Protein turnover and energy expenditure increase during exogenous nutrient availability in sickle cell disease

American Journal of Clinical Nutrition

Volumn 68, Issue 3, 1998, Pages 607-614

  Borel, Myfanwy J ^a   Buchowski, Maciej S ^a   Turner, Ernest A ^a   Goldstein, Richard E ^a   Flakoll, Paul J ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adults; African Americans; Amino acids; Carbohydrate metabolism; Energy expenditure; Lipolysis; Nutrient availability; Nutrient infusion; Protein metabolism; Sickle cell anemia; Sickle cell disease

Indexed keywords

AMINO ACID; GLUCOSE; HEMOGLOBIN S; LIPID; PROTEIN;

ADULT; ARTICLE; BASAL METABOLIC RATE; BODY COMPOSITION; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; GLUCOSE METABOLISM; HORMONE BLOOD LEVEL; HUMAN; LIPID METABOLISM; LIPOLYSIS; MALE; NEGRO; PROTEIN METABOLISM; SICKLE CELL ANEMIA;

EID: 0031690133     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/68.3.607     Document Type: Article

References (43)

1. Ingram VM. Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin. Nature 1957;180:326-8.
2. Serjeant GR. Sickle cell disease. 2nd ed. Oxford, United Kingdom: Oxford University Press, 1992.
3. Borel MJ, Buchowski MS, Turner EA, Peeler BB, Goldstein RE, Flakoll PJ. Alterations in basal nutrient metabolism increase resting energy expenditure in sickle cell disease. Am J Physiol 1998;274:E357-64.
4. Badaloo A, Jackson AA, Jahoor F. Whole body protein turnover and resting metabolic rate in homozygous sickle cell disease. Clin Sci 1989,77:93-7.
5. Gray NT, Bartlett JM, Kolasa KM, Marcuard SP, Holbrook CT, Horner RD. Nutritional status and dietary intake of children with sickle cell anemia. Am J Pediatr Hematol Oncol 1992;14:57-61.
6. Salman EK, Haymond MW, Bayne E, et al. Protein and energy metabolism in prepubertal children with sickle cell anemia. Pediatr Res 1996;40:34-40.
7. Singhal A, Davies P, Sahota A, Thomas PW, Serjeant GR. Resting metabolic rate in homozygous sickle cell disease. Am J Clin Nutr 1993;57:32-4.
8. Singhal A, Davies P, Wierenga KJJ, Thomas P, Serjeant G. Is there an energy deficiency in homozygous sickle cell disease? Am J Clin Nutr 1997;66:386-90.
9. Heyman MB, Katz R, Hurst D, et al. Growth retardation in sickle-cell disease treated by nutritional support. Lancet 1985;1:903-6.
10. Rahbar F, Scott RB, July P. Studies in sickle cell anemia: preliminary observation on gastrointestinal digestion and absorption. J Natl Med Assoc 1977;69:103-4.
11. Alperin JB. Folic acid deficiency complicating sickle cell anemia: a study on the response to titrated doses of folic acid. Arch Intern Med 1967;120:298-306.
12. Metropolitan Life Insurance Company. New weight standards for men and women. Stat Bull Metropol Life Insur Co 1959;40:1-4.
13. Adams JG. Clinical laboratory diagnosis. In: Embury SH, Hebbel RP, Mohandas N, Steinberg MH, eds. Sickle cell disease: basic principles and clinical practice. New York: Raven Press, Ltd, 1994:457-68.
14. Akers R, Buskirk ER. An underwater weighing system utilizing "force cube" transducers. J Appl Physiol 1969;26:649-52.
15. Schutte JE, Townsend EJ, Hugg J, Shoup RF, Malina RM, Blomqvist CG. Density of lean body mass is greater in blacks than in whites. J Appl Physiol 1984;56:1647-9.
16. Abumrad NN, Rabin D, Diamond M, Lacy WW. Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism 1981;30:936-40.
17. Bier DM, Arnold KJ, Sherman WR, Holland WH, Holmes WF, Kipnis DM. In-vivo measurement of glucose and alanine metabolism with stable isotopic tracers. Diabetes 1977;26:1005-15.
18. Flakoll PJ, Hill JO, Abumrad NN. Acute hyperglycemia enhances proteolysis in normal man. Am J Physiol 1993;265:E715-21.
