Vascular control of nutrient delivery by flow redistribution within muscle: Implications for exercise and post-exercise muscle metabolism

International Journal of Sports Medicine

Volumn 19, Issue 6, 1998, Pages 391-400

  Clark, M G ^a,b   Rattigan, S ^a   Newman, J M B ^a   Eldershaw, T P D ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b Division of Biochemistry   (Australia)

Author keywords

Insulin; Non nutritive flow; Nutritive flow; Sympathetic control of flow; Tendon and septa flow; Vasoconstrictors; Vasodilators

Indexed keywords

ARTICLE; BIOAVAILABILITY; CAPILLARY FLOW; EXERCISE; HUMAN; MUSCLE BLOOD FLOW; MUSCLE CONTRACTION; MUSCLE FUNCTION; MUSCLE METABOLISM; NUTRIENT; SKELETAL MUSCLE;

CAPILLARIES; CAPILLARY PERMEABILITY; ENERGY METABOLISM; EXERTION; HUMANS; MICROCIRCULATION; MUSCLE CONTRACTION; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; REGIONAL BLOOD FLOW; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0031686555     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-971935     Document Type: Article

References (70)

1. Barclay JH. A delivery-independent blood flow effect on skeletal muscle fatigue. J Appl Physiol 1986; 61: 1084-90
2. Barclay JK, Stainsby WN. The role of blood flow in limiting maximal metabolic rate in muscle. Med Sci Sports 1975; 7: 116-9
3. Barcroft H. Circulation in skeletal muscle. In: Hamilton WF, Dow Ph. (editors): Handbook of Physiology. New York: Amer Phys Soc 1963; II, Part 2: 1353-8
4. Barlow C, Ewen J, Glenny R, Kelly J. Microsphere imaging system. Seatle, USA, Abstract Third Intl. Conf. Fluorescent Microsphere Methods. 1996
5. Barlow TE. Vascular patterns in the alimentory canal. In: Wolstenholme GEW (editor): Visceral Circulation. Ciba Foundation Symposium. London, Churchill 1952: 21-31
6. Barlow TE, Haigh AL, Walder DN. A search for arteriovenous anastomoses in skeletal muscle. J Physiol (Lond) 1958; 143: 80-1P
7. Barlow TE, Haigh AL, Walder DN. Dual circulation in skeletal muscle. J Physiol (Lond) 1959; 149: 18-9P
8. Barlow TE, Haigh AL, Walder DN. Evidence for two vascular pathways in skeletal muscle. Clin Sci 1961; 20: 367-85
9. Borgström P, Bruttig SP, Lindbom L, Intaglietta M, Arfors K-E. Microvascular responses in rabbit skeletal muscle after fixed volume hermorrhage. Am J Physiol 1990; 259: H190-6
10. Borgström P, Lindbom L, Arfors K-E, Intaglietta M. β-Adrenergic control of resistance in individual vessels in rabbit tenuissimus muscle. Am J Physiol 1988; 254: H631-5
11. Boyd JD. General survey of visceral vascular structure. In: Visceral Circulation. Wolstenholme GEW (editor): Ciba Foundation Symposium. London, Churchill 1952: 3-11
12. Cerretelli P, Marconi C, Pendergast D, Meyer M, Heisler N, Piiper J. Blood flow in exercising muscles by xenon clearance and by microsphere trapping. J Appl Physiol 1984; 56: 24-30
13. Clark MG, Colquhoun EQ, Dora KA, Rattigan S, Eldershaw TPD, Hall JL, Matthias Y, Ye JM. Resting muscle. A source of thermogenesis controlled by vasomodulators. In: Milton AS (editor). Temperature Regulation: Recent physiological and pharmacological advances. Basel: Birkhäuser Verlag, 1994: 315-20
14. Clark MG, Colquhoun EQ, Rattigan S, Dora KA, Eldershaw TPD, Hall JL, Ye JM. Vascular and endocrine control of muscle metabolism. Am J Physiol 1995; 268: E797-812
