Diminution of contractile response by κ-opioid receptor agonists in isolated rat ventricular cardiomyocytes is mediated via a pertussis toxin-sensitive G protein

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 358, Issue 3, 1998, Pages 360-366

  Wenzlaff, Holger ^a   Stein, Birgitt ^b   Teschemacher, Hansjörg ^a  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Cardiomyocytes; DADLE; Dynorphin U 50,488; G proteins; Naloxone; Nor binaltorphimine; Opioid receptors; Pertussis toxin

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; DYNORPHIN; DYNORPHIN A; DYNORPHIN[1-8]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN; KAPPA OPIATE RECEPTOR; NALOXONE; NORBINALTORPHIMINE; OPIATE AGONIST; OPIATE ANTAGONIST; PERTUSSIS TOXIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; HEART CELL CULTURE; HEART MUSCLE CONTRACTILITY; HYPOXIA; INOTROPISM; NONHUMAN; RAT;

EID: 0031694524     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005265     Document Type: Article

References (47)

1. 2-adenosine receptors on cardiomyocytes. J Pharmacol Exp Ther 254:1017-1023
2. Canossa M, Ventura C, Vaona I, Carboni L, Guarnieri C, Spampinato S (1993) Prodynorphin mRNA expression in adult cultured rat ventricular cardiac myocytes. Biochim Biophys Acta 1172:247-250
3. 2+- and species-dependent systolic and diastolic contractile properties of intact muscle. J Gen Physiol 88:589-613
4. Childers SR (1993) Opioid receptor-coupled second messenger systems. In: Herz A (ed) Opioid I (Handbook of experimental pharmacology series, vol 104). Springer, Berlin Heidelberg New York, pp 189-216
5. Clô C, Muscari C, Tantini B, Pignatti C, Bernardi P, Ventura C (1985) Reduced mechanical activity of perfused rat heart following morphine or enkephalin peptides administration. Life Sci 37:1327-1333
6. Cox BM (1993) Opioid receptor-G protein interactions: acute and chronic effects of opioids. In: Herz A (ed) Opioid I (Handbook of experimental pharmacology series, vol 104). Springer, Berlin Heidelberg New York, pp 145-188
7. Dhawan BN, Cesselin F, Raghubir R, Reisine T, Bradley PB, Portoghese PS, Hamon M (1996) International union of pharmacology. XII. Classification of opioid receptors. Pharmacol Rev 48:567-592
8. Dumont M, Roy D, Lemaire S (1997) Nonexocytotic noradrenaline release from rat cardiac synaptosomal-mitochondrial fractions. J Cardiovasc Pharmacol 30:302-308
9. 2+-transients and intracellular pH in cultured cardiac myocytes. J Mol Cell Cardiol 26:599-613
10. Ela C, Barg J, Vogel Z, Hasin Y, Eilam Y (1997) Distinct components of morphine effects on cardiac myocytes are mediated by the K and δ opioid receptors. J Mol Cell Cardiol 29:711-720
11. Faden AI (1993) Role of endogenous opioids in central cardiovascular regulation and dysregulation. In: Herz A (ed) Opioid II (Handbook of experimental pharmacology series, vol 104). Springer, Berlin Heidelberg New York, pp 191-204
12. Feuerstein G, Sirén A-L (1987) The opioid system in cardiac and vascular regulation of normal and hypertensive states. Circulation 75 [Suppl I]:I125-I129
13. Gautret B, Schmitt H (1985) Central and peripheral sites for cardiovascular actions of dynorphin-(1-13) in rats. Eur J Pharmacol 111:263-266
14. Goldberg AH, Padget CH (1969) Comparative effects of morphine and fentanyl on isolated heart muscle. Anesth Analg 48:978-982
15. Holaday JW (1983) Cardiovascular effects of endogenous opiate systems. Annu Rev Pharmacol Toxicol 23:541-594
16. Isenberg G, Klöckner U (1982) Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium". Pflügers Arch 395:6-18
17. 3H]U69593 binding sites in the rat heart. J Mol Cell Cardiol 27:1507-1511
18. Kasper E, Ventura C, Ziman BD, Lakatta EG, Weisman H, Capogrossi MC (1992) Effect of U-50,488H on the contractile response of cardiomyopathic hamster ventricular myocytes. Life Sci 50:2029-2035
19. Krumins SA (1987) Characterization of dermorphin binding to membranes of rat brain and heart. Neuropeptides 9:93-102
20. Krumins SA, Faden AI, Feuerstein G (1985) Opiate binding in rat hearts: Modulation of binding after hemorrhagic shock. Biochem Biophys Res Commun 127:120-128
