Adrenocorticotropic hormone therapy for infantile spasms alters pyruvate metabolism in the central nervous system

Brain and Development

Volumn 20, Issue 5, 1998, Pages 312-318

  Miyazaki, Masahito ^a,c   Hashimoto, Toshiaki ^a,b   Yoneda, Yoshihiro ^a   Saijio, Takahiko ^a   Mori, Kenji ^a   Ito, Michinori ^a   Kuroda, Yasuhiro ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b National Center of Neurology and Psychiatry   (Japan)

^c Miyoshi Medical Clinic   (Japan)

Author keywords

Adrenocorticotropic hormone; Antiepileptic effect; Central nervous system; Infantile spasms; Pyruvate metabolism

Indexed keywords

CORTICOTROPIN; LACTIC ACID; PYRUVIC ACID; TETRACOSACTIDE ZINC PHOSPHATE;

ARTICLE; BLOOD LEVEL; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HORMONAL THERAPY; HUMAN; INFANT; INFANTILE SPASM; INTRAMUSCULAR DRUG ADMINISTRATION; LACTATE BLOOD LEVEL; MALE; METABOLISM; PRESCHOOL CHILD;

ADRENOCORTICOTROPIC HORMONE; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INFANT; LACTATES; MALE; PYRUVATES; SPASMS, INFANTILE; TREATMENT OUTCOME;

EID: 0031686273     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0387-7604(98)00041-2     Document Type: Article

References (24)

1. Sorel L, Dusaucy-Bauloye A. A propos de 21 cas d'hypsarhythmie de Gibbs. Son traitement spectaculaire par l'ACTH. Acta Neurol Psychiatr Belg 1958;58:130-141.
2. Hrachovy RA, Frost JD Jr, Kellaway P, Zion TE. Double-blind study of ACTH vs prednisone therapy in infantile spasms. J Pediatr 1983;103:641-645.
3. Prando R, Buzzo P, Cheli V, Melga P. ACTH 1-17 effects on intermediary metabolites in healthy subjects. Rie Clin Lab 1984;14:175-180.
4. Posner JB, Plum F. Independence of blood and cerebrospinal fluid lactate. Arch Neurol 1967;16:492-496.
5. Prick M, Gabreels F, Renier W, et al. Pyruvate dehydrogenase deficiency restricted to brain. Neurology 1981;31:398-404.
6. Rutledge SL, Snead OC, Kelly DR, et al. Pyruvate carboxylase deficiency: acute exacerbation after ACTH treatment of infantile spasms. Pediatr Neurol 1989;5:249-252.
7. Prasad AN, Stafstrom CF, Holmes GL. Alternative epilepsy therapies: the ketogenic diet, immunoglobulins, and steroids. Epilepsia 1996;37 (suppl 1):S81-95.
8. Brown GK, Hann EA, Kirby DM, et al. 'Cerebral' lactic acidosis: defects in pyruvate metabolism with profound brain damage and minimal systemic acidosis. Eur J Pediatr 1988;147:10-14.
9. Ito M, Okuno T, Fujii T, et al. ACTH therapy in infantile spasms: relationship between dose of ACTH and initial effect or long-term prognosis. Pediatr Neurol 1990;6:240-244.
10. Asanuma K, Ariga T, Aida N, et al. A new method for simultaneous autoanalysis of plasma levels of lactic acid and pyruvic acid by means of the oxidase system (in Japanese). Seibutsu Shiryou Bunseki (Tokyo) 1985;8:16-24.
11. Robinson BH. Lactic acidemia (disorders of pyruvate carboxylase, pyruvate dehydrogenase). In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease, seventh ed. New York: McGraw-Hill, 1995:1479-1499.
12. Riikonen R. Infantile spasms: some new theoretical aspects. Epilepsia 1983;24:159-168.
13. Baram TZ. Pathophysiology of massive infantile spasms: perspective on the putative role of the brain adrenal axis. Ann Neurol 1993;33:231-236.
14. Joels M, de Kloet ER. Control of neuronal excitability by corticosteroid hormones. Trends Neurosci 1992;15:25-29.
15. Silverstein F, Johnston MV. Cerebrospinal fluid monoamine metabolites in patients with infantile spasms. Neurology 1984;34:102-105.
16. Rilkonen RS. How do cryptogenic and symptomatic infantile spasms differ? Review of biochemical studies in Finnish patients. J Child Neurol 1996;11:383-388.
17. Izumi T, Imaizumi C, Ashida E, et al. Suppressive action of ACTH on growth hormone secretion in patients with infantile spasms. Brain Dev 1985;7:636-639.
18. Izumi T, Fukuyama Y. Influence of ACTH on serum hormone content and its anticonvulsant action towards infantile spasms. Life Sci 1984;34:1023-1028.
19. Jones CG, Hothi SK, Titheradge MA. Effect of dexamethasone on gluconeogenesis, pyruvate kinase, pyruvate carboxylase and pyruvate dehydrogenase flux in isolated hepatocytes. Biochem J 1993;289:821-828.
20. Riikonen R, Donner M. ACTH therapy in infantile spasms: side effects. Arch Dis Child 1980;55:664-672.
21. Deonna T, Voumard C. Reversible cerebral atrophy and corticotrophin. Lancet 1979;2:207.
22. Ito M, Takao T, Okuno T, Mikawa H. Sequential CT studies of 24 children with infantile spasms on ACTH therapy. Dev Med Child Neurol 1983;25:475-480.
23. Chiron C, Dulac O, Bluteau C, et al. Study of regional cerebral blood flow in West syndrome. Epilepsia 1993;34:707-715.
24. Futagi Y, Abe J, Ohtani K, Okamoto N. Cerebral blood flow during ACTH therapy: especially diurnal changes within the first week of therapy. Brain Dev 1988;10:164-168.