15. Clark MG, Rattigan S, Dora KA, Newman JMB, Steen JT, Miller KA, Vincent MA. Vascular and metabolic regulation of muscle. In: Kinney JM, Tucker H. editors. Physiology, Stress and Malnutrition. New York: Lippincott-Raven, 1997: 325-46
16. Clark MG, Richards SM, Hettiarachchi M, Ye JM, Appleby GJ, Rattigan S, Colquhoun EQ. Release of purine and pyrimidine nucleosides and their catabolites from the perfused rat hindlimb in response to noradrenaline, vasopressin, angiotensin II and sciatic-nerve stimulation. Biochem J 1990; 266: 765-70
17. Colquhoun EQ, Hettiarachchi M, Ye JM, Rattigan S, Clark MG. Inhibition by vasodilators of noradrenaline and vasoconstrictor-mediated, but not skeletal muscle contraction-induced oxygen uptake in the perfused rat hindlimb; implications for non-shivering thermogenesis in muscle tissue. Gen Pharamac 1990; 21: 141-8
18. Colquhoun EQ, Hettiarachchi M, Ye JM, Richter EA, Hniat AJ, Rattigan S, Clark MG. Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb. Life Sci 1988; 43: 1747-54
19. Dora KA, Colquhoun EQ, Hettiarachchi M, Rattigan S, Clark MG. The apparent absence of serotonin-mediated vascular thermogenesis in perfused rat hindlimb may result from vascular shunting. Life Sci 1991; 48: 1555-64
20. Dora KA, Rattigan S, Colquhoun EQ, Clark MG. Aerobic muscle contraction impaired by serotonin-mediated vasoconstriction. J Appl Physiol 1994; 77: 277-84
21. Dora KA, Richards SM, Rattigan S, Colquhoun EQ, Clark MG. Serotonin and norepinephrine vasoconstriction in rat hindlimb have different oxygen requirements. Am J Physiol 1992; 262: H698-703
22. Durán WN, Renkin EM. Oxygen consumption and blood flow in resting mammalian skeletal muscle. Am J Physiol 1974; 226: 173-7
23. Eriksson E, Myrhage R. Microvascular dimensions and blood flow in skeletal muscle. Acta Physiol Scand 1972; 86: 211-22
24. 2, tension, and vascular resistance in contracting canine skeletal muscle. J Appl Physiol 1988; 65: 1075-81
25. Grant RT. Direct observation of skeletal muscle blood vessels (rat cremaster). J Physiol (Lond) 1964; 172: 123-37
26. Grant RT, Payling Wright H. Anatomical basis for non-nutritive circulation in skeletal muscle exemplified by blood vessels of rat biceps femoris tendon. J Anat 1970; 106: 125-33
27. Groom AC, Ellis CG, Wrigley SM, Potter RF. Architecture and flow pattern in capillary networks of skeletal muscle in frog and rat. In: Popel AS, Johnson PC (editors): Microvascular Networks: Experimental and Theoretical Studies. Basel: Karger, 1986: 61-76
28. a-adrenoceptors. Am J Physiol 1997; 272: H2146-53
29. Hammersen F. The terminal vascular bed in skeletal muscle with special regard to the problem of shunts. In: Crone C, Lassen NA (editors): Capillary Permeability: the Transfer of Molecules and Ions Between Capillary Blood and Tissue. Copenhagen, Denmark: Munksgaard 1970: 351-65
30. Harrison DK, Birkenhake S, Kauf SK, Kessler M. Local oxygen supply and blood regulation in contracting muscle in dogs and rabbits. J Physiol 1990; 422: 227-43
31. Hettiarachchi M, Parsons KM, Richards SM, Dora KA, Rattigan S, Clark MG. Vasoconstrictor-mediated release of lactate from the perfused rat hindlimb. J Appl Physiol 1992; 73: 2544-51
