2-Phenyl-4-quinolone prevents serotonin-induced increases in endothelial permeability to albumin

European Journal of Pharmacology

Volumn 354, Issue 2-3, 1998, Pages 205-213

  Lee, Hong Zin ^a   Lin, Wen Chang ^b   Yeh, Feng Tsgh ^a   Wu, Chun Hsiung ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

2 Phenyl 4 quinolone; 5 HT (5 hydroxytryptamine, serotonin); Actin microfilament; Cytochalasin B; Endothelial cell, rat; Myosin; Permeability

Indexed keywords

ALBUMIN; BOVINE SERUM ALBUMIN; CYTOCHALASIN B; F ACTIN; MYOSIN; QUINOLONE DERIVATIVE; SEROTONIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM; ENDOTHELIUM CELL; HEART MUSCLE CELL; MACROMOLECULE; MICROFILAMENT; NONHUMAN; PRIORITY JOURNAL; RAT;

ACTINS; ANIMALS; CARDIOTONIC AGENTS; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CYCLIC AMP; CYTOCHALASIN B; CYTOSKELETON; ENDOTHELIUM, VASCULAR; HEART; MICROFILAMENTS; MYOSINS; QUINOLONES; RATS; SEROTONIN; SEROTONIN ANTAGONISTS; SERUM ALBUMIN;

EID: 0031694132     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00452-X     Document Type: Article

References (32)

