Isozymes of cyclic AMP-dependent protein kinases (PKA) in human lymphoid cell lines: Levels of endogenous cAMP influence levels of PKA subunits and growth in lymphoid cell lines

Journal of Cellular Physiology

Volumn 177, Issue 1, 1998, Pages 85-93

  Skålhegg, Bjørn Steen ^a   Johansen, Ann Kirsti ^a   Levy, Finn Olav ^a   Andersson, Kristin Brevik ^a,b   Aandahl, Einar Martin ^a   Blomhoff, Heidi Kiil ^a,b   Hansson, Vidar ^a   Taskén, Kjetil ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOENZYME; MESSENGER RNA;

ARTICLE; B LYMPHOCYTE; CELL GROWTH; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBUNIT; HUMAN; HUMAN CELL; LYMPHOID CELL; PRIORITY JOURNAL; RNA ANALYSIS; T LYMPHOCYTE;

B-LYMPHOCYTES; BLOTTING, NORTHERN; BLOTTING, WESTERN; BURKITT LYMPHOMA; CELL DIVISION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOENZYMES; JURKAT CELLS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LYMPHOMA, DIFFUSE; MULTIPLE MYELOMA; RNA, MESSENGER; T-LYMPHOCYTES; TRITIUM;

EID: 0031690341     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199810)177:1<85::AID-JCP9>3.0.CO;2-A     Document Type: Article

References (49)