32. Hirvonen L, Korobkin M, Sonnenschein RR, Wright DL Depression of contractile force of skeletal muscle by intra-arterial vasodilator drugs. Circ Res 1964; 14: 525-35
33. Hirvonen L, Sonnenschein RR. Relation between blood flow and contraction force in active skeletal muscle. Circ Res 1962; 10: 94-104
34. Hudickà O. Basic mechanisms regulating muscle blood flow. In: Muscle Blood Flow: Its relation to muscle metabolism and function. Amsterdam: Sweets & Zeitlinger B. V., 1973: 29-54
35. Hyman C. Essai sur la physiologie de la double circulation dans le muscle. Angéologie 1957; 9: 25-7
36. 133Xe clearance and a direct recording technique. Acta Physiol Scand 1967; 69: 69-78
37. Kobzik L, Reld MB, Brodt DS, Stamler JS. Nitric oxide in skeletal. Nature 1994; 372: 546-8
38. e Congrès Internat. d'Angéiologie, Fribourg 1955: 429-33
39. Lindbom L, Arfors K-E. Non-homogenous blood distribution in the rabbit tenuissimus muscle. Acta Physiol Scand 1984; 122: 225-33
40. Lindbom L, Arfors K-E. Mechanisms and site of control for variation in the number of perfused capillaries in skeletal muscle. Int J Microcirc: Clin Exp 1985; 4: 19-30
41. Mulvany MJ, Aalkjaer C. Structure and function of small arteries. Physiol Rev 1990; 70: 921-61
42. Myrhage R, Eriksson E. Vasculature arrangement in hindlimb muscles of the cat. J Anat 1980; 131: 1-17
43. Newman JMB, Dora KA, Rattigan S, Edwards SJ, Colquhoun EQ, Clark MG. Norepinephrine and serotonin vasoconstriction in rat hindlimb control different vascular flow routes. Am J Physiol 1996; 270: E689-99
44. Newman JMB, Steen JT, Clark MG. Vessels supplying septa and tendons as functional shunts in perfused rat hindlimb. Microvasc Res 1997; 54: 49-57
45. Pappenheimer JR. Vasoconstriction nerves and oxygen consumption in the isolated perfused hindlimb muscles of the dog. J Physiol 1941; 99: 182-200
46. Piiper J. Mechanisms of functional shunting in mammalian skeletal muscle. In: Johansen K, Burggren WW (eds): Cardiovascular Shunts. Copenhagen: Munksgaard, 1985: 467-85
47. Piiper J. Oxygen supply to exercising muscle: roles of diffusion limitation and heterogeneity of blood flow. Adv Exp Med Biol 1994; 361: 503-7
48. Piiper J, Meyer M. Diffusion-perfusion relationships in skeletal muscle: models and experimental evidence from inert gas washout. Adv Exp Med Biol 1984; 169: 457-66
49. Piiper J, Rosell S. Attempt to demonstrate large arteriovenous shunts in skeletal muscle during stimulation of sympathetic vasodilator nerves. Acta Physiol Scand 1961; 53: 214-7
50. Potter RF, Groom AC. Capillary diameter and geometry in cardiac and skeletal muscle studied by means of corrosion casts. Microvasc Res 1983; 25: 68-84
51. Rattigan S, Appleby GJ, Miller KA, Steen JT, Dora KA, Colquhoun EQ, Clark MG. Serotonin inhibition of 1-methylxanthine metabolism parallels its vasoconstrictor activity and inhibition of oxygen uptake in perfused rat hindlimb. Acta Physiol Scand 1997; 161: 161-9
52. Rattigan S, Dora KA, Colquhoun EQ, Clark MG. Serotonin-mediated acute insulin resistance in the perfused rat hindlimb but not in incubated muscle: a role for the vascular system. Life Sci 1993; 53: 1545-55
53. Rattigan S, Dora KA, Colquhoun EQ, Clark MG. Inhibition of insulin-mediated glucose uptake in rat hindlimb by an α-adrenergic vascular effect. Am J Physiol 1995; 268: E305-11
