Targeting of saporin to Hodgkin's lymphoma cells by anti-CD30 and anti- CD25 bispecific antibodies

British Journal of Haematology

Volumn 102, Issue 4, 1998, Pages 1061-1068

  Sforzini, Sabrina ^a   De Totero, Daniela ^a   Gaggero, Alessia ^a   Ippoliti, Rodolfo ^e   Glennie, Martin J ^c   Canevari, Silvana ^d   Stein, Harald ^b   Ferrini, Silvano ^a,f  

^a CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f UNIVERSITY OF GENOA   (Italy)

Author keywords

Bispecific monoclonal antibodies; CD25; CD30; Hodgkin's lymphoma; Saporin

Indexed keywords

CD30 ANTIGEN; IMMUNOTOXIN; INTERLEUKIN 2 RECEPTOR; MONOCLONAL ANTIBODY; SAPORIN;

ANTIBODY SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG DELIVERY SYSTEM; FLOW CYTOMETRY; HODGKIN DISEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIBODIES, BISPECIFIC; ANTIGENS, CD30; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; HODGKIN DISEASE; HUMANS; HYBRIDOMAS; IMMUNOTOXINS; N-GLYCOSYL HYDROLASES; NEOPLASM PROTEINS; PLANT PROTEINS; RECEPTORS, INTERLEUKIN-2; TUMOR CELLS, CULTURED;

EID: 0031687444     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00859.x     Document Type: Article

References (34)

