Regional blood flow in conscious rats after head-down suspension

European Journal of Applied Physiology and Occupational Physiology

Volumn 78, Issue 4, 1998, Pages 296-302

  Somody, L ^a   Fagette, S ^a   Blanc, S ^a   Frutoso, J ^a   Gharib, C ^a   Gauquelin Koch, G ^a,b  

^a UNIVERSITÉ LYON 1   (France)

^b CNES   (France)

Author keywords

Cardiovascular deconditioning; Conscious rat; Head down suspension; Microspheres; Regional blood flow

Indexed keywords

COBALT 57;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; BRAIN BLOOD FLOW; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; FORELIMB; HEAD TILTING; HEART INDEX; HEART OUTPUT; HEART RATE; HINDLIMB; MALE; MEAN ARTERIAL PRESSURE; MICROGRAVITY; MUSCLE BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR RESISTANCE; VISCERA;

ANIMALS; BLOOD PRESSURE; CARDIAC OUTPUT; CEREBROVASCULAR CIRCULATION; CONDITIONING (PSYCHOLOGY); CONSCIOUSNESS; HEAD-DOWN TILT; HEART RATE; MALE; MICROSPHERES; MUSCLE, SKELETAL; ORGAN SIZE; POSTURE; RATS; RATS, WISTAR; RENIN; WEIGHTLESSNESS SIMULATION;

EID: 0031686318     PISSN: 03015548     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004210050423     Document Type: Article

References (34)

