Efficacy of a bioreactor filled with porcine hepatocytes immobilized on nonwoven fabric for ex vivo direct hemoperfusion treatment of liver failure in pigs

Artificial Organs

Volumn 22, Issue 12, 1998, Pages 1031-1037

  Naruse, Katsutoshi ^a   Nagashima, Ikuo ^a   Sakai, Yasuyuki ^b   Harihara, Yasushi ^a   Jiang, Gao Xiao ^c   Suzuki, Motoyuki ^b   Muto, Tetsuichiro ^c   Makuuchi, Masatoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b INSTITUTE OF INDUSTRIAL SCIENCE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Direct hemoperfusion; Hybrid bioartificial liver; Liver failure model; Nonwoven fabric bioreactor; Porcine hepatocytes

Indexed keywords

BIOCONVERSION; BIOREACTORS; BLOOD; MAMMALS; NONWOVEN FABRICS; WEAVING;

BIOARTIFICIAL LIVER; DIRECT HEMOPERFUSION; FAILURE MODELLING; HEMOPERFUSION; HEPATOCYTES; HYBRID BIOARTIFICIAL LIVER; LIVER FAILURE; LIVER FAILURE MODEL; NONWOVEN FABRIC BIOREACTOR; PORCINE HEPATOCYTE;

ARTIFICIAL ORGANS;

POLYESTER; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL LIVER; BIOREACTOR; CONTROLLED STUDY; HEMOPERFUSION; IMMOBILIZED CELL; LIVER CELL; LIVER FAILURE; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0031695015     PISSN: 0160564X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1594.1998.06104.x     Document Type: Article

References (10)

1. Rozga J, Wiliams F, Ro MS, Demetriou AA. Development of bioartificial liver: Properties and function of a hollow-fiber module inoculated with liver cells. Hepatology 1992;17(2): 258-65.
2. Rozga J, Michael D, Holzman D, Ro MS, Griffin DW, Neuzil DF, Demetriou AA. Development of a hybrid bioartificial liver. Ann Surg 1993;217(5):502-11.
3. Sussmann NL, Chong MG, Koussayer T, He D, Shang TA, Whisennand HH, Kelly JH. Reversal of fulminant hepatic failure using an extracorporeal liver assist device. Hepatology 1992;16(1):60-5.
4. Sussmann NL, Gislason GT, Conlin CA, Kelly JH. The hepatic extracorporeal liver assist device: Initial clinical experience. Artif Organs 1994;18(5):390-6.
5. Nyberg SL, Shatford RA, Peshwa MV, White JG, Cerra FB, Hu WS. Evaluation of a hepatocyte-entrapment hollow fiber bioreactor. A potential bioartificial liver. Biotechnol Bioeng 1993;41:194-203.
6. Gerlach J, Jorres A, Troat O, Neuhaus P. Side effects of hybrid liver support therapy: TNF-α liberation in pigs associated with extracorporeal bioreactors. Int J Artif Organs 1993; 16:604-8.
7. Naruse K, Sakai Y, Nagashima I, Jiang GX, Suzuki M, Muto T. Development of a new bioartificial liver module filled with porcine hepatocytes immobilized on non-woven fabric. Int J Artif Organs 1996;19(6):347-52.
8. Naruse K, Sakai Y, Nagashima I, Jiang GX, Suzuki M, Muto T. Comparisons of porcine hepatocyte spheroids and single hepatocytes in the non-woven fabric bioartificial liver module. Int J Artif Organs 1996;19(10):605-9.
9. Sakai Y, Naruse K, Nagashima I, Muto T, Suzuki M. Large-scale preparation and function of porcine hepatocyte spheroids. Int J Artif Organs 1996;19(5):294-301.
10. Schiff L, Schiff ER. Diseases of the liver. 7th Edition. Vol. 1. Philadelphia: J. B. Lippincott, 1993.