1. Alexander, J.S., Hechtman, H.B., Shepro, D., 1988. Phalloidin enhances endothelial barrier function and reduces inflammatory permeability in vitro. Microvasc. Res. 35, 308-315.
2. Alexander, J.S., Blaschuk, O.W., Haselton, F.R., 1993. An N-cadherin-like protein contributes to solute barrier maintenance in cultured endothelium. J. Cell. Physiol. 156, 610-618.
3. Bensch, K.G., Davison, P.M., Karasek, M.A., 1983. Factors controlling the in vitro growth pattern of human microvascular endothelial cells. J. Ultrastruct. Res. 82, 76-89.
4. Garcia, J.G.N., Schaphorst, K.L., 1995. Regulation of endothelial cell gap formation and paracellular permeability. J. Invest. Med. 43, 117-126.
5. Garcia, J.G.N., Birnboim, A.S., Bizios, R., Del Vecchio, P.J., Fenton, J.W., Malik, A.B., 1986. Thrombin-induced increases in albumin permeability across the endothelium. J. Cell. Physiol. 128, 96-104.
6. Goeckeler, Z.M., Wysolmeraki, R.B., 1995. Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation. J. Cell Biol. 130, 613-627.
7. Goldblum, S.E., Ding, X., Funk, S.E., Sage, E.H., 1994. SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function. Proc. Natl. Acad. Sci. USA 91, 3448-3452.
8. Gottlieb, A.I., Langille, B.L., Wong, M.K., Kim, D.W., 1991. Structure and function of endothelial cytoskeleton. Lab. Invest. 65, 123-137.
9. Killackey, J.J.F., Johnston, M.G., Movat, H.Z., 1986. Increased permeability of microcarrier-cultured endothelial monolayers in response to histamine and thrombin. A model for the in vitro study of increased vasopermeability. Am. J. Pathol. 122, 50-61.
10. Kuo, S.C., Lee, H.Z., Juang, J.P., Lin, Y.T., Wu, T.S., Chang, J.J., Lednicer, D., Paull, K.D., Lin, C.M., Hamel, E., Lee, K.H., 1993. Synthesis and cytotoxicity of 1, 6, 7, 8-substituted 2-(4′-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin. J. Med. Chem. 36, 1146-1156.
11. Langeler, E.G., Van Hinsbergh, V.W.M., 1991. Norepinephrine and iloprost improve barrier function of human endothelial cell monolayers: role of cAMP. Am. J. Physiol. 260, C1052-C1059.
12. Langeler, E.G., Snelting-Havinga, I., Van Hinsbergh, V.W.M., 1989. Passage of low density lipoproteins through monolayers of human arterial endothelial cells. Effects of vasoactive substances in an in vitro model. Arteriosclerosis 9, 550-559.
13. Lee, H.Z., 1997. Inhibitory effect of 2-phenyl-4-quinolone on serotonin-mediated changes in the morphology and permeability of endothelial monolayers. Eur. J. Pharmacol. 335, 245-254.
14. 2 modulation of endothelial monolayer paracellular barrier function. J. Cell. Physiol. 167, 204-212.
15. Majno, G., Palade, G.E., 1961. Studies on inflammation. The effect of histamine and serotonin on vascular permeability: an electron microscopic study. J. Biophys. Biochem. Cytol. 11, 571-605.
16. Majno, G., Gilmore, V., Leventhal, M., 1967. On the mechanism of vascular leakage caused by histamine-type mediators. A microscopic study in vivo. Circ. Res. 21, 833-847.
17. Majno, G., Shea, S.M., Leventhal, M., 1969. Endothelial contraction induced by histamine type mediators: an electron microscope study. J. Cell Biol. 42, 647-672.
18. Patterson, C.E., Davis, H., Schaphorst, K.L., Garcia, J.G.N., 1994. Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial cell barrier dysfunction. Microvasc. Res. 48, 212-235.
19. Phillips, P.G., Lum, H., Malik, A.B., Tsan, M., 1989. Phallicidin prevents thrombin-induced increases in endothelial permeability to albumin. Am. J. Physiol. 257, C562-C567.
20. Rotrosen, D., Gallin, J.I., 1986. Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin and promotes albumin diffusion across cultured endothelial monolayers. J. Cell Biol. 103, 2379-2387.
21. Schnittler, H., Franke, R.P., Drenckhahn, D., 1989. Role of the endothelial actin filament cytoskeleton in rheology and permeability. Z. Kardiol. 78, 1-4.
22. Schnittler, A., Wilke, A., Gress, T., Suttorp, N., Drenckhahn, D., 1990. Role of actin and myosin in the control of paracellular permeability in pig, rat, and human vascular endothelium. J. Physiol. 431, 379-401.
23. Sharma, H.S., Cervos Navarro, J., 1990. Brain oedema and cellular changes induced by acute heat stress in young rats. Acta Neurochir. Suppl. Wien. 51, 383-386.
24. Shasby, D.M., Shasby, S.S., Sullivan, J.M., Peach, M.J., 1982. Role of endothelial cell cytoskeleton in control of endothelial permeability. Circ. Res. 51, 657-661.
25. Stasek, J.E., Garcia, J.G.N., 1992. Role of protein kinase C in thrombinmediated endothelial cell activation. Semin. Thromb. Hemost. 18, 117-125.
26. 77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers. J. Cell. Physiol. 153, 62-75.
27. Stelzner, T.J., Weil, J.V., O'Brien, R.F., 1989. Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties. J. Cell. Physiol. 139, 157-166.
28. Vehar, G.A., Davie, E.W., 1977. Formation of a serine enzyme in the presence of bovine factor VIII (antihemophilic factor) and thrombin. Science 197, 374-376.
29. Wang, J.P., Hsu, M.F., Raung, S.L., Kuo, S.C., 1994. Suppressive effect of 2-phenyl-4-quinolone (YT-1) on hind-paw edema and cutaneous vascular plasma extravasation in mice. Naunyn-Schmiedeberg's Arch. Pharmacol. 349, 324-330.
30. Wong, M.K.K., Gottlieb, A.I., 1986. Endothelial cell monolayer integrity: I. Characterization of dense peripheral band of microfilaments. Arteriosclerosis 6, 212-219.
31. Wong, M.K.K., Gottlieb, A.I., 1990. Endothelial monolayer integrity. Perturbation of F-actin filaments and the dense peripheral band-vinculin network. Arteriosclerosis 10, 76-84.
32. Wysolmerski, R.B., Lagunoff, D., Dahms, T., 1984. Ethchlorvynol-induced pulmonary edema in rats. An ultrastructural study. Am. J. Pathol. 115, 447-457.