Can we explain RNA-mediated virus resistance by homology-dependent gene silencing?

Molecular Plant-Microbe Interactions

Volumn 11, Issue 7, 1998, Pages 717-723

  Van Den Boogaart, Tom ^a   Lomonossoff, George P ^a   Davies, Jeffrey W ^a  

^a JOHN INNES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HOST RESISTANCE; RNA; TRANSGENE; VIRAL GENETICS;

EID: 0031698222     PISSN: 08940282     EISSN: None     Source Type: Journal    
DOI: 10.1094/MPMI.1998.11.7.717     Document Type: Review

References (66)

1. Andersen, J. M., Palukaitis, P., and Zaitlin, M. 1992. A defective replicase gene induces resistance to cucumber mosaic virus in transgenic tobacco plants. Proc. Natl. Acad. Sci. USA 89:8759-8763.
2. Angell, S. M., and Baulcombe, D. C. 1997. Consistent gene silencing in transgenic plants expressing a replicating potato virus X RNA. EMBO J. 16:3675-3684.
3. Baulcombe, D. C. 1996. Mechanisms of pathogen-derived resistance to viruses in transgenic plants. Plant Cell 8:1833-1844.
4. Baulcombe, D. C., and English, J. J. 1996. Ectopic pairing of homologous DNA and post-transcriptional gene silencing in transgenic plants. Curr. Opin. Biotechnol. 7:173-180.
5. Brederode, F. T., Taschner, P. E. M., Posthumus, E., and Bol, J. F. 1995. Replicase-mediated resistance to alfalfa mosaic virus. Virology 207:467-474.
6. Carr, J. P., Gal-On, A., Palukaitis, P., and Zaitlin, M. 1994. Replicase-mediated resistance to cucumber mosaic virus in transgenic plants involves suppression of both replication in the inoculated leaves and long-distance movement. Virology 199:439-447.
7. Carr, J. P., Marsh, L. E., Lomonossoff, G. P., Sekiya, M. E., and Zaitlin, M. 1992. Resistance to tobacco mosaic virus induced by the 54-kDa gene sequence requires expression of the 54-kDa protein. Mol. Plant-Microbe Interact. 5:397-404.
8. Covey, S. N., Al-Kaff, N. S., Lángara, A., and Turner, D. S. 1997. Plants combat infection by gene silencing. Nature 385:781-782.
9. de Haan, P., Gielen, J. J. L., Prins, M., Wijkamp, I. G., van Schepen, A., Peters, D., van Grinsven, M. Q. J. M., and Goldbach, R. 1992. Characterization of RNA-mediated resistance to tomato spotted wilt virus in transgenic tobacco plants. Bio/Technology 10:1133-1137.
10. Dehio, C., and Schell, J. 1994. Identification of plant genetic loci involved in a posttranscriptional mechanism for meiotically reversible transgene silencing. Proc. Natl. Acad. Sci. USA 91:5538-5542.
11. Dougherty, W. G., Lindbo, J. A., Smith, H. A., Parks, T. D., Swaney, S., and Proebsting, W. M. 1994. RNA-mediated virus resistance in transgenic plants: Exploitation of a cellular pathway possibly involved in RNA degradation. Mol. Plant-Microbe Interact. 7:544-552.
12. Dougherty, W. G., and Parks, T. D. 1995. Transgenes and gene suppression: Telling us something new? Curr. Opin. Cell Biol. 7:399-405.
13. Elmayan, T., and Vaucheret, H. 1996. Expression of single copies of a strongly expressed 35S transgene can be silenced post-transcriptionally. Plant J. 9:787-797.
14. English, J. J., Mueller, E., and Baulcombe, D. C. 1996. Suppression of virus accumulation in transgenic plants exhibiting silencing of nuclear genes. Plant Cell 8:179-188.
15. Finnegan, J., and McElroy, D. 1994. Transgene inactivation: Plants fight back! Bio/Technology 12:883-888.
16. Fraenkel-Conrat, H. 1986. RNA directed RNA polymerases of plants. Crit. Rev. Plant Sci. USA 4:213-226.
17. Frischmuth, T., and Stanley, J. 1993. Strategies for the control of geminivirus diseases. Semin. Virol. 4:329-337.
18. Golemboski, D. B., Lomonossoff, G. P., and Zaitlin, M. 1990. Plants transformed with a tobacco mosaic virus nonstructural gene sequence are resistant to the virus. Proc. Natl. Acad. Sci. USA 87:6311-6315.
19. Goodwin, J., Chapman, K., Swaney, S., Parks, T. D., Wernsman, E. A., and Dougherty, W. G. 1996. Genetic and biochemical dissection of transgenic RNA-mediated virus resistance. Plant Cell 8:95-105.
20. Hawkins, J. W., and Nellen, W. 1994. Mechanisms of antisense-mediated gene silencing. Antisense Res. Dev. 4:127-129.
21. Hellwald, K.-H., and Palukaitis, P. 1995. Viral RNA as a potential target for two independent mechanisms of replicase-mediated resistance against cucumber mosaic virus. Cell 83:937-946.
