Gas chromatographic determination of toxic quinolizidine alkaloids in blue cohosh Caulophyllum thalictroides (L.) Michx

Phytochemical Analysis

Volumn 9, Issue 5, 1998, Pages 232-236

  Betz, Joseph M ^a   Andrzejewski, Denis ^a   Troy, Annette ^a   Casey, Ryan E ^a,c   Obermeyer, William R ^a   Page, Samuel W ^a   Woldemariam, Tibebe Z ^b,d  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c CLEMSON UNIVERSITY   (United States)

^d Phytera Inc   (United States)

Author keywords

Blue cohosh; Dietary supplements; Gas chromatography; Quinolizidine alkaloids

Indexed keywords

ALKALOIDS; ANIMALS; FOOD ADDITIVES; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; NUTRITION; VITAMINS;

BLUE COHOSH; GAS-CHROMATOGRAPHIC DETERMINATION; NORTH AMERICAN; PREGNANT WOMAN; QUINOLIZIDINE ALKALOIDS;

DIETARY SUPPLEMENTS;

ALKALOID; ANAGYRINE; MAGNOFLORINE; TERATOGENIC AGENT;

ARTICLE; DIET SUPPLEMENTATION; GAS CHROMATOGRAPHY; HERB; MASS SPECTROMETRY;

CAULOPHYLLUM THALICTROIDES;

EID: 0031689684     PISSN: 09580344     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1565(199809/10)9:5<232::AID-PCA412>3.0.CO;2-5     Document Type: Article

References (34)

