerhoff HV, Kholodenko BN: Molecular control analysis. Control within proteins and molecular processes. J Theor Biol 182:389-396, 1996
34. Brown GC, Cooper CE: Control analysis applied to single enzymes: Can an isolated enzyme have a unique rate-limiting step? Biochem J 294: 87-94, 1993
35. Kholodenko BN, Westerhoff HV: Control theory of one enzyme. Biochim Biophys Acta 1208: 294-305, 1994
36. Van Dam K, Van der Vlag J, Kholodenko BN, Westerhoff HV: The sum of the flux control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two. Eur J Biochem 212: 791-799, 1993
37. Kholodenko BN, Westerhoff HV: Control theory of group-transfer pathways. Biochim Biophys Acta 1229: 256-274, 1995
38. Kholodenko BN, Westerhoff HV: How to reveal various aspects of regulation in group-transfer pathways. Biochim Biophys Acta 1229: 275-289, 1995
39. Westerhoff HV, Van Dam K: Thermodynamics and Control of Biological Free Energy Transduction. Elsevier, Amsterdam, 1987
40. Kholodenko BN: Control of molecular transformations in multienzyme systems: quantitative theory of metabolic regulation. Mol Biol (USSR) 22: 1238-1256, 1988. Engl transl 22: 990-1005, 1989
41. Giersch C: Control analysis of metabolic networks. Homogeneous functions and the summation theorems for control coefficients. Eur J Biochem 174: 509-513, 1988
42. Kholodenko BN: Modern Theory of Metabolic Control. Viniti Press, Moscow (in Russian), 1991
43. Garner MM, Burg MB: Macromolecular crowding and confinement in cells exposed to hypertonicity. Am J Physiol 266: C877-C892, 1994
44. Adair G: A theory of partial osmotic pressure and membrane equilibria with special reference to application of Dalton's Law to hemoglobine solutions in the presence of salts. Proc R Soc Lond A120: 573-603, 1928
45. Brand MD, Vallis, BPS, Kesseler A: The sum of the flux control coefficients in the electron-transport chain of mitochondria. Eur J Biochem 226: 819-829, 1994
46. Kholodenko BN, Westerhoff HV, Cascante M: Channelling and the concentration of bulk phase intermediates as cytosolic proteins get more concentrated. Biochem J 313: 921-926, 1996
47. Mendes P, Kell DB, Westerhoff HV: Channelling can decrease pool size. Eur J Biochem 204: 257-266, 1992
48. Mendes P, Kell DB, Westerhoff HV: Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel. Biochim Biophys Acta 1289: 175-186, 1996
49. Easterby JS: A generalized theory of the transition time for sequential enzyme reactions. Biochem J 199: 155-161, 1981
50. Melendez-Hevia E, Torres NV, Sicilia J, Kacser H: Control analysis of transition times in metabolic systems. Biochem J 265: 195-202, 1990.
51. Easterby JS: Temporal analysis of the transition between steady states. In: A Cornish-Bowden and ML Cardenas (eds). Control of Metabolic Processes. Plenum Press, New York, 1990, pp 281-290
52. Cascante M, Melendez-Hevia E, Kholodenko BN, Sicilia J, Kacser H: Control analysis of transit time for free and enzyme-bound metabolites. Biochem J 308: 895-899, 1995
53. Kholodenko BN, Cascante M, Westerhoff HV: (1995b) Control theory of metabolic channelling. Mol Cell Biochem 143: 151-168, 1995
54. Snoep JL, Yomana LP, Westerhoff HV, Ingram LO: Protein burden in Zymomonas mobilis: Negative flux and growth control due to overproduction of glycolytic enzymes. Microbiology 141:2329-2337, 1995
55. Rohwer JM: Interaction of functional units of metabolism. Control and regulation of the bacterial phoshoenolpyruvate-dependent phosphotransferase system. Ph.D. thesis, University of Amsterdam, 1997