22. Hobbs, S. L. A., Kpodar, P., and DeLong, C. M. O. 1990. The effect of T-DNA copy number, position and methylation on reporter gene expression in tobacco transformants. Plant Mol. Biol. 15:851-864.
23. Hull, R. 1994. Resistance to plant viruses: Obtaining genes by non-conventional approaches. Euphytica 75:195-205.
24. Jorgensen, R. 1992. Silencing of plant genes by homologous transgenes. AgBiotech News Inform. 4:265-273.
25. Kumagai, M. H., Donson, J., Della-Cioppa, G., Harvey, D., Hanley, K., and Grill, L. K. 1995. Cytoplasmic inhibition of carotenoid biosynthesis with virus-derived RNA. Proc. Natl. Acad. Sci. USA 92:1679-1683.
26. Lapidot, M., Gafny, R., Ding, B., Wolf, S., Lucas, W. J., and Beachy, R. N. 1993. A dysfunctional movement protein of tobacco mosaic virus that partially modifies the plasmodesmata and limits virus spread in transgenic plants. Plant J. 4:959-970.
27. Lindbo, J. A., and Dougherty, W. G. 1992. Untranslatable transcripts of the tobacco etch virus coat protein gene sequence can interfere with tobacco etch virus replication in transgenic plants and protoplasts. Virology 189:725-733.
28. Lindbo, J. A., Silva-Rosales, L., Proebsting, W. M., and Dougherty, W. G. 1993. Induction of a highly specific antiviral state in transgenic plants: Implications for regulation of gene expression and virus resistance. Plant Cell 5:1749-1759.
29. Lomonossoff, G. P. 1995. Pathogen-derived resistance to plant viruses. Annu. Rev. Phytopathol. 33:323-343.
30. Longstaff, M., Brigneti, G., Boccard, F., Chapman, S., and Baulcombe, D. 1993. Extreme resistance to potato virus X infection in plants expressing a modified component of the putative viral replicase. EMBO J. 12:379-386.
31. Matzke, M. A., and Matzke, A. J. M. 1995. How and why do plants inactivate homologous (trans)genes? Plant Physiol. 107:679-685.
32. Meins, F., Jr., and Kunz, C. 1994. Gene silencing in transgenic plants: A heuristic autoregulation model. Curr. Top. Immunol. Microbiol. 197: 105-120.
33. Metzlaff, M., O'Dell, M., Cluster, P. D., and Flavell, R. B. 1997. RNA-mediated RNA degradation and chalcone synthase A silencing in Petunia. Cell 88:845-854.
34. Meyer, P., Linn, F., Heidmann, I., Meyer, H., Niedenhof, I., and Saedler, H. 1992. Endogenous and environmental factors influence 35S promotor methylation of a maize AI gene construct in transgenic Petunia and its colour phenotype. Mol. Gen. Genet. 231:345-352.
35. Meyer, P., and Saedler, H. 1996. Homology-dependent gene silencing in plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 47:23-48.
36. Mueller, E., Gilbert, J., Davenport, G., Brigneti, G., and Baulcombe, D. C. 1995. Homology-dependent resistance: Transgenic virus resistance in plants related to homology-dependent gene silencing. Plant J. 7: 1001-1013.
37. Napoli, C., Lemieux, C., and Jorgensen, R. 1990. Introduction of a chimeric chalcone synthase gene into Petunia results in reversible cosuppression of homologous genes in trans. Plant Cell 2:279-289.
38. Nguyen, L., Lucas, W. J., Ding, B., and Zaitlin, M. 1996. Viral RNA trafficking is inhibited in replicase-mediated resistant transgenic tobacco plants. Proc. Natl. Acad. Sci. USA 93:12643-12647.
39. Niebel, F. d. C., Frendo, P., van Montagu, M., and Cornelissen, M. 1995. Post-transcriptional cosuppression of β-1,3-glucanase genes does not affect accumulation of transgene nuclear mRNA. Plant Cell 7:346-358.
40. Palauqui, J.-C., Elmayan, T., Pollien, J.-M., and Vaucheret, J. 1997. Systemic acquired silencing: Transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions. EMBO J. 16:4738-4745.
41. Palukaitis, P., and Zaitlin, M. 1997. Replicase-mediated resistance to plant virus disease. Adv. Virus Res.48:349-377.
42. Pang, S.-Z., Bock, J. H., Gonsalves, C., Slightom, J. L., and Gonsalves, D. 1994. Resistance of transgenic Nicotiana benthamiana plants to tomato spotted wilt and impatiens necrotic spot tospovirus: Evidence of involvement of the N protein and N gene RNA in resistance. Phytopathology 84:243-249.
43. Pang, S.-Z., Jan, F.-J., Carney, K., Stout, J., Tricoli, D. M., Quemada, H. D., and Gonsalves, D. 1996. Post-transcriptional transgene silencing and consequent tospovirus resistance in transgenic lettuce are affected by transgene dosage and plant development. Plant J. 9:899-909.
