Reducing the dose of gonadotrophin-releasing hormone agonist on starting ovarian stimulation: Effect on ovarian response and in-vitro fertilization outcome

Human Reproduction

Volumn 13, Issue 9, 1998, Pages 2382-2385

  Elgendy, Manal ^a   Afnan, Masoud ^a   Holder, Roger ^a   Lashen, Hany ^a   Afifi, Yousri ^a   Lenton, William ^a   Sharif, Khaldoun ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

GnRHa; IVF; Nafarelin acetate; Ovarian stimulation; Reduced dose

Indexed keywords

CHORIONIC GONADOTROPIN; ESTRADIOL; GONADORELIN; GONADORELIN AGONIST; LUTEINIZING HORMONE; NAFARELIN ACETATE; PROGESTERONE; UROFOLLITROPIN;

ADULT; ARTICLE; BODY MASS; CLINICAL TRIAL; EMBRYO TRANSFER; ESTRADIOL BLOOD LEVEL; FEMALE; FERTILIZATION IN VITRO; HUMAN; INTRANASAL DRUG ADMINISTRATION; LUTEAL PHASE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; OOCYTE; OVARY STIMULATION; PROGESTERONE BLOOD LEVEL; TREATMENT OUTCOME;

EID: 0031705730     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/13.9.2382     Document Type: Article

References (28)

1. Alvarez, C. Cremades, N., Blasco, N. and Bernaben, R. (1997) Influence of gonadotrophin-releasing hormone agonist total dose in the ovarian stimulation in the long down-regulation protocol for in-vitro fertilization. Hum. Reprod., 12, 2366-2369.
2. Balasch, J., Gomez, F., Casamitjana, R. et al. (1992) Pituitary-ovarian suppression by the standard and half doses of D-Trp-6-LHRH depot. Hum. Reprod., 9, 1813-1817.
3. Broekmans, F., Hompes, P., Lambalk, C. et al. (1996) Short term pituitary desensitization, effects of different doses of the GnRHa, Triptorelin. Hum. Reprod., 11, 55-60.
4. Calhaz-Jorge, C., Leal, F., Cordeiro, I. et al. (1995) Pituitary down-regulation in IVF cycles, is it necessary to use strict criteria. IX World Congress on IVF and Alternated Assisted Reproduction. Vienna. Austria. April, 1995.
5. Corson, S., Eisenberg, E., Batzer, F., et al. (1992) Leuprolide acetate-prepared IVF/GIFT cycles: efficacy versus controls and cost analysis. Fertil. Steril., 57, 601-605.
6. Edwards, R.G., Lobo, R.A., Bouchard, P. (1997) Why delay the obvious need for milder forms of ovarian stimulation? Hum. Reprod., 12, 399-401.
7. FIVNAT (1996) 1995 French in-vitro national evaluation. Contracept. Fertil. Sex., 24, 694-699.
8. Furger, C., Bourrie N., Cedard, L., et al. (1996) GnRH and triptorelin inhibit the FSH-induced response in human primary cultured granulosa-lutein cells. Mol. Hum. Reprod., 2, 259-264.
9. Gougeon, A., Lefevre, B., Testart, J. (1992) Influence of a GnRHa and gonadotropins on morphometric characteristics of the population of small ovarian follicles in cynomolgus monkey (Macaca fascicularis). J. Reprod. Fertil., 95, 567-575.
10. Hazout, A., de Ziegler, D., Cornel, C. et al. (1993) Comparison of short 7-day and prolonged treatment with GnRHa desensitization for COH. Fertil. Steril., 59, 596-600.
11. Hillensjo, T. and LeMaire, W. (1980) GnRHa stimulate meiotic maturation of follicle-enclosed rat oocytes in vitro. Nature, 287, 145.
12. Hughes, E., Fedorkow, D., Daya, S. et al. (1992) The routine use of GnRHa prior to IVF and GIFT, a meta-analysis of randomized controlled trials. Fertil. Steril., 58, 888-896.
13. Koos, R. and LeMaire, W. (1985) The effects of a GnRHa on ovulation and steroidogenesis during perfusion of rabbit and rat ovaries in vitro. Endocrinology, 116, 628.
14. Latouche, J., Coumeyrolle-Arias, M., Jordan, D. et al. (1989) GnRH receptors in human granulosa cells, anatomical localization and characterization by autoradiographic study. Endocrinology, 125, 1739-1741.
15. Lockwood, G., Pinkerton, M., and Barlow, D. (1995) A prospective randomized single-blind comparative trial of nafarelin acetate with buserelin in long-protocol GnRHa controlled in IVF cycles. Hum. Reprod., 10, 293-298.
16. Maroulis, G., Emery, M., Verkauf, B. et al. (1991) Prospective randomized study of human menotropin versus follicular and luteal phase GnRHa/human menotropin stimulation protocols for IVF. Fertil. Steril., 55, 1126-1131.
17. Muasher, S.J. (1988) Stimulation protocols for patients with 'atypical response'. Ann. N. Y. Acad. Sci., 541, 82.
18. Pantos, K., Damianaki, T., Vaxevanoglou, T. et al. (1994) Prospective study of a modified GnRHa long protocol in an IVF program. Fertil. Steril., 61, 709-713.
19. Porcu, E., Prato, L., Seracchioli, R. et al. (1994) Comparison between depot and standard release triptoreline in IVF: pituitary sensitivity, luteal function, pregnancy outcome, and perinatal results. Fertil. Steril., 62, 126-132.
20. Rutherford, A., Subak-Sharp, R., Dawson, K. et al. (1988) Improvement of IVF after treatment with buserelin, an agonist of LHRH. Br. Med. J., 296, 1765-1768.
21. Shoham, Z., Jacobs, H. and Insler, V. (1993) LH: its role, mechanism of action, and detrimental effects when hypersecreted during the follicular phase. Fertil. Steril., 59, 1153-1161.
22. Simon, A., Benshushan, A., Shushan, A. et al. (1994) A comparison between a standard and reduced dose of D-Trp-6-LHRH administered after pituitary suppression for IVF. Hum. Reprod., 9, 1813-1817.
23. Smitz, J., Ron-El, R. and Tarlatzis, B. (1992) The use of GnRHa for IVF and other assisted procreation techniques: experience from three centres. Hum. Reprod. 7 (Suppl.), 49-63.
24. Strohmer, H., Chatwani, S., Wieser, F. et al. (1997) Prospective randomized study of an ultrashort gonadotrophin-releasing hormone agonist versus a modifed suppression protocol for ovarian stimulation in intracytoplasmic sperm injection cycles. Hum. Reprod., 12, 1403-1408.
25. Testart, J., Forman, R., Belaisch-Allart, J. et al. (1989) Embryo quality and uterine receptivity in IVF cycles with or without GnRHa. Hum. Reprod., 4, 198-201.
26. Tummon, I., Daniel, S., Kaplan, B. et al. (1992) Randomized prospective comparison of luteal leuprolide acetate and gonadotropins versus clomiphine citrate and gonadotropins in 408 first cycles of IVF. Fertil. Steril., 58, 563-568.
27. Wikland, M., Borg, J., Hamberger, L. et al. (1994) Simplification of IVF: minimal monitoring and the use of subcutaneous highly purified FSH administration for ovulation induction. Hum. Reprod., 9, 1430-1436.
28. 9-Net)-LH-RH factor inhibits follicular development in hypophysectomized rats. Nature, 280, 593.