1. Castleman, M. (1991). The Healing Herbs, pp. 82-84. Rodale Press, Emmaus, Pennsylvania.
2. Chandrasekhar, K. and Sarma, G. H. R. (1974). Observations on the effect of low and high doses of Caulophyllum on the ovaries and the consequential changes in the uterus and thyroid in rats. J. Reprod. Fertil. 38, 236-237.
3. Checke, P. R. and Shull, L. R. (1985). Natural Toxicants in Feeds and Poisonous Plants. AVI Publishing Company, Westport, Conneticutt.
4. El-Tahir, K. E. H. (1991). Pharmacological actions of magnoflorine and aristolochic acid-1 isolated from the seeds of Aristolochia bracteata. Int. J. Pharmac. 29, 101-110.
5. Ferguson, H. C. and Edwards, L. D. (1954). A pharmacological study of a crystalline glycoside of Caulophyllum thalictroides. J. Am. Pharmac. Assoc. 43, 16-23.
6. Finnell, R. H. and Chernoff, G. F. (1988). Anagyrine-induced congenital defects (letter). J. Pediatrics 112, 331.
7. Flom, M. S., Doskotch, R. W. and Beal, J. L (1967). Isolation and characterization of alkaloids from Caulophyllum thalictroides. J. Pharmac. Sci. 56, 1515-1517.
8. Hardin, J. W. and Arena, J. M. (1974). Human Poisoning from Native and Cultivated Plants, 2nd edn. Duke University Press, Durham, North Carolina.
9. Hutchens, A. R. (1992). A Handbook of Native American Herbs. Shambala Publications, Boston, Massachusetts.
10. Keeler, R. F. (1973a). Lupin alkaloids from teratogenic and nonteratogenic lupins. I. Correlations of crooked calf disease incidence with alkaloid distribution determined by gas chromatography. Teratology 7, 23-30.
11. Keeler, R. F. (1973b). Lupin alkaloids from teratogenic and nonteratogenic lupins. II. Identification of the major alkaloids by tandem gas chromatography-mass spectrometry in plants producing crooked calf disease. Teratology 7, 31-36.
12. Keeler, R. F. (1976). Lupin alkaloids from teratogenic and nonteratogenic lupins. III. Identification of anagyrine as a teratogen by feeding trials. J. Toxicol. Environ. Health 1, 887-898.
13. Keeler, R. F. and Baker, D. C. (1990). Myopathy in cattle induced by alkaloid extracts from Thermopsis montana, Laburnum anagyroides and a Lupinus sp. J. Comp. Pathol. 103, 169-182.
14. Keeler, R. F. and Gross, R. (1980). The total alkaloid and anagyrine contents of some bitter and sweet selections of lupin species used as food. J. Environ. Pathol. Toxicol. 3, 333-340.
15. Keeler, R. F. and Panter, K. E. (1989). Piperidine alkaloid composition and relation to crooked calf disease-inducing potential of Lupinus formosus. Teratology 40, 423-432.
16. Keeler, R. F., Cronin, E. H. and Shupe, J. L. (1976). Lupin alkaloids from teratogenic and nonteratogenic lupins. IV. Concentration of total alkaloids, individual major alkaloids, and the teratogen anagyrine as a function of plant part and stage of growth and their relationship to crooked calf disease. J. Toxicol. Environ. Health 1, 899-908.
17. Keeler, R. F., Johnson, A. E. and Chase, R. L. (1986). Toxicity of Thermopsis montana in cattle. Cornell Vet. 76, 115-127.
18. Kilgore, W. W., Crosby, D. G., Craigmill, A. L. and Poppen, N. K. (1981). Toxic plants as possible human teratogens. Calif. Agric. Nov-Dec, 6.
19. Kingsbury, J. M. (1964). Poisonous Plants of the United States and Canada. Prentice-Hall, Englewood Cliffs, New Jersey.
20. Lazerson, J. (1988). Anagyrine-induced congenital defects (Reply). J. Pediatrics 112, 331.
21. McShefferty, J. and Stenlake, J. B. (1956). Caulosapogenin and its identity with hederagenin. J. Chem. Soc. 449, 2314-2316.
22. Meeker, J. E. and Kilgore, W. W. (1987). Identification and quantitation of the alkaloids of Lupinus latifolius. J. Agric. Food Chem. 35, 431-433.
23. Moore, M. L (1949). The Leuckart reaction. In Organic Reactions. (Adams, R., Bachmann, W. E., Blatt, A. H., Fieser, L. F. and Johnson, J. R., eds.), Vol 5, pp. 301-330. Wiley, New York.
24. Ortega, J. A. and Lazerson, J. (1987). Anagyrine-induced red cell aplasia, vascular anomaly, and skeletal dysplasia. J. Pediatrics 111, 87-89.
25. Panter, K. E. and Keeler, R. F. (1993). Quinolizidine and piperidine alkaloid teratogens from poisonous plants and their mechanism of action in animals. Vet. Clin. North Am. Food Anim. Pract. 9, 33-40.
26. Panter, K. E., Keeler, R. F. and Bunch, T. D. (1990). Congenital skeletal malformations and cleft palate induced in goats by ingestion of Lupinus, Conium, and Nicotiana species. Toxicon 28, 1377-1385.
27. Panter, K. E., Gardner, D. R. and Molyneux, R. J. (1994). Comparison of toxic and teratogenic effects of Lupinus formosus, L. arbustus and L. caudatus in goats. J. Nat. Tox. 3, 83-93.
28. Power, F. B. and Salway, A. H. (1913). The Constituents of the rhizome and roots of Caulophyllum thalictroides. J. Chem. Soc. 103, 191-209.
29. Ruiz, L. P. (1978). Alkaloid analysis of "sweet" lupin seed by GLC. New Zealand J. Agric. Res. 21, 241-242.
30. Schmeller, T., Sauerwein, M., Sporer, F., Wink, M. and Mueller, W. E. (1994). Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors. J. Nat. Prod. 57, 1316-1319.
31. Scott, C. C. and Chen, K. K. (1943). The pharmacological action of N-methylcytisine. J. Pharmacol. Exp. Therapeutics 79, 334-339.
32. Shupe, J. L., Binns, W., James, L. F. and Keeler, R. F. (1967). Lupine, a cause of crooked calf disease. J. Am. Vet. Med. Assoc. 151, 198-203.
33. Tyler, V. E. (1993). The Honest Herbal, 3rd edn., pp. 47-48. Pharmaceutical Products Press, Binghamton, New York.
34. Woldemariam, T. Z., Betz, J. M. and Houghton, P. J. (1997). Analysis of aporphine and quinolizidine alkaloids from Caulophyllum thalictroides by densitometry and HPLC. J. Pharmac. Biomed. Anal. 15, 839-843.