Inhibition of malaria-infected erythrocytes by deoxyspergualin: Effect on in vitro growth of malarial cultures

Chemotherapy

Volumn 44, Issue 6, 1998, Pages 409-413

  Midorikawa, Yutaka ^a   Haque, Quazi Manjurul ^b   Nakazawa, Shusuke ^b  

^a SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b NONE

Author keywords

Deoxyspergualin; In vitro; Inhibition; Malaria

Indexed keywords

15 DEOXYSPERGUALIN; ANTIMALARIAL AGENT; HYPOXANTHINE; TRITIUM;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; ERYTHROCYTE; GROWTH; HUMAN; HUMAN CELL; MACROMOLECULE; MALARIA; NONHUMAN; PARASITE CULTIVATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALS; ANTIMALARIALS; CELLS, CULTURED; DNA, PROTOZOAN; ERYTHROCYTES; GUANIDINES; HUMANS; MALARIA, FALCIPARUM; MICE; MICE, INBRED BALB C; PLASMODIUM FALCIPARUM; TRITIUM;

EID: 0031698152     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007152     Document Type: Article

References (20)

1. Danzin C, Casara P: α-Allenyl putrescine, an enzyme-activated irreversible inhibitor of bacterial and mammalian ornithine decarboxylases. FEBS Lett 1984;174:275-278.
2. Iwasawa H, Kondo S, Ikeda D, Takeuchi T, Umezawa H: Synthesis of (-)-15-deoxyspergualin and (-)-spergualin-15-phosphate. J Antibiot 1982;35:1665-1669.
3. Nemoto K, Ito J, Abe F: Immunosuppressive activities of 15-deoxyspergualin, in animals. J Antibiot (Tokyo) 1987;40:561-562.
4. Hibasami H, Maekawa S, Murata T, Nakashima K: Antitumor effect of a new multienzyme inhibitor of the polyamine synthetic pathway, methylglyoxalbis(cyclopentylamidinohydra-zone) against human and mouse leukemia cells. Cancer Res 1989;49: 2065-2068.
5. Midorikawa Y, Hibasami H, Gasaluck P, Nakashima S, Imai M: Evaluation of the anti-microbial activity of methylglyoxal bis (guanyl hydrazone analogues), the inhibitors in the polyamine biosynthetic pathway. J Appl Bacteriol 1991;70:291-293.
6. Hibasami H, Midorikawa Y, Gasaluck P, Takaji S, Nakashima K, Imai M: Bactericidal effect of 15-deoxspergualin on Staphylococcus aureus. Chemotherapy 1991;37:202-205.
7. Hibasami H, Midorikawa Y, Gasaluck P, Tsukada T, Shirakawa S, Imai M: Growth inhibition of Candida by 15-deoxyspergualin, an immunosuppressive agent used in experimental organ transplantation. Lett Appl Microbiol 1992;14:81-83.
8. Midorikawa Y: Can polyamine inhibitors be anti-malarial drugs? (in Japanese). J Clin Exp Med 1993; 164:138.
9. Alan JB, Dumont TL, Buch JA, Edward ML, Stemerick DM, Macann P, Sjoerdsma A: Bis (benzyl) polyamine analogs inhibit the growth of chloroquine-resistant human malarial parasite (Plasmodium falciparum) in vitro and in combination with alfa-difluouromethylornithine cure murine malaria. Proc Natl Acad Sci USA 1989;86:651-655.
10. Gautama AS, Sharma RC, Bhatt RM, Gupta DK: Microscopic diagnosis of malaria in the Kehda district of Gujarat. Indian J Malariol 1992;29:83-87.
11. Division of control of tropical diseases, WHO: World malaria situation 1988. World Health Stat Q 1990;43:68-79.
12. Campbell CC: Challenges facing antimalarial therapy in Africa. J Infect Dis 1991;163:1207-1211.
13. Cattani JA, Tulloch JL, Vrbova H, Jolley D, Gibson FD, Moir JS, Heywood PF, Alpers MP, Stevenson A, Clancy R: The epidemiology of malaria in a population surrounding Madang, Papua New Guinia. Am J Trop Med Hyg 1986;35:3-15.
14. Midorikawa Y, Haque QM: Effect of deoxyspergualin on the growth of Plasmodium berghei in mice. Jpn J Trop Med Hyg 1996;24:5-9.
15. Midorikawa Y, Haque QM: 15-Deoxyspergualin, an immunosuppressive agent, used in organ transplantation, showed suppressive effects on malarial parasites. Chemotherapy 1997;43:31-35.
16. Suzuki S, Kanashiro M, Amemiya H: Effect of a new immuno-suppressant, 15-deoxyspergualin, on heterotopic rat heart transplantation in comparison with cyclosporine. Transplantation 1987;44:483-487.
17. Perlmann H, Berzins K, Wahlgren M, Carlsson J, Bjrokman A, Patarroyo ME, Perlmann P: Antibodies in malarial sera to parasite antigens in the membranes of erythrocytes infected with early asexual stages of Plasmodium falciparum. J Exp Med 1984;159:1686-1704.
18. Whaun JM, Broun NB: Ornithine decarboxylase inhibition and the malaria-infected red cell: A model for polyamine metabolism and growth. J Pharmacol Exp Ther 1985;233:597-611.
19. Hibasami H, Tsukada T, Suzuki R, Takano K, Takaji S, Tkeuchi T, Shirakawa S, Murata T, Nakashima K: 15-deoxispergualin, an antiproliferative agent for human and mouse leukemia cells shows inhibitory effects on the synthetic pathway of polyamines. Anticancer Res 1991; 11:325-330.
20. Tamura K, Nitami H, Ogawa M, Kimura K: Phase I and pharmacokinetic study of deoxyspergualin given by 3-hour infusion for 5 days (abstract). Proc Am Soc Clin Oncol 1989;8:74.