44. Pang, S.-Z., Jan, F.-J., and Gonsalves, D. 1997. Nontarget DNA sequences reduce the transgene length necessary for RNA-mediated tospovirus resistance in transgenic plants. Proc. Natl. Acad. Sci. USA 94:8261-8266.
45. Pappu, H. R., Niblett, C. L., and Lee, R. F. 1995. Application of recombinant DNA technology to plant protection: Molecular approaches to engineering virus resistance in crop plants. World J. Microbiol. Biotechnol. 11:426-437.
46. Powell-Abel, P., Nelson, R. S., De, B., Hoffmann, N., Rogers, S. G., Fraley, R. T., and Beachy, R. N. 1986. Delay of disease development in transgenic plants that express the tobacco mosaic virus coat protein gene. Science 232:738-743.
47. Prins, M., de Haan, P., Luyten, R., van Veller, M., van Grinsven, M. Q. J. M., and Goldbach, R. 1995. Broad resistance to tospoviruses in transgenic tobacco plants expressing three tospoviral nucleoprotein gene sequences. Mol. Plant-Microbe Interact. 8:85-91.
48. Prins, M., de Oliveira Resende, R., Anker, C., van Schepen, A., de Haan, P., and Goldbach, R. 1996. Engineered RNA-mediated resistance to tomato spotted wilt virus is sequence specific. Mol. Plant-Microbe Interact. 9:416-418.
49. Prins, M., and Goldbach, R. 1996. RNA-mediated virus resistance in transgenic plants. Arch. Virol. 141:2259-2276.
50. M gene sequences. Plant Mol. Biol. 33:235-243.
51. Que, Q., Wang, H.-Y., English, J. J., and Jorgensen, R. A. 1997. The frequency and degree of cosuppression by sense chalcone synthase transgenes are dependent on transgene promotor strength and are reduced by premature nonsense codons in the transgene coding sequence. Plant Cell 9:1357-1368.
52. Ratcliff, F., Harrison, B. D., and Baulcombe, D. C. 1997. A similarity between viral defense and gene silencing in plants. Science 276:1558-1560.
53. Sanford, J. C., and Johnston, S. A. 1985. The concept of parasite-derived resistance-deriving resistance genes from the parasite's own genome. J. Theor. Biol. 113:395-405.
54. Sijen, T., Wellink, J., Hiriart, J. B., and van Kammen, A. 1996. RNA-mediated virus resistance: Role of repeated transgenes and delineation of targeted regions. Plant Cell 8:2277-2294.
55. Smith, H. A., Swaney, S. L., Parks, T. D., Wernsman, E. A., and Dougherty, W. G. 1994. Transgenic plant virus resistance mediated by untranslatable sense RNAs: Expression, regulation and fate of nonessential RNAs. Plant Cell 6:1441-1453.
56. Stam, M., Bruin, R. d., Kenter, S., Hoorn, R. A. L. v. d., Blokland, R. v., Mol, J. N. M., and Kooter, J. M. 1997a. Post-transcriptional silencing of chalcone synthase in Petunia by inverted transgene repeats. Plant J. 12:63-82.
57. Stam, M., Mol, J. N. M., and Kooter, J. M. 1997b. The silence of genes in transgenic plants. Ann. Bot. 79:3-12.
58. Swaney, S., Powers, H., Goodwin, J., Silva Rosales, L., and Dougherty, W. G. 1995. RNA-mediated resistance with nonstructural genes from the tobacco etch virus genome. Mol. Plant-Microbe Interact. 8:1004-1011.
59. Tanzer, M. M., Thompson, W. F., Law, M. D., Wernsman, E. A., and Uknes, S. 1997. Characterization of post-transcriptionally suppressed transgene expression that confers resistance to tobacco etch virus infection in tobacco. Plant Cell 9:1411-1423.
60. Vaira, A. M., Semeria, L., Crespi, S., Lisa, V., Allavena, A., and Accotto, G. P. 1995. Resistance to tospoviruses in Nicotiana benthamiana transformed with the N gene of tomato spotted wilt virus: Correlation between transgene expression and protection in primary transformants. Mol. Plant-Microbe Interact. 8:66-73.
61. van Blokland, R., van der Geest, N., Mol, J. N. M., and Kooter, J. I. I. 1994. Transgene-mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover. Plant J. 6:861-877.
62. van der Krol, A. R., Mur, L. A., Beld, M., Mol, J., and Stuitje, A. R. 1990. Flavonoid genes in petunia: Addition of a limited number of copies may lead to a suppression of gene expression. Plant Cell 2: 291-299.
63. N in tobacco plants transformed with the viral coat protein cistron. Plant Mol. Biol. 20:631-639.
64. van Kammen, A. 1997. Virus-induced gene silencing in infected and transgenic plants. Trends Plant Sci. 2:409-411.
65. Voinnet, O., and Baulcombe, D. C. 1997. Systemic signalling in gene silencing. Nature 389:553.
66. Wassenegger, M., Heimes, S., Riedel, L., and Sänger, H. L. 1994. RNA-directed de novo methylation of genomic sequences in plants. Cell 76:567-576.