Constipation as an adverse effect of drug use in nursing home patients: An overestimated risk

British Journal of Clinical Pharmacology

Volumn 46, Issue 3, 1998, Pages 255-261

  Van Dijk, K N ^a,b,d   De Vries, C S ^a   Van Den Berg, P B ^a   Dijkema, A M ^a   Brouwers, J R B J ^a   De Jong van Den Berg, L T W ^a,c  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Wilhelmina Ziekenhuis   (Netherlands)

^c De Tjongerschans Hospital   (Netherlands)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Adverse effects; Cohort study; Constipation; Laxatives; Nursing home patients; Prescription sequence analysis

Indexed keywords

ANTIDEPRESSANT AGENT; ATROPINE; BIPERIDEN; BISACODYL; CALCIUM CHANNEL BLOCKING AGENT; CHLORPROMAZINE; CHLORPROTHIXENE; CLOMIPRAMINE; CLOZAPINE; CODEINE; DISOPYRAMIDE; DOCUSATE SODIUM; DOXEPIN; FLAVOXATE; IMIPRAMINE; LACTITOL; LAXATIVE; MAGNESIUM OXIDE; MAPROTILINE; MORPHINE; NICOMORPHINE; OPIATE; ORPHENADRINE; OXYPHENCYCLIMINE; PETHIDINE; SEROTONIN UPTAKE INHIBITOR; THIAZINAMIUM; THIORIDAZINE; UNINDEXED DRUG; VERAPAMIL;

AGED; ARTICLE; CASE CONTROL STUDY; COHORT ANALYSIS; CONSTIPATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; NURSING HOME; OUTCOMES RESEARCH; PRESCRIPTION; PRIORITY JOURNAL; RISK;

AGED; AGED, 80 AND OVER; CATHARTICS; COHORT STUDIES; CONSTIPATION; FEMALE; HOMES FOR THE AGED; HUMANS; MALE; NURSING HOMES; PHARMACEUTICAL PREPARATIONS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 0031695165     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1998.00777.x     Document Type: Article

References (22)

1. Monane M, Avorn J, Beers MH, Everitt DE. Anticholinergic drug use and bowel function in nursing home patients. Arch Intent Med 1993; 153: 633-638.
2. Stewart RB, Moore MT, Marks RG, Hale WE. Correlates of constipation in an ambulatory elderly population. Am J Gastroenterol 1992; 87: 859-864.
3. Talley NJ, Fleming KC, Evans JM, et al. Constipation in an elderly community: a study of prevalence and potential risk factors. AmJ Gastroenterol 1996; 1: 19-25.
4. Harari D, GurwitzJH, Avorn J, Choodnovskiy I, Minaker KL. Constipation: assessment and management in an institutionalized elderly population. J Am Geriatr Sac 1994; 42: 947-952.
5. Drouwers JRBJ, Tytgat G. Laxatives for elderly people with constipation. Formulary criteria, precautions and complications. Phann Wcekbl 1993; 128: 1483-1487.
6. Wald A. Constipation in elderly patients. Pathogenesis and management. Drugs Aging 1993; 3: 220-231.
7. Harari D, Gurwitz JH, Minaker KL. Constipation in the elderly. J Am Geriatr Soc 1993; 41: 1130-1140.
8. Feinberg M. The problems of anticholinergic adverse effects in older patients. Drugs Aging 1993; 3: 335-348.
9. Riedel WJ, Van Praag HM. Avoiding and managing anticholinergic effects of antidepressants. CNS Drugs 1995; 3: 245-259.
10. Jones RH, Tait CL. Gastrointestinal side-effects of NSAIDs in the community. BrJ Clin Pract 1995; 49: 67-70.
11. Harari D, Gurwits JH, Avom J, Choodnovskiy I, Minaker KL. Correlates of regular laxative use by frail elderly persons. AmJ Med 1995; 99: 513-518.
12. PetriJL, De Vet HCW, Naus J, Urquhart J. Prescription sequence analysis: a new and fast method for assessing certain adverse reactions of prescription drugs in large populations. Statis Med 1988; 7: 1171-1175.
13. Anonymous. Anatomical Tlierapeutic Clieinical (ATC) classification index. Oslo: WHO collaborating centre for drug statistics methodology 1994.
14. SIG. Informatics in Health and Welfare, Utrecht, The Netherlands.
15. Dutch Medicines Evaluation Board, Rijswijk, The Netherlands.
16. Iiifonnatoriiim Aledicamentoniin. Royal Dutch Society for the Advancement of Pharmacy, The Hague, The Netherlands 1994.
17. Meyler's side effects of dmgs. Twelfth edn, ed Dukes MNG, Amsterdam: Elsevier Science Publishers 1992.
18. Norusis MJSPSS. 6.1. Guide to data analysis. New Jersey: Prentice-Hall Inc. Englewood Cliffs.
19. Towers AL, Burgio KL, Locher JL, Merkel IS, Safaeian M, Wald A. Constipation in the elderly: influence of dietary, psychological, and physiological factors. J Am Gcriatr Sac 1994; 42: 701-706.
20. Mikus G, Trausch B, Rodewald C, et al. Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype. Clin Phannacol Tlier 1997; 61: 259-266.
21. Egberts ACG, Koning de GHP, Dakker A, Leufkens HGM. Adverse events associated with antidepressant drugs published in the medical literature. In Egberts ACG. Pharmacocpidetniologic approaches to the evaluation of antidepressaut drugs (thesis). Utrecht: Utrecht University 1997.
22. Egberts ACG, Leufkens HGM, Launer LJ, Grobbec DE, Hofman A, Hoes AW. Characteristics of older subjects using antidepressant drugs. In Egberts ACG. Pliannacoepidemiologic approaches to the evaluation of antidepressant drugs (thesis). Utrecht: Utrecht University 1997.