Pulmonary actions of anandamide, an endogenous cannabinoid receptor agonist, in guinea pigs

European Journal of Pharmacology

Volumn 355, Issue 1, 1998, Pages 57-66

  Stengel, Peter W ^a   Rippy, Marian K ^a   Cockerham, Sandra L ^a   Devane, William A ^b   Silbaugh, Steven A ^a  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

9 Tetrahydrocannabinol; Airway obstruction; Asthma; Cannabinoid; Inflammation, pulmonary; Pulmonary gas trapping

Indexed keywords

ANANDAMIDE; CALCIMYCIN; CANNABINOID RECEPTOR;

AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; LUNG COMPLIANCE; LUNG FUNCTION; LUNG GAS EXCHANGE; LUNG VENTILATION; MALE; PNEUMONIA; PRIORITY JOURNAL;

AEROSOLS; AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONIC ACIDS; BRONCHODILATOR AGENTS; CALCIMYCIN; GUINEA PIGS; INJECTIONS, INTRAVENOUS; LUNG; LUNG COMPLIANCE; MALE; POLYUNSATURATED ALKAMIDES; PULMONARY VENTILATION; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TIDAL VOLUME;

EID: 0031693763     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00472-5     Document Type: Article

References (38)

1. 9-THC on pulmonary smooth muscle function in the guinea pig. Toxicol. Appl. Pharmacol. 41, 321-328.
2. Amdur, M.O., Mead, J., 1958. Mechanics of respiration in unanesthetized guinea pigs. J. Appl. Physiol. 192, 364-368.
3. Audette, C.A., Burstein, S., 1990. Inhibition of leukocyte adhesion by the in vivo and the in vitro administration of cannabinoids. Life Sci. 47, 753-759.
4. Burstein, S.H., Audette, C.A., Breuer, A., Devane, W.A., Colodner, S., Doyle, S.A., Mechoulam, R., 1992. Synthetic nonpsychotropic cannabinoids with potent anti-inflammatory, analgesic and leukocyte antiadhesion activities. J. Med. Chem. 35, 3135-3141.
5. Childers, S.R., Sexton, T., Roy, M.B., 1994. Effects of anandamide on cannabinoid receptors in rat brain membranes. Biochem. Pharmacol. 47, 711-715.
6. Crawley, J.N., Corwin, R.L., Robinson, J.K., Felder, C.C., Devane, W.A., Axelrod, J., 1993. Anadamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents. Pharmacol. Biochem. Behav. 46, 967-972.
7. Deutsch, D.G., Chin, S.A., 1993. Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem. Pharmacol. 46, 791-796.
8. Devane, W.A., Hanus, L., Breuer, A., Pertwee, R.G., Stevenson, L.A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., Mechoulam, R., 1992. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949.
9. Dewey, W.L., 1986. Cannabinoid pharmacology. Pharmacol. Rev. 38, 151-178.
10. Felder, C.C., Briley, E.M., Axelrod, J., Simpson, J.T., Mackie, K., Devane, W.A., 1993. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc. Natl. Acad. Sci. 90, 7656-7660.
11. Fride, E., Mechoulam, R., 1993. Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent. Eur. J. Pharmacol. 231, 313-314.
12. Ho, P.P.K., Esterman, M., 1979. Calcium ionophore A23187 induced anaphylaxis in guinea pig. Pharmacologist 21, 154.
13. Hollister, L.E., 1986. Health aspects of cannabis. Pharmacol. Rev. 38, 1-20.
14. 9-tetrhydrocannabinol in the rat. Eur. J. Pharmacol. 24, 1-7.
15. Kriseman, T., Underwood, D.C., Hyman, A.L., Kadowitz, P.J., 1986. Analysis of airway responses to A23187 in the cat. J. Pharmacol. Exp. Ther. 239, 395-399.
16. Lefort, J., Vargaftig, B.B., 1978. Role of platelets in aspirin-sensitive bronchoconstriction in the guinea pig: interactions with salicylic acid. Br. J. Pharmacol. 63, 35-42.