21. Lee AYS, Wong TM (1987) Effects of dynorphin 1-13 on cardiac rhythm and cyclic adenosine monophosphate (cAMP) levels in the isolated perfused heart. Neurosci Lett 80:289-292
22. Mantelli L, Corti V, Ledda (1987) On the presence of opioid receptors in guinea-pig ventricular tissue. Gen Pharmacol 18:309-313
23. Meng F, Xie G-X, Thompson RC, Mansour A, Goldstein A, Watson SJ, Akil H (1993) Cloning and pharmacological characterization of a rat κ-opioid receptor. Proc Natl Acad Sci USA 90:9954-9958
24. Meng F, Hoversten MT, Thompson RC, Taylor L, Watson SJ, Akil H (1995) A chimeric study of the molecular basis of affinity and selectivity of the κ and the δ opioid receptors. J Biol Chem 270:12730-12736
25. Minami M, Satoh (1995) Molecular biology of the opioid receptors: structures, functions and distributions. Neurosci Res 23:121-145
26. Muraki T, Nomoto T, Kato R (1989) Developmental changes in the effects of carbachol and morphine on cGMP contents of plasma, heart, and lung of mice. Can J Physiol Pharmacol 67:1283-1287
27. Niroomand F, Mura RA, Piacentini L, Kübler W (1996) Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma. Naunyn Schiedeberg's Arch Pharmacol 354:643-649
28. Pepe S, Xiao R-P, Hohl C, Altschuld R, Lakatta EG (1997) 'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart. Circulation 95:2122-2129
29. i in myocytes. Am J Physiol 272:C560-C564
30. Smart D, Lambert DG (1996) The stimulatory effects of opioids and their possible role in the development of tolerance. Trends Pharmacol Sci 17:264-269
31. 3H]U69593 binding sites in the heart by receptor binding assays. J Mol Cell Cardiol 23:1297-1302
32. Tai KK, Bian CF, Wong TM (1992) κ-Opioid receptor stimulation increases intracellular free calcium in isolated rat ventricular myocytes. Life Sci 51:909-913
33. Utz J, Eckert R, Trautwein W (1995) Inhibition of L-type calcium currents in guinea pig ventricular myocytes by the κ-opioid agonist U50488H does not involve binding to opiate receptors. J Pharmacol Exp Ther 274:627-633
34. Ventura C, Pintus G (1997) Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster. III. Autocrine stimulation of prodynorphin gene expression by dynorphin B. J Biol Chem 272:6699-6705
35. Ventura C, Muscari C, Spampinato S, Bernardi P, Caldarera CM (1987) Effects of naloxone on the mechanical activity of isolated rat hearts perfused with morphine or opioid peptides. Peptides 8:695-699
36. Ventura C, Bastagli L, Bernardi P, Caldarera CM, Guarnieri C (1989) Opioid receptors in rat cardiac sarcolemma: effects of phenylephrine and isoproterenol. Biochim Biophys Acta 987:69-74
37. 2+ in cardiac myocytes. Am J Physiol 261:H1671-H1674
38. Ventura C, Lakatta EG, Sisini A, Campus MP, Capogrossi MC (1991b) Leucine-enkephalin increases the level of inositol (1,4,5) triphosphate and releases calcium from an intracellular pool in rat ventricular cardiac myocytes. Boll Soc Ital Biol Sper 67:261-266
39. 4 formation in adult cultured rat ventricular myocytes. Biochem Biophys Res Commun 179:972-978
40. 2+ release from an intracellular pool in myocytes and neurons. Circ Res 70:66-81
41. Ventura C, Guarnieri C, Vaona I, Campana G, Pintus G, Spampinato S (1994) Dynorphin gene expression and release in the myocardial cell. J Biol Chem 269:5384-5386
42. 2+ channel currents. J Mol Cell Cardiol 25:661-666
43. Xiao R-P, Pepe S, Spurgeon HA, Capogrossi MC, Lakatta EG (1997) Opioid peptide receptor stimulation reverses β-adrenergic effects in rat heart cells. Am J Physiol 272:H797-H805
44. Xue J-C, Chen C, Zhu J, Kunapuli S, DeRiel K, Yu L, Liu-Chen L-Y (1994) Differential binding domains of peptide and non-peptide ligands in the cloned rat κ-opioid receptor. J Biol Chem 269:30195-30199
45. Yamada K, Yoshida S, Shimada Y (1991) Atrial natriuretic polypeptide secretion via selective activation of κ-opioid receptor: role of dynorphin. Am J Physiol 261:E293-E297
46. Zhang WM, Wong TM (1998) Suppression of cAMP by phosphoinositol/Ca2+ pathway in the cardiac k opioid receptor. Am J Physiol 274: C82-C87
47. Zimlichman R, Gefel D, Eliahou H, Matas Z, Rosen B, Gass S, Ela C, Eilam Y, Vogel Z, Barg J (1996) Expression of opioid receptors during heart ontogeny in normotensive and hypertensive rats. Circulation 93:1020-1025