Partition of thorium between organs of monkeys injected with thorotrast: Implications for alpha-particle dosimetry

Radiation Research

Volumn 150, Issue 3, 1998, Pages 369-372

  Ishikawa, Yuichi ^a,b   Humphreys, James A H ^b   Wesch, Horst ^c   Priest, Nicholas D ^b,d  

^a CANCER INSTITUTE   (Japan)

^b RICARDO UK LTD   (United Kingdom)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d MIDDLESEX UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

THORIUM 232; THORIUM DIOXIDE;

ALPHA RADIATION; ARTICLE; BONE MARROW; LIVER; MONKEY; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; SPLEEN; TESTIS; TISSUE DIFFERENTIATION;

EID: 0031705378     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579986     Document Type: Article

References (20)

1. G. van Kaick, H. Wesch, H. Luehrs, D. Liebermann and A. Kaul, Epidemiological results and dosimetric calculations - an update of the German Thorotrast study. In Health Effects of Internally Deposited Radionuclides: Emphasis on Radium and Thorium (G. van Kaick, A. Karaoglou and A. M. Kellerer, Eds.), pp. 171-175. EUR 15877 EN, World Scientific, Singapore, 1995.
2. T. Mori, K. Fukutomi, Y. Kato, Y. Akita, S. Hatakeyama, R. Machinami, H. Tanooka, H. Matsudaira, T. Maruyama and T. Kumatori, Recent results in the first series of the Japanese follow-up study of Thorotrast patients and their relationships with statistical analysis of autopsy series. In Health Effects of Internally Deposited Radionuclides: Emphasis on Radium and Thorium (G. van Kaick, A. Karaoglou and A. M. Kellerer, Eds.), pp. 181-191. EUR 15877 EN, World Scientific, Singapore, 1995.
3. M. Andersson, B. Carstensen and H. H. Storm, Mortality and cancer incidence after cerebral arteriography with or without Thorotrast. Radiat. Res. 142, 305-320 (1995).
4. Y. Ishikawa, T. Mori and R. Machinami, Lack of apparent excess of malignant mesothelioma but increased overall malignancies of peritoneal cavity in Japanese autopsies with Thorotrast injection into blood vessels. J. Cancer Res. Clin. Oncol. 121, 567-570 (1995).
5. M. Andersson, B. Carstensen and J. Visfeldt, Leukemia and other related hematological disorders among Danish patients exposed to Thorotrast. Radiat. Res. 134, 224-233 (1993).
6. A. Kaul and W. Noffz, Tissue dose in Thorotrast patients. Health Phys. 35, 113-121 (1978).
7. Y. Ishikawa, Y. Kato, T. Mori, R. Machinami and T. Kitagawa, Alpha-particle dose to the liver and spleen tissues of Japanese Thorotrast patients. Health Phys. 65, 497-506 (1993).
8. 228Ra in soft tissues and bones of a deceased Thorotrast patient. Health Phys. 63, 54-71 (1992).
9. J. J. Russell, R. L. Kathren, R. A. Short and J. F. McInroy, Long-term organ retention and pathology in a Thorotrast patient: A preliminary report. In Health Effects of Internally Deposited Radionuclides: Emphasis on Radium and Thorium (G. van Kaick, A. Karaoglou and A. M. Kellerer, Eds.), pp. 215-223. EUR 15877 EN, World Scientific, Singapore, 1995.
10. Y. Ishikawa, Y. Kato and S. Hatakeyama, Late effects of alpha-particles on Thorotrast patients. In Risks from Radium and Thorotrast (D. M. Taylor, C. W. Mays, G. B. Gerber and R. G. Thomas, Eds.), pp. 129-131. Report 21, British Institute of Radiology, London, 1989.
11. R. L. Kathren and R. L. Hill, Distribution and dosimetry of Thorotrast in USUR Case 1001. Health Phys. 63, 72-88 (1992).
12. Y. Ishikawa, J. A. H. Humphreys, N. D. Priest, T. Mori and Y. Kato, Thorium deposition in the bone marrow of Thorotrast patients. In Health Effects of Internally Deposited Radionuclides: Emphasis on Radium and Thorium (G. van Kaick, A. Karaoglou and A. M. Kellerer, Eds.), pp. 81-85. EUR 15877 EN, World Scientific, Singapore, 1995.
13. A. Kaul, Biokinetic models and data. In Health Effects of Internally Deposited Radionuclides: Emphasis on Radium and Thorium (G. van Kaick, A. Karaoglou and A. M. Kellerer, Eds.), pp. 53-67. EUR 15877 EN, World Scientific, Singapore, 1995.
14. N. D. Priest, J. A. H. Humphreys and Y. Ishikawa, The distribution of Thorotrast in the bone marrow: A study using human and monkey tissues. In Health Effects of Internally Deposited Radionuclides: Emphasis on Radium and Thorium (G. van Kaick, A. Karaoglou and A. M. Kellerer, Eds.), pp. 69-74. EUR 15877 EN, World Scientific, Singapore, 1995.
15. J. A. H. Humphreys, N. D. Priest and Y. Ishikawa, Thorotrast distribution in monkey bone marrow at early and late times after injection. Health Phys. 74, 442-447 (1998).
16. H. Wesch, H. Kampmann and K. Wegener, Assessment of organ distribution of thorium by neutron-activation-analysis. In Proceedings of the Third International Meeting on the Toxicity of Thorotrast (M. Faber, Ed.), pp. 52-60. Report No. 294, Danish Atomic Energy Commission Research Establishment Risø, Roskilde, 1973.
17. Y. Ishikawa, T. Mori, Y. Kato, R. Machinami, N. D. Priest and T. Kitagawa, Systemic deposits of thorium in Thorotrast patients with particular reference to sites of minor storage. Radiat. Res. 135, 244-248 (1993).
18. J. A. H. Humphreys, N. D. Priest, Y. Ishikawa, K. M. S. Townsend and J. F. McInroy, Studies of the distribution of Thorotrast in bone. In Health Effects of Internally Deposited Radionuclides: Emphasis on Radium and Thorium (G. van Kaick, A. Karaoglou and A. M. Kellerer, Eds.), pp. 75-79. EUR 15877 EN, World Scientific, Singapore, 1995.
19. J. D. Boice, Jr., Leukemia risk in Thorotrast patients. Radiat. Res. 136, 301-302 (1993).
20. L. G. Littlefield, L. B. Travis, A. M. Sayer, G. L. Voelz, R. H. Jensen and J. D. Boice, Jr., Cumulative genetic damage in hematopoietic stem cells in a patient with a 40-year exposure to alpha particles emitted by thorium dioxide. Radiat. Res. 148, 135-144 (1997).