Plasma and buffy coat concentration of 8-methoxypsoralen in patients treated with extracorporeal photopheresis

Experimental and Toxicologic Pathology

Volumn 50, Issue 4-6, 1998, Pages 397-401

  Balogh, A ^a,b   Merkel, U ^b   Looks, A ^a   Vollandt, R ^a   Wollina, U ^b  

^a Inst of Pharmacology and Toxicology   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

8 methoxypsoralen; Buffy coat; Extracorporal photopheresis; Furocoumarin, photosensitizing; Photopheresis, extracorporal; Plasma coat

Indexed keywords

FUROCOUMARIN; METHOXSALEN; PHOTOSENSITIZING AGENT;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; FEMALE; HUMAN; HUMAN CELL; LEUKAPHERESIS; MALE; ORAL DRUG ADMINISTRATION; PUVA; SYSTEMIC SCLEROSIS; T CELL LYMPHOMA; ULTRAVIOLET A RADIATION;

EID: 0031685810     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(98)80025-0     Document Type: Article

References (16)

1. STERN RS, PARRISH JA and JOHNSON B: Photochemotherapy ; in Hasan Muchtar (ed) Pharmacology of the skin. Boca Raton, SLA; CRC press 1992, pp 505-541.
2. EDELSON R, BERGER C, GASPARRO F, et al.: Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. N Engl J Med 1987; 316: 297-303.
3. FAHRMEIR L, HAMERLE A (ed): Multivariante statistische Verfahren. Walter de Gruyter Berlin - New York 1984 p 195.
4. SUSANTO F, HUMFILD S, REINAUER H, MESCHLN'G R: High performance liquid chromatography measurement of 8-methoxypsoralen in plasma. Chromatographia 1986; 21: 443-446.
5. SCHMID J, PROX A, ZIPP H, Koss FW: The use of stable isotopes to prove the saturable first-pass-effect of methoxsalen. Biomed Mass Spectro 1980; 7: 560-564.
6. BRICKL R, SCHMID J, Koss FW: Pharmacokinetics and pharmacodynamics of psoralens after oral administration: Considerations and Conclusion. Natl Cancer Inst Monogr 1984; 66: 63-67.
7. MARRAKCHI S, DECLOQUEMENT L, POLLET P, BRIAND G, LOESCHE C, BOCQUET JL, DEGAND P: Variation in 8-methoxypsoralen profiles during long-term psoralen plus ultraviolet A therapy and correlations between serum 8-Methoxypsoralen levels and chromametric parameters. Photodermatol Photoimmunol Photomed 1991; 8: 206-211.
8. TINEL M, BELGHIHI J, DESCATOIRE V et al.: Inactivation of human liver Cytochrome P-450 by the drug methoxysalen and other psoralen derivates. Bichem Pharmacol 1987; 36: 951-955.
9. APSELOFF G, SHEPARD DR, CHAMBERS MA, NAWOOT S, MAYS DC, GERBER N: Inhibiton and induction of theophylline metabolism by 8-methoxypsoralen. In vivo study in rats and humans. Drug Metab Dispos Biol Fate Chem 1990; 13: 298-303.
10. LABBE G, DESCATOIRE, V, LETTERON P, DEGOTT C, TINEL M, LARREY D, CARRION-PAVLOV Y, GENEVE J, AMOUYAL G, PESSAYRE D: The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice. Biochem Pharmacol 1987; 36: 907-914.
11. SCHÄFER-KORUNG M, KORUNG HcH: Intraindividual variations of 8-methoxypsoralen plasma levels. Arch Dermatol Res 1982; 272: 1-7.
12. HEALD PW, PEREZ MI, GASPARRO FP: Dosage guidelines: extracorporeal photochemotherapy (photopheresis) (Letter). Arch Dermatol 1990; 126: 1369.
13. HERFST MJ, DE WOLFF FA: Intraindividual variability in 8-methoxypsoralen kinetics and effect in psoriatic patients. Pharmacol Ther 1983; 34: 117-124.
14. EHRSSON H, NILSSON SO, EHRNEBO M, INGER W, WENNERSTEN G: Effect of food on kinetics of 8-methoxsalen. Pharmacol Ther 1979; 25: 167-171.
15. THOMSEN NB, ANGELD HR, KNUDSEN EA: The influence of food on 8-methoxypsoralen serum concentration and minimal phototoxic dose. Br J Dermatol 1992; 127: 620-624
16. KNOBLER RM, TRAUTINGER F, GRANINGER W, MACHEINER W, GRUENWALD CH, NEUMANN R, RAMER W: Parenteral administration of 8-methoxy- psoralen in photopheresis. J Am Acad Dermatol 1993; 28: 580-584.