1. Alhanaty, E., and Shaltiel, S. (1979) Limited proteolysis of the catalytic subunit of cAMP-dependent protein kinase: A membranal regulatory device. Biochem. Biophys. Res. Commun., 89:323-332.
2. Beebe, S.J., Holloway, R., Rannels, S.R., and Corbin, J.D. (1984) Two classes of cAMP analogs which are selective for the two different cAMP-binding sites of type II protein kinase demonstrate synergism when added together to intact adipocytes. J. Biol. Chem., 259:3539-3547.
3. Beebe, S.J., Øyen, O., Sandberg, M., Frøysa, A., Hansson, V., and Jahnsen, T. (1990) Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis, representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. Mol. Endocrinol., 4:465-75.
4. Beebe, S.J., and Corbin, J.D. (1986) Cyclic nucleotide-dependent protein kinases. Enzymes, 17:43-111.
5. Blomhoff, H.K., Smeland, E.B., Beiske, K., Blomhoff, R., Ruud, E., Bjøro, T., Pfeifer-Ohlsson, S., Watt, R., Funderud, S., Godal, T., and Ohlsson, R. (1987) Cyclic AMP-mediated suppression of normal and neoplastic B cell proliferation is associated with regulation of myc and Ha-ras protooncogenes. J. Cell. Physiol., 131:426-433.
6. Bradford, M.M. (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72:248-254.
7. Burton, K.A., Johnson, B.D., Hausken, Z.E., Westenbroek, R.E., Idzerda, R.L., Scheuer, T., Scott, J.D., Catterall, W.A., and McKnight, G.S. (1997) Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A., 94:11067-11072.
8. Bøyum, A. (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand. J. of Lab. Invest., 97:77-82.
9. Clegg, C.H., Cadd, G.G., and McKnight, G.S. (1988) Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A., 85:3703-3707.
10. Cobb, C.E., and Corbin, J.D. (1988) Purification of cAMP-free and cAMP-bound forms of bovine heart cAMP-dependent protein kinase holoenzyme. Methods Enzymol., 159:202-208.
11. Corbin, J.D., Keely, S.L., and Park, C.R. (1975) The distribution and dissociation of cyclic adenosine 3′:5′-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues. J. Biol. Chem., 250:218-225.
12. Corbin, J.D., Sugden, P.H., West, L., Flockhardt, D.A., Lincoln, T.M., and McCarthy, D. (1978) Studies on the properties and mode of action of purified regulatory subunit of bovine heart adenosine 3′:5′-monophosphate-dependent protein kinase. J. Biol. Chem., 253:3997-4003.
13. DiFrancesco, D., and Tortora, P. (1991) Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature, 351:145-147.
14. Døskeland, S.O. (1978) Evidence that rabbit muscle protein kinase has two kineatically distinct binding sites for adenosine 3́:5́-cyclic monophosphate. Biochem. Biophys. Res. Commun., 83:542-549.
15. Funderud, S., Erikstein, B., Åsheim, H.C., Nustad, K., Stokke, T., Blomhoff, H.K., Holte, H., and Smeland, E.B. (1990) Functional properties of CD19+ B lymphocytes positively selected from buffy coats by immunomagnetic separation. Eur. J. Immunol., 20:201-206.
16. Holte, H., Stokke, T., Smeland, E., Watt, R., Blomhoff, H.K., Kaalhus, O., and Ohlsson, R. (1989) Levels of myc protein, as analyzed by flow cytometry, correlate with cell growth potential in malignant B-cell lymphomas. Int. J. Cancer, 43:164-170.
17. Huang, L.J., Durick, K., Weiner, J.A., Chun, J., and Taylor, S.S. (1997a) Identification of a novel protein kinase A anchoring protein that binds both type I and II regulatory subunits. J. Biol. Chem., 272:8057-8064.
18. Huang, L.J., Durick, K., Weiner, J.A., Chun, J., and Taylor, S.S. (1997b) D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domian. Proc. Natl. Acad. Sci. U.S.A., 94:11184-11189.
19. Kammer, G.M. (1988) The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. Immunol. Today, 9:222-229.
20. Kemp, B.E., Benjamini, E., and Krebs, E.G. (1976) Synthetic hexapeptide substrates and inhibitors of 3′:5′-cyclic AMP-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A., 73:1038-1042.
21. Keryer, G., Rios, R.M., Landmark, B.F., Skålhegg, B.S., Lohmann, S.M., and Bornens, M. (1993) A high-affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II in the ccntrosome of human cells. Exp. Cell Res., 204:230-240.
22. Krebs, E.G., and Beavo, J.A. (1979) Phosphorylation-dephosphorylation of enzymes. Annu. Rev. Biochem., 45:923-959.
23. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227:680-685.
24. Lea, T., Vartdal, F., Davies, C., and Ugelstad, J. (1985) Magnetic monosized polymer particles for fast and specific fractionation of human mononuclear cells. Scand. J. Immunol., 22:207-216.
25. Levy, F.O., Øyen, O., Sandberg, M., Taskén, K., Eskild, W., Hansson, V., and Jahnsen, T. (1988) Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3′,5′-cyclic adenosine monophosphate-dependent protein kinase from human testis. Mol. Endocrinol., 2:1364-1373.
26. 2) with the antigen receptor during antiimmunoglobulin-induced B cell activation. Eur. J. Immunol., 26:1290-1296.