17. Mackie, K., Devane, W.A., Hille, B., 1993. Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol. Pharmacol. 44, 498-503.
18. Mercer, T.T., Tillery, M.I., Chow, H.Y., 1968. Operating characteristics of some compressed air nebulizers. Am. Ind. Hyg. Assoc. 29, 66-78.
19. Mercer, T.T., Tillery, M.I., Newton, G.J., 1970. A multi-stage, low flow rate cascade impactor. J. Aerosol Sci. 1, 9-15.
20. Misawa, M., Kawamura, T., Takenouchi, K., 1989. A new bronchial asthma model using calcium ionophore A23187 in guinea pigs. Jpn. J. Pharmacol. 51, 446-449.
21. 14C] as a substrate for anandamide amidase. Life Sci. 56, 1999-2005.
22. Patterson, R., Harris, K.E., Greenberger, P.A., 1979. Ionophore and arachidonic acid stimulation of airway responses in Rhesus monkeys. J. Clin. Invest. 67, 67-72.
23. Salari, H., Borgeat, P., Fournier, M., Hebert, J., Pelletier, G., 1985. Studies on the release of leukotrienes and histamine by human lung fragments upon immunologic and nonimmunologic stimulation: effects of nordihydroguaiaretic acid, aspirin, and sodium cromoglycate. J. Exp. Med. 162, 1904-1915.
24. Sautebin, L., Vigano, T., Grassi, E., Crivellari, M.T., Galli, G., Berti, F., Mezzetti, M., Folco, G., 1985. Release of leukotriene, induced by the Ca+ + ionophore A23187, from human lung parenchyma in vitro. J. Pharmacol. Exp. Ther. 234, 217-221.
25. Silbaugh, S.A., Wolff, R.K., Johnson, W.K., Mauderly, J.L., Macken, C.A., 1981. Effect of sulfuric acid aerosols on pulmonary function of guinea pigs. J. Toxicol. Environ. Health 7, 339-352.
26. Silbaugh, S.A., Stengel, P.W., Dillard, R.D., Bemis, K.G., 1987. Pulmonary gas trapping in the guinea pig and its application in pharmacological testing. J. Pharmacol. Methods 18, 295-303.
27. Smith, P.B., Compton, D.R., Welch, S.P., Razdan, R.K., Mechoulam, R., Martin, B.R., 1994. The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice. J. Pharmacol. Exp. Ther. 270, 219-227.
28. 9-tetrahydrocannabinol (THC). J. Pharmacol. Exp. Ther. 186, 646-655.
29. Stengel, P.W., Silbaugh, S.A., 1986. Mechanisms of gas loss from normal and hyperinflated excised guinea pig lungs. Respir. Physiol. 63, 129-138.
30. Stengel, P.W., Silbaugh, S.A., 1989. Reversal of A23187-induced airway constriction in the guinea pig. J. Pharmacol. Exp. Ther. 248, 1084-1090.
31. Stengel, P.W., Pechous, P.A., Silbaugh, S.A., 1987. Mechanism of A23187-induced airway obstruction in the guinea pig. Prostaglandins 33, 567-577.
32. Stengel, P.W., Williams, G.D., Silbaugh, S.A., 1991. A23187-induced pulmonary gas trapping and inflammation in the guinea pig. Agents Actions 32, 270-276.
33. 9-tetrahydrocannabinol in healthy young men. N. Eng. J. Med. 289, 336-341.
34. Tashkin, D.P., Shapiro, B.J., Lee, Y.E., Harper, C.E., 1975. Effects of smoked marijuana in experimentally induced asthma. Am. Rev. Respir. Dis. 112, 377-386.
35. 9-tetrahydrocannabinol in healthy and asthmatic subjects. Am. Rev. Respir. Dis. 115, 57-65.
36. Vachon, L., Fitzgerald, M.X., Solliday, N.H., Gould, I.A., Gaensler, E.A., 1973. Single-dose effect of marihuana smoke: bronchial dynamics and respiratory-center sensitivity in normal subjects. N. Eng. J. Med. 288, 985-989.
37. Vogel, Z., Barg, J., Levy, R., Saya, D., Heldman, E., Mechoulam, R., 1993. Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. J. Neurochem. 61, 352-355.
38. Wiley, J., Balster, R., Martin, B., 1995. Discriminative stimulus effects of anandamide in rats. Eur. J. Pharmacol. 276, 49-54.