New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. I. Producing organism and medium components

Journal of Antibiotics

Volumn 51, Issue 7, 1998, Pages 640-646

  Kimura, Ken Ichi ^a   Kagami, Shinobu ^a   Ikeda, Yoshikazu ^a   Takahashi, Hidetoshi ^a   Yoshihama, Makoto ^a   Kusakabe, Hiroo ^b   Osada, Hiroyuki ^b   Isono, Kiyoshi ^b  

^a SNOW BRAND MILK PRODUCTS CO LTD   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; LIPOSIDOMYCIN DERIVATIVE; PEPTIDOGLYCAN; PROTEIN SYNTHESIS INHIBITOR; SUCROSE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG STRUCTURE; FERMENTATION; GLYCOPROTEIN SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MYCOBACTERIUM PHLEI; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; STREPTOMYCES; TAXONOMY; THIN LAYER CHROMATOGRAPHY;

STREPTOMYCES;

EID: 0031690618     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.51.640     Document Type: Article

References (16)

1. BUGG, T. D. H. & C. T. WALSH: Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: Enzymology, antibiotics, and antibiotic resistance. Nat. Prod. Rep. 9: 199-215, 1992
2. BUGG, T. D. H. & P. E. BRANDISH: From peptidoglycan to glycoproteins: Common features of lipid-linked oligosaccharide biosynthesis; FEMS Microbiology Letters 119: 255-262, 1994
3. ISONO, K.; M. URAMOTO, H. KUSAKABE, K. KIMURA, K. IZAKI, C. C. NELSON & J. A. MCCLOSKEY: Liposidomycins: novel nucleoside antibiotics which inhibit bacterial peptidoglycan synthesis. J. Antibiotics 38: 1617-1621, 1985
4. UBUKATA, M.; K. ISONO, K. KIMURA, C. C. NELSON & J. A. MCCLOSKEY: The structure of liposidomycin B, an inhibitor of bacterial peptidoglycan synthesis. J. Am. Chem. Soc. 110: 4416-4417, 1988
5. UBUKATA, M.; K. KIMURA, K. ISONO, C. C. NELSON, J. M. GREGSON & J. A. MCCLOSKEY: Structure elucidation of liposidomycins, a class of complex lipid nucleoside antibiotics. J. Org. Chem. 57: 6392-6403, 1992
6. KIMURA, K.; N. MIYATA, G. KAWANISHI, Y. KAMIO, K. IZAKI & K. ISONO: Liposidomycin C inhibits phospho-N-acetylmuramyl-pentapeptide transferase in peptidoglycan synthesis. Agric. Biol. Chem. 53: 1811-1815, 1989
7. TAMURA, G.: "Tunicamycin", Japan Scientific Press, Tokyo, 1982
8. INUKAI, M.; F. ISONO & A. TAKATSUKI: Selective inhibition of the bacterial translocase reaction in peptidoglycan synthesis by mureidomycins. Antimicrob. Agents. Chemother. 37: 980-983, 1993
9. BRANDISH, P. E.; K. KIMURA, M. INUKAI, R. SOUTHGATE, J. T. LONSDALE & T. D. H. BUGG: Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: inhibition of phospho-N-acetylmuramyl-pentapeptide translocase from Escherichia coli. Antimicrob. Agents Chemother. 40: 1640-1644, 1996
10. MUROI, M.; K. KIMURA, H. OSADA, M. INUKAI & A. TAKATSUKI: Liposidomycin B inhibits in vitro formation of polyprenyl(pyro)phosphate N-acetylglucosamine, an intermediate in glycoconjugate biosynthesis. J. Antibiotics 50: 103-104, 1997
11. KIMURA, K.; Y. IKEDA, S. KAGAMI, M. YOSHIHAMA, M. UBUKATA, Y. ESUMI, H. OSADA & K. ISONO: New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. II. Isolation and structure elucidation. J. Antibiotics 51: 647-659, 1998
12. KIMURA, K.; Y. IKEDA, S. KAGAMI, M. YOSHIHAMA, K. SUZUKI, H. OSADA & K. ISONO: Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins. J. Antibiotics to be submitted
13. SHIRLING, E. B. & D. GOTTLIEB: Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313-340, 1966
14. LECHEVALIER, M. P. & H. A. LECHEVALIER: Chemical composition as a criteria in the classification of aerobic actinomycetes. Int. J. Syst. Bacteriol. 20:435-443, 1970
15. BECKER, B.; M. P. LECHEVALIER, R. E. GORDON & H. A. LECHEVALIER: Rapid differentiation between Nocardia and Streptomyces by paper chromatography of whole-cell hydrolysates. Appl. Microbiol. 12: 421-423, 1964
16. PRIDHAM, T. G. & H. D. TRESNER: Family VII. Streptomycetaceae Waksman and Henrici 1943, 339. In Bergey's Manual of Determinative Bacteriology, 8th Ed., Eds., R. E. BUCHANAN and N. E. GIBBONS, pp. 747-845, Williams and Wilkins Co., 1974