In vitro investigations of drug release and penetration - Enhancing effect of ultrasound on transmembrane transport of flufenamic acid

Experimental and Toxicologic Pathology

Volumn 50, Issue 4-6, 1998, Pages 450-452

  Hippius, M ^a   Smolenski, U ^b   Uhlemann, Ch ^c   Schreiber, U ^a   Hoffmann, A ^b  

^a Department of Clinical Pharmacology ^*  (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Drag release; Drug penetration; Flufenamic acid; Phonophoresis; Ultrasound, effect on transmembrane transport

Indexed keywords

FLUFENAMIC ACID;

ARTICLE; CELL MEMBRANE TRANSPORT; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; SKIN ABSORPTION; ULTRASOUND;

EID: 0031685811     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(98)80032-8     Document Type: Article

References (7)

1. TYLE P, AGRAWALA PDrug delivery by phonophoresis. Pharm Res 1989; 6: 355-361
2. QUILLIN WSPhonophoresis: a review of the literature and technique. Athletic Training 1980; 15: 109-110
3. BENSON HAF, MCELNAY JC, HARLAND R, HADGRAFT JInfluence of ultrasound on the percutaneous absorption of nicotinate esters. Pharmaceutical Research 1991; 8:204-208
4. HIPPIUS M, UHLEMANN CH, SMOLENSKI U, et al.Phonophorese von Salicylsäure in der Pharmakotherapie rheumatischer Erkrankungen, in: N. RIETBROCK: Die Haut als Transportorgan für Arzneistoffe. Steinkopffverlag Darmstadt, 1990,8.47-52
5. MENON, GK, BOMMANNAN DB, ELIAS PMHigh-frequency sonophoresis: Permeation pathways and structural basis for enhanced permeability. Skin Pharmacol. 1994; 7: 130-139
6. DELL H-D, FIEDLER J, JACOBI H, WäSCHE B: Zur Biochemie und Pharmakokinetik von Etofenamat, Arzneim.Forsch./Drug Res. 1977; 27(1): 1322-1325
7. KHIER AA, EI-SADEK M, BARAKA M:Spectrophotometric method for determination of flufenamic and mefenamic acid. Analyst 1987; 112: 1399-1403