Myocardial uptake of the fatty acid analog 14-fluorine-18-fluoro-6- thia-heptadecanoic acid in comparison to beta-oxidation rates by tritiated palmitate

Journal of Nuclear Medicine

Volumn 39, Issue 10, 1998, Pages 1690-1696

  Stone, Charles K ^a   Pooley, Robert A ^b   DeGrado, Timothy R ^b   Renstrom, Britta ^b   Nickles, Robert J ^b   Nellis, Stephen H ^b   Liedtke, A James ^b   Holden, James E ^b  

^a University of Wisconsin Health   (United States)

^b NONE

Author keywords

14 fluorine 18 fluoro 6 thia heptadecanoic acid; Fatty acid metabolism; Fatty acid tracer; Fatty acids; Myocardial metabolism

Indexed keywords

14 FLUORO 6 THIAHEPTADECANOIC ACID F 18; FATTY ACID DERIVATIVE; LACTIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG RETENTION; EXTRACORPOREAL CIRCULATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; FATTY ACIDS; FLUORINE RADIOISOTOPES; HEART; LACTIC ACID; MYOCARDIUM; OXIDATION-REDUCTION; PALMITATES; RADIOPHARMACEUTICALS; SWINE; TRITIUM;

EID: 0031690342     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Schön HR, Schelbert HR, Najafi A, et al. C-11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. I. Kinetics of C-11 palmitic acid in normal myocardium. Am Heart J 1982;103:532-547.
2. Schön HR, Schelbert HR, Najafi A, et al. C-11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. II. Kinetics of C-11 palmitic acid in acutely ischemic myocardium. Am Heart J 1982;103:548-561.
3. Bergmann SR, Weinheimer CJ, Markham J, Herrero P. Quantitation of myocardial fatty acid metabolism using PET. J Nucl Med 1996;37:1723-1730.
4. DeGrado TR, Holden JE, Ng CK, Raffel DM, Gatley SJ. Comparison of 16-iodohexadeanoic acid (IHDA) and 15-p-iodophenylpentadecanoic acid (IPPA) metabolism and kinetics in the isolated rat heart. Eur J Nucl Med 1988;14:600-606.
5. DeGrado TR, Holden JE, Ng CK, Raffel DM, Gatley SJ. β-Methyl-15-p-iodophenylpentadecanoic acid metabolism and kinetics in the isolated rat heart. Eur J Nucl Med 1989;15:78-80.
6. 18F]fluoro-6-thia-heptadecanoic acid (FTHA). J Labeled Comp Radiopharm 1991;29:989-995.
7. Skrede S, Narce M, Bergseth S, Bremer J. The effects of alkylthioacetic acids (3-thia fatty acid) on fatty acid metabolism in isolated hepatocytes. Biochim Biophys Acta 1989;1005:296-302.
8. 18F]fluoro-6-thia-heptadecanoic acid (FTHA): evaluation in mouse of a new probe of myocardial utilization of long chain fatty acids. J Nucl Med 1991;32:1888-1896.
9. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7.
10. Nickles RJ, Gatley SJ, Votaw JR, Kornguth ML. Production of reactive fluorine-18. Int J Radiat Appl Instrum Part A 1986;37:649-661.
11. 14C]deoxyglucose as markers of glycolysis in reperfused myocardium. Circ Res 1992;71:689-700.
12. Renstrom B, Nellis SH, Liedtke AJ. Metabolic oxidation of glucose during early myocardial reperfusion. Circ Res 1989;65:1094-1101.
13. Liedtke AJ, DeMaison L, Eggleston AE, Cohen LM, Nellis SH. Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res 1988;62:535-542.
14. Renstrom B, Nellis SH, Liedtke AJ. Metabolic oxidation of pyruvate and lactate during early myocardial reperfusion. Circ Res 1990;66:282-288.
15. Nellis SH, Liedtke AJ, Renstrom B. Distribution of carbon flux within fatty acid utilization during myocardial ischemia and reperfusion. Circ Res 1991;69:779-790.
16. Rose CP, Goresky CA. Constraints on the uptake of labeled palmitate by the heart. The barriers at the capillary and sarcolemmal surfaces and the control of intracellular sequestration. Circ Res 1977;41:534-545.
17. Saddik M, Lopaschuk G. Myocardial triglyceride turnover during reperfusion of isolated rat hearts subjected to a transient period of global ischemia. J Biol Chem 1992;267:3825-3831.
