Clinical characterization of polymorphisms in the sulphonylurea receptor 1 gene in Japanese subjects with Type 2 diabetes mellitus

Diabetic Medicine

Volumn 15, Issue 10, 1998, Pages 826-829

  Ishiyama Shigemoto, S ^a   Yamada, K ^a   Yuan, X ^a   Koyama, W ^b   Nonaka, K ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAPANESE RED CROSS KUMAMOTO HOSPITAL   (Japan)

Author keywords

Obesity; Sulphonylurea receptor; Type 2 diabetes mellitus

Indexed keywords

DRUG RECEPTOR; POTASSIUM CHANNEL; SULFONYLUREA;

ADULT; AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; DNA POLYMORPHISM; EXON; FAMILY HISTORY; FEMALE; GLUCOSE TOLERANCE; HUMAN; INTRON; JAPAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEIC ACID BASE SUBSTITUTION; OBESITY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ATP-BINDING CASSETTE TRANSPORTERS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DNA; ELECTROPHORESIS, AGAR GEL; EXONS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INTRONS; JAPAN; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, DRUG; VARIATION (GENETICS);

EID: 0031684712     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9136(199810)15:10<826::AID-DIA685>3.0.CO;2-H     Document Type: Article

References (10)

1. + channels in pancreatic ß-cells. Nature 1984; 311: 271-273.
2. Ashcroft FM, Harrison DE, Ashcroft SJH. Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells. Nature 1984; 312: 446-448.
3. Misler S, Falke LC, Gillis K, McDaniel ML. A metabolite-regulated potassium channel in rat pancreatic B cells. Proc Natl Acad Sci USA 1986; 83: 7119-7123.
4. KATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 1995; 270: 1166-1170.
5. Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP, Boyd AE, Gonzalez G, et al. Cloning of the β cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 1995; 268: 423-426.
6. + channel in insulin-secreting cells. J Biol Chem 1987; 262: 15840-15844.
7. Thomas PM, Cote GJ, Wohllk N, Haddad B, Mathew PM, Rabl W, et al. Mutation in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 1995; 268: 426-429.
8. Inoue H, Ferrer J, Welling CM, Elbein SC, Hoffman M, Mayorga R, et al. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians. Diabetes 1996; 45: 825-831.
9. Hani EH, Clement K, Velho G, Vionnet N, Hager J, Philippi A, et al. Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians. Diabetes 1997; 46: 688-694.
10. + channel and linkage studies with NIDDM in Japanese. Diabetes 1996; 45: 267-269.