19. Wolfe RR. Radioactive and stable isotope tracers in biomedicine - principles and practice of kinetic analysis. New York: Wiley-Liss, 1992.
20. Evans NJ, Bamba M, Rombeau JL. Care of central venous catheters. In: Rombeau JL, Caldwell MD, eds. Clinical nutrition: parenteral nutrition. 2nd ed. Philadelphia: WB Saunders Company, 1993:353-66.
21. 2 breath tests. Am J Clin Nutr 1980;33:2375-85.
22. 2 enrichment. J Appl Physiol 1984;56:230-4.
23. National Research Council. Recommended dietary allowances. 10th ed. Washington, DC: National Academy Press, 1989.
24. Lloyd B, Burrin P, Smythe P, Alberti KGMM. Enzymic fluorometric continuous flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin Chem 1978;24:1724-9.
25. Goldstein DS, Feuerstein G, Izzo JL Jr, Kopin IJ, Keiser HR. Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in man. Life Sci 1981;28:467-75.
26. Morgan CR, Lazarow A. Immunoassay of insulin: two antibody system. Plasma insulin levels of normal, subdiabetic, and diabetic rats. Diabetes 1963;12:115-26.
27. Heinrikson R, Meredith SC. Amino acid analysis by reverse-phase HPLC: pre-column derivatization with phenylisothiocyanate. Anal Biochem 1984;136:65-74.
28. Nissen SL, Van Huysen C, Haymond MW. Measurement of branched-chain α-ketoacids in plasma by high performance liquid chromatography. J Chromatogr 1982;232:170-5.
29. Schwenk WF, Berg PJ, Beaufrere B, Miles JM, Haymond MW. Use of t-butyldimethylsilylation in the gas chromatographic/mass spectrometric analysis of physiologic compounds found in plasma using electron-impact ionization. Anal Biochem 1984;141:101-9.
30. 13C enrichment of carbon dioxide in breath and blood samples using the Finnigan MAT breath gas analysis system. Biomed Environ Mass Spectrom 1988;15:365-7.
31. Rosenblatt J, Wolfe RR. Calculation of substrate flux using stable isotopes. Am J Physiol 1988;254:E526-31.
32. 13C]leucine infusion in man: a method for measuring human intracellular tracer enrichment. Metab Clin Exp 1982;31:1105-12.
33. Allsop JR, Wolfe RR, Burke JF. Tracer priming the bicarbonate pool. J Appl Physiol 1978;45:137-9.
34. Garlick PJ, McNurlan MA, McHardy KC, et al. Rates of nutrient utilization in man measured by combined respiratory gas analysis and stable isotopic labelling: effect of food intake. Hum Nutr Clin Nutr 1987;41C:177-91.
35. Campbell PJ, Carlson MG, Hill JO, Nurjhan N. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol 1992;263:E1063-9.
36. Jequier E, Acheson K, Schutz Y. Assessment of energy expenditure and fuel utilization in man. Annu Rev Nutr 1987;7:187-208.
37. Reeds PJ, Fuller MF, Nicholson BA. Metabolic basis of energy expenditure with particular reference to protein. In: Garrow JS, Halliday D, eds. Substrate and energy metabolism. London: John Libbey and Co, Ltd, 1985:46-57.
38. Reeds PJ, Cadenhead A, Fuller MF, Lobley GE, McDonald JD. Protein turnover in growing pigs. Effects of age and food intake. Br J Nutr 1980;43:445-55.
39. Enwonwu CO, Xu X-X, Turner E. Nitrogen metabolism in sickle cell anemia: free amino acids in plasma and urine. Am J Med Sci 1990;300:366-71.
40. τmethylhistidine (3-methylhistidine) and muscle protein turnover: an overview. Fed Proc 1978;37:2291-300.
41. Flakoll PJ, Borel MJ, Wentzel LS, Williams PE, Lacy DB, Abumrad NN. The role of glucagon in the control of protein and amino acid metabolism in vivo. Metabolism 1994;43:1509-16.
42. Borel MJ, Beard JL, Farrell PA. Hepatic glucose production and insulin sensitivity and responsiveness in iron-deficient anemic rats. Am J Physiol 1993;264:E380-90.
43. Farrell PA, Beard JL, Druckenmiller M. Increased insulin sensitivity in iron-deficient rats. J Nutr 1988;118:1104-9.