18. Abu-Erreish GM, Neely JR, Whitmer JT, Whitman V, Sanadi DR. Fatty acid oxidation by isolated perfused working hearts of aged rats. Am J Physiol 1977;232:E258-E262.
19. Hamilton JG, Comai K. Rapid separation of neutral lipids, free fatty acids and polar lipids using prepacked silica Sep-Pak columns. Lipids 1988;23:1146-1149.
20. Pooley RA. Evaluation of 14(R,S)[fluorine-18]fluoro-6-thia-heptadecanoic acid (FTHA) as a positron emission tomography fatty acid tracer of β-oxidation in the heart. [PhD thesis]. Madison, WI: University of Wisconsin-Madison; 1995.
21. Gandemer GG, Durand G, Pascal G. Relative contribution of the main tissues and organs to body fatty acid synthesis in the rat. Lipids 1983;18:223-228.
22. Van der Vusse GJ, Roemen THM, Flameng W, Reneman RS. Serum myocardium gradients of nonesterified fatty acids in the dog, rat and man. Biochem Biophys Acta 1983;752:361-370.
23. 14C]fatty acid oxidation. Biochem Med Metab Biol 1986;35:248-259.
24. Sherratt HSA, Watmough NJ, Johnson MA, Turnbull DM. Methods for study of normal and abnormal skeletal muscle mitochondria. Methods Biochem Anal 1988;33: 243-335.
25. 3H]hexadecanoate: application to skeletal muscle and the use of inhibitors as models of metabolic disease. Biochem Med Metab Biol 1992;47:145-156.
26. 11C-palmitate. Circulation 1982;65:731-738.
27. Grover-McKay M, Schelbert HR, Schwaiger M, et al. Identification of impaired metabolic reserve by atrial pacing in patients with significant coronary artery stenosis. Circulation 1986;74:281-292.
28. Hansen CL, Jeo J, Oliner C, Van Decker W, Iskandrian AS. Prediction of improvement in left ventricular function with iodine-123-IPPA after coronary revascularization. J Nucl Med 1995;36:1987-1993.
29. Goodman MM, Knapp FF Jr, Callahan AP, Ferren LA. A new well-retained myocardial imaging agent: radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid. J Nucl Med 1982;23:904-908.
30. Fagret D, Bontemps L, Apparu M, et al. Kinetics of iodomethylated hexadecanoic acid metabolism in the rat myocardium: influence of the number and the position of methyl radicals. Int J Nucl Med Biol 1985;12:363-367.
31. Chouraqui P, Maddahi J, Henkin R, Karesh SM, Galie E, Berman DS. Comparison of myocardial imaging with iodine-123-iodophenyl-9-methyl pentadecanoic acid and thallium-201-chloride for assessment of patients with exercise-induced myocardial ischemia. J Nucl Med 1991;32:447-452.
32. Sloof GW, Visser FC, Eenige van MJ, et al. Comparison of uptake, oxidation and lipid distribution of 17-iodoheptadecanoic acid, 15-(p-iodophenyl)pentadecanoic acid and 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid in normal canine myocardium. J Nucl Med 1993;34:649-657.
33. Knapp FF, Ambrose KR, Goodman MM. New radioiodinated methyl-branched fatty acids for cardiac studies. Eur J Nucl Med 1986;12(suppl):S39-S44.
34. 123I-beta-methyl-iodophenyl pentadecanoic acid (BMIPP): comparison of myocardial perfusion and fatty acid utilization in canine myocardial infarction (occlusion and reperfusion model). Eur J Nucl Med 1989;15:341-345.
35. Bianco JA, Pape LA, Alpert JS, et al. Accumulation of radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid in ischemic myocardium during acute coronary occlusion and reperfusion. J Am Coll Cardiol 1984;4:80-87.
36. 123I-labeled hexadecanoic acid. J Nucl Med 1977;17:1077-1082.
37. Geltman EM, Smith JL, Beecher D, Ludbrook PA, Ter-Pogossian MM, Sobel BE. Altered regional myocardial metabolism in congestive cardiomyopathy detected by positron tomography. Am J Med 1983;74:773-785.
38. Eisenberg JD, Sobel BE, Geltman EM. Differentiation of ischemic from nonischemic cardiomyopathy with positron emission tomography. Am J Cardiol 1987;59:1410-1414.