1. Amlot, P.L., Stone, M.J., Cunningham, D., Fay, J., Newman, J., Collins, R., May, R., McCarth, M., Richardson, J., Ghetie, V., Ramilo, O., Thorpe, P.E., Uhr, J.W. & Vitetta, E.S. (1993) A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy. Blood, 82, 2624-2633.
2. Barbieri, L., Battelli, M.G. & Stirpe, F. (1993) Ribosome-inactivating proteins from plants. Biochimica et Biophysica Acta, 1154, 237-282.
3. Barbieri, L., Stoppa, C. & Bolognesi, A. (1987) Large-scale chromatographic purification of ribosome-inactivating proteins. Journal of Chromatography, 408, 235-243.
4. Bolognesi, A., Tazzari, P.L., Tassi, C., Gromo, G., Gobbi, M. & Stirpe, F. (1992) A comparison of anti-lymphocyte immunotoxins containing different ribosome-inactivating proteins and antibodies. Clinical and Experimental Immunology, 89, 341-346.
5. Bonardi, M.A., Bell, A., French, R.R., Gromo, G., Hamblin, T., Modena, M. Tutt, A.L. & Glennie, M.J. (1992) Initial experience in treating human lymphoma with a combination of bispecific antibody and saporin. International Journal of Cancer, 7, (Suppl.). 73-77.
6. Bonardi, M.A., French, R.R., Amlot, P., Gromo, G., Modena, D. & Glennie, M.J. (1993) Delivery of saporin to human B cell lymphoma using bispecific antibody: targeting via CD22 but not CD19, CD37 or immunoglobulin results in efficient killing. Cancer Research, 53, 3015-3021.
7. Cambiaggi, A., Cantoni, C., Marciano, S., De Totero, D., Pileri, S., Tazzari, P.L., Stein, H. & Ferrini, S. (1993) Cultured human NK cells express the Ki-1/CD30 antigen. British Journal of Haematology. 85, 270-276.
8. Casalini, P., Mezzanzanica, D., Canevari, S., Della Torre, G., Miotti, S., Colnaghi, M.I. & Matzku, S. (1991) Use of combination of monoclonal antibodies directed against three distinct epitopes of a tumour-associated antigen: analysis of cell binding and internalization. International Journal of Cancer, 48, 284-290.
9. Durkop, H., Latza, U., Hummel, M., Eltelbach, F., Seed, B. & Stein, H. (1992) Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. Cell, 68, 1-20.
10. Engert, A., Burrows, S., Jung, W., Tazzari, P.L., Stein, H., Pfreundschuh, M. Diehl, V. & Thorpe, P. (1990) Evaluation of ricin A chain-containing immunotoxins directed against the CD30 antigen as potential reagents for the treatment of Hodgkin's disease. Cancer Research, 50, 84-88.
11. Engert, A., Diehl, V., Schnell, R., Radszuhun, A., Hatwig, M., Drillich, S., Schon, G., Bohlen, H., Tesch, H., Hansmann, M., Barth, S., Schindler, J., Ghetie, V., Uhr, J. & Vitetta, E. (1997) A phase-I study of an anti-CD25 RicinA-chain immunotoxin (RFT5-SMPT-dgA) in patients with refractory Hodgkin's lymphoma. Blood, 2, 403-410.
12. Engert, A., Gottstein, C., Bohlen, H., Winkler, U., Schon, G., Manske, O., Schnell, R., Diehl, V. & Thorpe, P. (1995) Cocktails of ricin A-chain immunotoxins against different antigens on Hodgkin and Sternberg-Reed cells in vitro and solid Hodgkin tumors in mice. International Journal of Cancer, 63, 304-309.
13. Falini, B., Bolognesi, A., Flenghi, L., Tazzari, P.L., Broe, M.K., Stein, H., Durkop, H., Aversa, F., Corneli, P., Pizzolo, G., Barbabietola, G., Sabattini, E., Pileri, S., Martelli, M.F. & Stirpe, F. (1992) Response of refractory Hodgkin's disease to therapy with anti-CD30 monoclonal antibody linked to saporin (BER-H2/SO6) immunotoxin. Lancet, 339, 1195-1196.
14. Flavell, D.J., Cooper, S., Morland, B., French, R. & Flavell, S.U. (1992) Effectiveness of combinations of bispecific antibodies for delivering saporin to human acute T cell lymphoblastic leukaemia cell lines via CD7 and CD38 as cellular target molecules. British Journal of Cancer, 65, 545-551.
15. French, R.R., Courtenay, A.K., Ingamells, S., Stevenson, G.T. & Glennie, M.J. (1991) Cooperative mixtures of bispecific F(ab′) antibodies for delivering saporin to lymphoma in vitro and in vivo. Cancer Research, 51, 2353.
16. French, R.R., Hamblin, T.J., Bell, A.J., Tutt, A.L. & Glennie, M.J. (1995) Treatment of B-cell lymphomas with combination of bispecific antibodies and saporin. Lancet, 346, 223-224.
17. 2 antibody for the delivery of saporin in the treatment of lymphoma. Journal of Immunology, 141, 3662-3670.
18. Milstein, C. & Cuello, A.C. (1984) Hybrid hybridomas and the production of bispecific monoclonal antibodies. Immunology Today, 5, 299-304.
19. Minami, J. & Taniguchi, T. (1995) IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor. Current Opinion in Cell Biology, 7, 156-162.
20. + anaplastic large cell lymphoma. Blood, 85, 2139-2146.
21. Peltier, P., Curtet, C., Chatal, J.F., Le Doussal, J.M., Daniel, G., Aillet, G., Gruaz-Guyon, A., Barbet, J. & Gatter, K.C. (1993) Radioimmunodetection of medullary thyroid cancer using a bispecific anti-CEA/anti-indium-DTPA antibody and an indium-111-labeled DTPA dimer. Journal of Nuclear Medicine, 34, 1267-1273.
22. Schwarting, R., Gerdes, J., Durkop, H., Falini, B., Pileri, S. & Stein, H. (1989) BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. Blood, 74, 1678-1689.
23. + neoplastic cells to gelonin delivered by anti-CD30/anti-gelonin bispecific antibodies. British Journal of Haematology, 90, 572-577.
24. + hematologic neoplasias by bispecific antibodies. Journal of Hematotherapy, 4, 429-432.
25. Stein, H., Gerdes, J., Schwab, U., Lemke, H., Mason, D.Y., Ziegler, A., Schienle, W. & Diehl, V. (1982) Identification of Hodgkin and Sternberg-Reed cells as a unique cell type derived from a newly detected small cell population. International Journal of Cancer, 30, 445-459.
26. Stein, H., Mason, D.Y., Gerdes, J., O'Connor, N., Wainscoat, J., Pallesen, G., Gatter, K., Falini, B., Delsol, G., Lemke, H., Schwarting, R. & Lennert, K. (1985) The expression of the Hodgkin's disease-associated antigen Ki-1 in reactive and neoplastic tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood, 66, 848-858.
27. Stirpe, F., Gasperi-Campani, A., Barbieri, L., Falasca, A., Abbondanza, A. & Stevens, W.A. (1983) Ribosome-inactivating proteins from the seeds of Saponaria of officinalis (soapwort), of Agrosthemma githago L (corn cockle) and Asparagus officinalis L, and from the latex of Hura crepitans L (sandbox tree). Biochemical Journal, 216, 617-625.
28. Strocchi, P., Barbieri, L. & Stirpe, F. (1992) Immunological properties of ribosome-inactivating proteins and of a saporin-IgG conjugate. Journal of Immunological Methods, 155, 57-63.
29. Takeshita, T., Asao, H., Ohtani, K., Ishii, N., Kumaki, S., Tanaka, N., Munakata, H., Nakamura, N. & Sugamura, K. (1992) Cloning of the γ chain of the human IL-2 receptor. Science, 257, 379-382.
30. + lymphoma: in vitro evaluation. British Journal of Haematology, 81, 203-211.
31. Tazzari, P.L. Zhang, S., Chen, Q., Sforzini, S., Bolognesi, A., Stirpe, F., Xie, H., Moretta, A. & Ferrini, S. (1995) Targeting of saporin to CD25-positive normal and neoplastic lymphocytes by an anti-saporin/anti-CD25 bispecific monoclonal antibody: in vitro evaluation. British Journal of Cancer, 67, 1248-1253.
32. Thorpe, P.E., Wallace, P.M., Knowles, P.P., Relf, M.G., Brown, A.N.F., Watson, G.J., Blakey, D.C. & Newell, D.R. (1988) Improved anti-tumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages. Cancer Research, 48, 6396-6403.
33. Vitetta, E.S., Stone, M., Amlot, P., Fay, J., May, R., Till, M., Newman, J., Clark, P., Collins, R., Cunningham, D., Ghetie, V., Uhr, J.W. & Thorpe, P.E. (1991) A phase I immunotoxin trial in patients with B cell lymphoma. Cancer Research, 51, 4052-4058.
34. Vitetta, E.S., Thorpe, P.E. & Uhr, J.W. (1993) Immunotoxins: magic bullets or misguided missiles? Immunology Today, 14, 252-259.