27. Lorimer, I.A.J., and Sanwal, B.D. (1989) Regulation of cyclic AMP-dependent protein kinase levels during skeletal myogenesis. Biochem. J., 264:305-308.
28. Melsom, H., Funderud, S., Lie, S.O., and Godal, T. (1984) The great majority of childhood lymphoblastic leukaemias are identified by monoclonal antibodies as neoplasias of the B-cell progenitor compartment. Scand. J. Haematol., 33:27-34.
29. Nakamura, T. and Gold, G.H. (1987) A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature, 325:442-444.
30. Øyen, O., Sandberg, M., Eskild, W., Levy, F.O., Knutsen, G., Beebe, S., Hansson, V., and Jahnsen, T. (1988) Differential regulation of messenger ribonucleic acids for specific subunits of cyclic adenosine 3′,5′-monophosphate (cAMP)-dependent protein kinase by cAMP in rat Sertoli cells. Endocrinology, 122:2658-2666.
31. α of cAMP-dependent protein kinase encodes an alternate amino-terminal region. FEBS Lett., 246:57-64.
32. Richardson, J.M., Howard, P., Massa, J.S., and Maurer, R.A. (1990) Post-transcriptional regulation of cAMP-dependent protein kinase activity by CAMP in GH3 pituitary tumor cells. Evidence for increased degradation of catalytic subunit in the presence of cAMP. J. Biol. Chem., 265:13635-13640.
33. Rios, R.M., Celati, C., Lohmann, S.M., Bornens, M., and Keryer, G. (1992) Identification of a high affinity binding protein for the regulator subunit RIIβ of cAMP-dependent protein kinase in Golgi enriched membranes of human lymphoblasts. EMBO J., 11:1723-1731.
34. Rosenmund, C., Carr, D.W., Bergeson, S.E., Nilaver, G., Scott, J.D., and Westbrook, G.L. (1994) Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons. Nature, 368:853-856.
35. Roskoski, R. (1983) Assays of protein kinase. Methods Enzymol., 99:3-6.
36. Rubin, C.S. (1994) A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. Biochim. Biophys. Acta, 1224:467-479.
37. Sandberg, M., Taskén, K., Øyen, O., Hansson, V., and Jahnsen, T. (1987) Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis. Biochem. Biophys. Res. Commun., 149:939-945.
38. Scott, J.D. (1991) Cyclic nucleotide-dependent protein kinases. Pharmacol. Ther., 50:123-145.
39. Skålhegg B.S., Landmark, B.F., Døskeland, S.O., Hansson, V., Lea, T., and Jahnsen, T. (1992a) Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3′,5′-cyclic adenosine monophosphate on cell replication in human T lymphocytes. J. Biol. Chem., 267:15707-15714.
40. Skålhegg, B.S., Landmark, B.F., Foss, K.B., Lohmann, S.M., Hansson, V., Lea, T., and Jahnsen, T. (1992b) Identification, purification, and characterization of subunits of cAMP-dependent protein kinase in human testis. Reverse mobilities of human RII alpha and RII beta on sodium dodecyl sulfate-polyacrylamide gel electrophoresis compared with rat and bovine RIIs. J. Biol. Chem., 267:5374-5379.
41. Skålhegg, B.S., Rasmussen, A.M., Taskén, K., Hansson, V., Jahnsen, T., and Lea, T. (1994a) Cyclic AMP sensitive signalling by the CD28 marker requires concomitant stimulation by the T-cell antigen receptor (TCR/CD3) complex. Scand. J. Immunol., 40:201-208.
42. Skålhegg, B.S., Taskén, K., Hansson, V., Huitfeldt, H.S., Jahnsen, T., and Lea, T. (1994b) Location of cAMP-dependent protein kinase type I with the TCR/CD3 complex. Science, 263:84-87.
43. Smeland, E.B., Funderud, S., Ruud, E., Blomhoff, H.K., and Godal, T. (1985) Characterization of two murine monoclonal antibodies reactive with human B cells. Their use in a high-yield, high-purity method for isolation of B cells and utilization of such cells in an assay for B-cell stimulating factor. Scand. J. Immunol., 21:205-214.
44. Solberg, R., Taskén, K., Keiserud, A., and Jahnsen, T. (1991) Molecular cloning cDNA structure and tissue-specific expression of the human regulatory subunit RIβ of cAMP-dependent protein kinases. Biochem. Biophys. Res. Commun., 176:166-172.
45. Steinberg, R.A., and Agard, D.A. (1981) Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP. J. Biol. Chem., 256:10731-10734.
46. Taskén K., Andersson, K.B., Skålhegg, B.S., Taskén, K.A., Hansson, V., Jahnsen, T., and Blomhoff, H.K. (1993a) Reciprocal regulation of mRNA and protein for subunits of cAMP-dependent protein kinase (RIα and Cα) by cAMP in a neoplastic B cell line (Reh). J. Biol. Chem., 268:23483-23489.
47. Taskén, K., Skålhegg, B.S., Solberg, R., Andersson, K.B., Taylor S.S., Lea, T., Blomhoff, H.K., Jahnsen, T., and Hansson, V. (1993b) Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation RIα-RIβ heterodimeric complexes. J. Biol. Chem., 268:21276-21283.
48. Taskén, K., Solberg, R., Foss, K.B., Skålhegg, B.S., Hansson, V., and Jahnsen, T. (1995) Cyclic AMP-dependent protein kinase. In: Facts-book on protein kinases. D.G. Hardie and S.K. Hanks, eds. Academic Press, London, pp. 58-63.
49. Torgersen, K.M., Vaage, J.T., Levy, F.O., Hansson, V., Rolstad, B., and Taskén, K. (1997) Selective activation of cAMP-dependent protein kinase type I inhibits rat Natural Killer cell cytotoxicity. J. Biol. Chem., 272:5495-5500.