Neurological outcome in adult patients with early-treated phenylketonuria

European Journal of Pediatrics

Volumn 157, Issue 10, 1998, Pages 824-830

  Pietz, J ^a   Dunckelmann, R ^a   Rupp, A ^a   Rating, D ^a   Meinck, H M ^a   Schmidt, H ^a   Bremer, H J ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Intelligence; Neurology; Neuropsychology; Phenylketonuria

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ATTENTION; BRAIN INJURY; CORRELATION FUNCTION; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MOTOR PERFORMANCE; NEUROLOGIC DISEASE; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENYLKETONURIA; PRIORITY JOURNAL; PROGNOSIS; TREMOR;

ADOLESCENT; ADULT; ATTENTION; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MOTOR SKILLS; NERVOUS SYSTEM DISEASES; NEUROBEHAVIORAL MANIFESTATIONS; NEUROPSYCHOLOGICAL TESTS; PHENYLKETONURIAS;

EID: 0031688522     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004310050945     Document Type: Article

References (31)

1. Anderson VE, Siegel FS, Tellegen A, Fisch RO (1968) Manual dexterity in phenylketonuric children. Percept Mot Skills 26:827-834
2. Azen CG, Koch R, Friedman EG, Berlow St, Coldwell J, Krause W, Matalon R, McCabe E, O'Flynn M, Peterson R, Rouse B, Scott CR, Sigman B, Valle D, Warner R (1991) Intellectual development in twelve-year-old children treated for phenylketonuria. AJDC 145:35-39
3. Burgard P, Schmidt E, Rupp A, Schneider W, Bremer HJ (1996) Intellectual development of the patients of the German Collaborative Study of children treated for phenylketonuria. Eur J Pediatr 155 [Suppl 1]:S33-S38
4. Cleary MA, Walter JH, Jenkins JP, Alani, SM, Tyler K, Whittle D (1994) Magnetic resonance imaging of the brain in phenylketonuria. Lancet 344:87-90
5. Deuschl G, Krack P, Lauk M, Timmer J (1996) Clinical neurophysiology of tremor. J Clin Neurophysiol 13:110-121
6. Epstein CM, Trotter JF, Averbrook A, Freeman S, Kutner MH, Elsas LJ (1989) EEG mean frequencies are sensitive indices of phenylalanine effects on normal brain. Electroencephalogr Clin Neurophysiol 72:133-139
7. Findley LJ (1996) Classification of tremors. J Clin Neurophysiol 13:122-132
8. Flynn JR (1987) Massive IQ gains in 14 nations: what IQ tests really measure. Psychol Bull 101:171-191
9. Giovannini M, Agostini C, Biasucci G, Rottoli A, Luotti D, Trojan S, Riva E (1996) Fatty acid metabolism in phenylketonuria. Eur J Pediatr 155 [Suppl 1]:S132-S135
10. Griffith P, Paterson L, Harvie A (1995) Neuropsychological effects of subsequent exposure to phenylalanine in adolescents and young adults with early-treated phenylketonuria. J Intellect Disabil Res 39:365-372
11. 12 deficiency in adolescents and young adults with phenylketonuria. Lancet 342:997
12. Holtzman NA, Welcher DW, Mellits ED (1975) Termination of restricted diet in children with phenylketonuria: a randomized controlled study. N Engl J Med 293:1121-1124
13. Holtzman NA, Kronmal RA, Van Doornick W, Azen C, Koch R (1986) Effect of age at loss of dietary control on intellectual performance and behavior of children with phenylketonuria. N Engl J Med 293:1121-1124
14. Jöreskog K, Sörbom D (1993) LISREL8: structural equation modeling with the SIMPLIS command language. Scientific Software International, Chicago, USA
15. Michel U, Schmidt E, Batzler U (1990) Results of psychological testing of patients aged 3-6 years. Eur J Pediatr 149 [Suppl 1]:S34-S35
16. Krause W, Halminski M, McDonald L, Dembure Ph. Salvo R, Freides D, Elsas L (1985) Biochemical and neuropsychological effects of elevated plasma phenylalanine in patients with treated phenylketonuria. J Clin Invest 75:40-48
17. Opp J, Wenzel D, Brandl U (1992) Visuomotor coordination during focal and generalized EEG discharges. Epilepsia 33:836-840
18. Pedersen HE, Birket-Smith E (1974) Neurological abnormalities in phenylketonuria. Acta Neurol Scand 50:589-598
19. Pietz J, Schmidt E, Matthis P, Kobialka B, Kutscha A, Sonneville LMJ de (1993) EEGs in phenylketonuria. I: Follow-up to adulthood, II: Shortterm diet-related changes in EEGs and cognitive function. Dev Med Child Neurol 35:54-64
20. 1H MR spectroscopy of the brain in patients with early-treated phenylketonuria. Radiology 201:413-420
21. Pietz J, Fätkenheuer B, Burgard P, Armbruster M, Esser G, Schmidt H (1997) Psychiatric disorders in adult patients with early-treated phenylketonuria. Pediatrics 99:345-350
22. Schmidt E, Rupp A, Burgard P, Pietz J, Weglage J, De Sonneville LMJ (1994) Sustained attention in adult phenylketonuria: the influence of the concurrent phenylalanine-blood-level. J Clin Exp Neuropsychol 16:681-688
23. Schoppe KJ (1974) Das MLS-Gerät: ein neuer Testapparat zur Messung feinmotorischer Leistungen. Diagnostica XX 1:43-46
24. Schulz B, Bremer HJ (1995) Nutrient intake and food consumption of adolescents and young adults with phenylketonuria. Acta Pediatr 84:743-748
25. Smith I, Beasley MG, Ades AE (1990) Effect on intelligence of relaxing the low phenylalanine diet in phenylketonuria. Arch Dis Child 65:311-316
26. Steinhausen HC (1974) Psychological evaluation of treatment in phenylketonuria: intellectual, motor and social development. Neuropädiatrie 5:146-156
27. Thompson AJ, Smith I, Brenton D, Youl BD, Rylance G, Davidson DC, Kendall B, Lees AJ (1990) Neurological deterioration in young adults with phenylketonuria. Lancet 336:602-605
28. Thompson AJ, Tillotson AJ, Smith I, Kendall B, Moore SG, Brenton DP (1993) Brain MRI changes in phenylketonuria. Associations with dietary status. Brain 116:811-821
29. Villasana D, Butler IJ, Williams JC, Roongta SM (1989) Neurological deterioration in adult phenylketonuria. J Inherit Metab Dis 12:451-457
30. Waisbren SE, Mahon BE, Schnell RR, Levy HL (1987) Predictors of intelligence quotient and intelligence quotient change in persons treated for phenylketonuria. Pediatrics 79:351-355
31. Weglage J, Pietsch M, Fünders B, Koch HG, Ullrich K (1995) Neurological findings in early treated phenylketonuria. Acta Paediatr 84:411-415