1. Arbeille Ph, Gauquelin G, Pottier JM, Pourcelot L, Guell A, Gharib C (1992) Results of a 4-week head down tilt with and without LBNP countermeasure:II. Cardiac and peripheral hemodynamics-comparison with a 25-day spaceflight. Aviat Space Environ Med 63:9-13
2. Arbeille Ph, Fomina G, Achaibou F, Pottier J, Kotovskaya A (1995) Cardiac and vascular adaptation to 0 g with and without thigh cuffs (Antares 14 and Altair 21 day Mir spaceflights). Acta Astron 36:753-762
3. Barbee RW, Perry BD, Re RN, Murgo JP (1992) Microsphere and dilution techniques for the determination of blood flows and volumes in conscious mice. Am J Physiol 263:R728-R733
4. Blomqvist CG (1996) Regulation of the systemic circulation at microgravity and during readaptation to 1G. Med Sci Sports Exerc 28:9-13
5. Blomqvist CG, Stone HL (1983) Cardiovascular adjustments to gravitational stress. In: Shepard JT, Abboud FM (ed) Handbook of physiology, section 2. The cardiovascular system, vol. III, 2. American Physiological Society, Oxford University Press, New York, pp 1025-1063
6. Bouzeghrane F, Fagette S, Somody L, Allevard AM, Gharib C, Gauquelin G (1996) Restraint vs hindlimb suspension on fluid and electrolyte balance in rats. J Appl Physiol 80:1993-2001
7. Brizzee BL, Walker BR (1990) Altered baroreflex function after tail suspension in the conscious rat. J Appl Physiol 69:2091-2096
8. Convertino VA (1996) Exercise and adaptation to microgravity environments. In: Fregly MJ, Blatteis CM (ed) Handbook of physiology, section 4. Environmental physiology, vol. II, chapter 36. American Physiological Society, Oxford University Press, New York, pp 815-843
9. Convertino VA, Doerr DF, Eckberg DL, Fritsch JM, Vernikos-Daniellis J (1990) Head-down bed-rest impairs vagal baroreflex responses and provokes orthostatic hypotension. J Appl Physiol 68:1458-1464
10. Desplanches D, Mayet MH, Sempore B, Flandrois R (1987) Structural and functional responses to prolonged hindlimb suspension in rat muscle. J Appl Physiol 63:558-563
11. Fagette S, Lo M, Gharib C, Gauquelin G (1995a) Cardiovascular variability and baroreceptor reflex sensitivity over a 14 day-tail suspension in rats. J Appl Physiol 78:717-724
12. Fagette S, Somody L, Bouzeghrane F, Cottet-Emard JM, Gharib C, Gauquelin G (1995b) Effects of recovery after a 14-day tail suspension on central and peripheral sympathetic activity in rats. J Appl Physiol 79:1991-1997
13. Fitts RH, Metzger JM, Riley DA, Unsworth BR (1986) Models of disuse: a comparison of hindlimb suspension and immobilization. J Appl Physiol 60:1946-1953
14. Gharib C, Maurice M, Geelen G, Gauquelin G, Vincent M, Pottier JM, Mehier H, Roussel B, Guell A, Bes A (1988) Volume regulating hormones during weightlessness and simulated weightlessness. In: Boccalon H (ed) Angiologie. Libbey Eurotext, Paris, pp 657-667
15. Hargens AR, Steskal J, Johansson C, Tipton CM (1984) Tissue fluid shift, forelimb loading and tail tension in tail-suspended rats. Physiologist 27:37-38
16. Laughlin MH, Armstrong RB, White J, Rouk K (1982) A method for using microspheres to measure muscle blood flow in exercising rats. J Appl Physiol 52:1629-1635
17. LeBlanc A, Marsh C, Evans H, Johnson P, Schneider V, Jhingram S (1985) Bone and muscle atrophy with suspension of the rat. J Appl Physiol 58:1669-1675
18. Martel E, Lacolley P, Champeroux P, Brisac AM, Laurent S, Cuche JL, Safar ME (1994) Early disturbance of baroreflex control of heart rate after tail suspension in conscious rats. J Appl Physiol 267:H2407-H2412
19. Martel E, Champeroux P, Lacolley P, Richard S, Safar M, Cuche JL (1996) Central hypervolemia in the conscious rat: a model of cardiovascular deconditioning. J Appl Physiol 80:1390-1396
20. McDonald KS, Delp MD, Fitts RH (1992a) Effect of hindlimb unweighting on tissue blood flow in the rat. J Appl Physiol 72:2210-2218
21. McDonald KS, Delp MD, Fitts RH (1992b) Fatigability and blood flow in the rat gastrocnemius-plantaris-soleus after hindlimb suspension. J Appl Physiol 73:1135-1140
22. Menard J, Catt KJ (1972) Measurement of renin activity, concentration and substrate in rat plasma by RIA of angiotensin I. Endocrinology 90:422-430
23. Morey ER (1979) Spaceflight and bone turnover: correlation with a new rat model of weightlessness. Bioscience 29:168-172
24. Musacchia XJ, Deavers DR, Meininger GA, Davis TP (1980) A model for hypokinesia: effects on muscle atrophy in the rat. J Appl Physiol 48:479-486
25. Oki S, Desaki J, Matsuda Y, Okumura H, Shibata T (1995) Capillaries with fenestrae in the rat soleus muscle after experimental limb immobilization. J Electron Microsc 44:307-310
26. Overton JM, Tipton CM (1990) Effect of hindlimb suspension on cardiovascular responses to sympathomimetics and lower body negative pressure. J Appl Physiol 68:355-362
27. Pannier BM, Lacolley P, Gharib C, London GM, Cuche JL, Duchier JL, Levy BI, Safar ME (1991) Twenty-four hours of bed-rest with head-down tilt: venous and arteriolar changes of the limbs. Am J Physiol 260:H1043-H1050
28. Popovic V, Popovic P, Honeycutt C (1982) Hormonal changes in antiorthostatic rats. Physiologist 25:77-78
29. Renkin EM (1979) Relation of capillary morphology to transport of fluid and large molecules: a review. Acta Physiol Scand 463:81-91
30. Shellock FG, Swan HJC, Rubin SA (1985) Early central venous pressure changes in the rat during two different levels of head-down suspension. Aviat Space Environ Med 56:791-795
31. Sudoh M, Waki H, Kawakami K, Sakai O, Saiki H (1994) Changes of blood volume distribution by postural changes in rats. J Gravit Physiol 1:139-140
32. Thornton WE, Moore TP, Pool SL (1987) Fluid shifts in weightlessness. Aviat Space Environ Med 58:A86-A90
33. Vernikos J, Dallman MF, Van Loon G, Keil LC (1991) Drug effects on orthostatic intolerance induced by bed-rest. J Clin Pharmacol 31:974-984
34. Wagner HN, Rhodes BA, Sasaki Y, Ryan JP (1969) Studies of the circulation with radioactive microspheres. Invest Radiol 4:374-386