54. Rattigan S, Dora KA, Tong ACY, Clark MG. Perfused skeletal muscle contraction and metabolism improved by angiotensin II mediated vasoconstriction. Am J Physiol 1996; 271: E96-E103
55. Renkin EM. Exchange of substances through capillary walls. In: Wolstenholme GEW, Knight J (editors): Circulatory and Respiratory Mass Transport. Boston: Little, Brown and Co., 1969: 50-66
56. Renkin EM, Rosell S. Effects of different types of vasodilator mechanisms on vascular tonus and on transcapillary exchange of diffusible material in skeletal muscle. Acta Physiol Scand 1962; 54: 241-51
57. Rosell S, Uvnäs B. Vasomotor control of oxygen consumption in skeletal muscle. Acta Physiol Scand 1960; 50 (Suppl. 175): 129-30
58. Saunders RL, Lawrence EJ, Maciner DA, Nemethy N. The anatomic basis of the peripheral circulation in man. On the concept of the macromesh and micromesh as illustrated by the blood supply in man. In: Redish L, Tangeo F, Saunders Ch (editors): Peripheral Circulation in Health and Disease, New York: Grune and Stratton, 1957: 132-7
59. Segal SS, Convection, diffusion and mitochondrial utilization of oxygen during exercise. In: Lamb DR, Gisolfi CV (editors): Energy Metabolism in Exercise and Sport, Perspectives in Exercise Science and Sports Medicine. Vol. 5, Chapt. 7. Dubuque, IA: Brown Benchmark 1992: 269-344
60. Sejrsen P, Tonnesen KH. Inert gas diffusion method for measurement of blood flow using saturation techniques. Circ Res 1968; 22: 679-93
61. Sparks HV, Mohrman DE. Heterogeneity of flow as an explanation of the multiexponential washout of inert gas from skeletal muscle. Microvasc Res 1977; 13: 181-4
62. Stainsby WN, Renkin EM. Autoregulation of blood flow in resting skeletal muscle. Am J Physiol 1961; 201: 117-22
63. Tooke JE. The regulation of microvascular function in diabetes mellitus. In: Pickup J, Williams G (editors): Textbook of Diabetes. Blackwell Scientific Publications 1991: 546-53
64. Tsai AG, Lindbom L, Arfors K-E, Intaglietta M. The effect of vasomotion on exchange in the microvascular network. In: Popel AS, Johnson PC (editors): Microvascular Networks: Experimental and Theoretical Studies. Sym. 1. Tucson, Arizona. Basel: Karger 1985: 99-111
65. Tyml K. Red cell perfusion in skeletal muscle at rest and after mild and severe contrations. Am J Physiol 1987; 252: H485-93
66. Walder DN. The local clearance of radioactive sodium from muscle in normal subjects and those with peripheral vascular disease. Clin Sci 1953; 12: 153-65
67. Walder DN. The relationship between blood flow, capillary surface area and sodium clearance in muscle. Clin Sci 1955; 14: 303-15
68. Wyeth RP, Temma K, Seifen E, Kennedy RH. Negative inotropic actions of nitric oxide requires higher doses in rat cardiac muscle. Pflugers Arch 1996; 432: 678-84
69. Ye JM, Colquhoun EQ, Hettiarachchi M, Clark MG. Flow-induced oxygen uptake by the perfused rat hindlimbs is inhibited by vasodilators and augmented by norepinephrine: a possible role for the microvasculature in hindlimb thermogenesis. Can J Physiol Pharmacol 1990; 68: 119-25
70. Zweifach BW, Metz DB. Selective distribution of blood through the terminal vascular bed of mesenteric structures and skeletal muscle. Angiology 1955; 6: 282-90