Mechanisms of pH preservation during global ischemia in preconditioned rat heart: Roles for PKC and NHE

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 3 44-3, 1998, Pages

  Rehring, Thomas F ^a   Shapiro, Joseph I ^a   Cain, Brian S ^a   Meldrum, Daniel R ^a   Cleveland, Joseph G ^a   Harken, Alden H ^a   Banerjee, Anirban ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

31P nuclear magnetic resonance spectroscopy; Cyclic ischemic preconditioning; Myocardial ischemia; Myocellular acidosis; Phenylephrine; Sodium hydrogen exchange; 1 adrenergic agonist

Indexed keywords

PHENYLEPHRINE; PROTEIN KINASE C;

ANIMAL TISSUE; ARTICLE; CONDITIONING; ENZYME ACTIVATION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; MALE; METABOLIC ACIDOSIS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON SODIUM EXCHANGE; PROTON TRANSPORT; RAT; SIGNAL TRANSDUCTION;

EID: 0031689060     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.3.h805     Document Type: Article

References (18)

1. Albuquerque, C. P. de, G. Gerstenblith, and R. G. Weiss. Myocardial buffering capacity in ischemia preconditioned rat hearts. J. Mol. Cell. Cardiol. 27: 777-781, 1995.
2. Asimakis, G. K. Myocardial glycogen depletion cannot explain the cardioprotective effects of ischemic preconditioning in the rat heart. J. Mol. Cell. Cardiol. 28: 563-570, 1996.
3. Asimakis, G., K. Inners-McBride, G. Medellin, and V. Conti. Ischemic preconditioning attenuates acidosis and postischemic dysfunction in isolated rat heart. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H887-H894, 1992.
4. Banerjee, A., F. Gamboni-Robertson, M. B. Mitchell, T. F. Rehring, K. Butler, J. C. Cleveland, D. R. Meldrum, J. I. Shapiro, and X. Meng. Stress-induced cardioadaptation reveals a code linking hormone receptors and spatial redistribution of PKC isoforms. Ann. NY Acad. Sci. 793: 226-239, 1996.
5. Brooks, G., and D. J. Hearse. Role of protein kinase C in ischemic preconditioning: player or spectator? Circ. Res. 79: 627-630, 1996.
6. Bugge, E., and K. Ytrehus. Inhibition of sodium-hydrogen exchange reduces infarct size in the isolated rat heart-a protective additive to ischaemic preconditioning. Cardiovasc. Res. 29: 269-274, 1995.
7. Chen, W., W. Wetsel, C. Steenbergen, and E. Murphy. Effect of ischemic preconditioning and PKC activation on acidification during ischemia in rat heart. J. Mol. Cell. Cardiol. 28: 871-880, 1996.
8. Cross, H. R., K. Clarke, K. Clarke, and G. Radda. Is lactate-induced myocardial ischemic injury mediated by decreased pH or increased intracellular lactate? J. Mol. Cell. Cardiol. 27: 1369-1381, 1995.
9. Dennis, S. C., W. Gevers, and L. H. Opie. Protons in ischemia: where do they come from; where do they go to? J. Mol. Cell. Cardiol. 23: 1077-1086, 1991.
10. Fliegel, L., and O. Fröhlich. The Na/H exchanger: an update on structure, regulation and cardiac physiology. Biochem. J. 296: 273-285, 1993.
11. Gottlieb, R. A., D. L. Gruol, J. Y. Zhu, and R. L. Engler. Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis. J. Clin. Invest. 97: 2391-2398, 1996.
12. 1b-adrenoreceptors, pertussis toxin-sensitive G proteins, and protein kinase C. Circulation 92: 2259-2265, 1995.
13. Jeffrey, F. M. H., C. J. Storey, and C. R. Malloy. Predicting functional recovery from ischemia in the rat myocardium. Basic Res. Cardiol. 87: 548-558, 1992.
14. Koike, A., T. Akita, Y. Hotta, K. Takeya, I. Kodama, M. Murase, T. Abe, and J. Toyama. Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy. J. Thorac. Cardiovasc. Surg. 112: 765-775, 1996.
15. Meldrum, D. R., J. C. J. Cleveland, X. Meng, B. C. Sheridan, F. Gamboni, B. S. Cain, A. H. Harken, and A. Banerjee. Protein kinase C isoform diversity in preconditioning. J. Surg. Res. 69: 183-187, 1997.
16. Mitchell, M. B., X. Meng, L. Ao, J. M. Brown, A. H. Harken, and A. Banerjee. Preconditioning of isolated rat heart is mediated by protein kinase C. Circ. Res. 76: 73-81, 1995.
17. Murphy, E., W. Glasgow, T. Fralix, and C. Steenbergen. Role of lipoxygenase metabolites in ischemic preconditioning. Circ. Res. 76: 457-467, 1995.
18. Murry, C. E., R. B. Jennings, and K. A. Reimer. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124-1136, 1986.