Pharmacokinetic study in dogs and monkeys after single intravenous and oral administrations of [14C]-ITF-296

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 2, 1998, Pages 239-250

  Giachetti, C ^a   Bertolino, M ^a   Canali, S ^a   Lombardini, E ^a   Monzani, M V ^b   Sala, A ^b   Zanolo, G ^a  

^a Istituto di Ricerche Biomediche Antoine Marxer SpA   (Italy)

^b Italfarmaco SpA   (Italy)

Author keywords

Dog; Excretion balance; ITF 296; Monkey; Pharmacokinetics; Plasma

Indexed keywords

3 (2 HYDROXYETHYL) 2H 1,3 BENZOXAZIN 4(3H) ONE; CARBON 14; DRUG METABOLITE; ITF 1577; SINITRODIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; CONFERENCE PAPER; DOG; DRUG ABSORPTION; DRUG DETERMINATION; DRUG ELIMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; MALE; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; RADIOACTIVITY; URINARY EXCRETION;

EID: 0031687606     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03189346     Document Type: Conference Paper

References (9)

1. Abrams J. (1985): Haemodynamic effects of nitroglycerin and long-acting nitrates. Am. Hearth J., 110, 214-216
2. Parker J.O. (1987): Nitrate therapy in stable angina pectoris. N. Eng. J. Med., 316, 1635-1642
3. Conti C.R. (1987): Use of nitrates in unstable angina pectoris. Am. J. Cardiol., 60, 31H-34H
4. Williams D.O., Amsterdam E.A. and Mason D.T. (1975): Haemodynamic effects of nitroglycerin in acute myocardial infarction: decrease in ventricular preload at the expense of cardiac output. Circulation, 51, 421-427
5. Benedini F., Bertolini G., Cereda R., Donà G., Gromo G., Levi S., Mizrahi J. and Sala A. (1995): New antianginal nitro esters with reduced hypotensive activity. Synthesis and pharmacological evaluation of 3-[(nitrooxy)alkyl]-2H1,3-benzoxazin-4-(3H)-ones. J. Med. Chem., 38, 130-136
6. Italfarmaco Research Center (1995): Pharmacologic properties of the new nitric oxide donor ITF 296. J. Cardiovas. Pharmacol., 26 (Suppl.4), S1-S90
7. Monzani M.V., Coltro G., Jiritano L. and Sala A. (1995): Pharmacokinetic profile of ITF 296 in rats and dogs. J. Cardiovas. Pharmacol., 26 (Suppl.4), S67-S71
8. Monzani M.V. : Pharmacokinetic profile of ITF 296 in monkeys. Unpublished results
9. Monzani M.V., Coltro G., Jiritano L. and Sala A. (1996): Simultaneous determination of ITF 296 and two metabolites in plasma by a validated HPLC method. Boll. Chim. Farm., in press.