Inhibition of triazolam hydroxylation by ketoconazole, itraconazole, hydroxyitraconazole and fluconazole in-vitro

Pharmacy and Pharmacology Communications

Volumn 4, Issue 9, 1998, Pages 443-445

  Von Moltke, Lisa L ^a   Greenblatt, David J ^a   Duan, Su Xiang ^a   Harmatz, Jerold S ^a   Shader, Richard I ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; FLUCONAZOLE; HYDROXYITRACONAZOLE; ITRACONAZOLE; KETOCONAZOLE; TRIAZOLAM;

ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HYDROXYLATION; DRUG POTENCY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MICROSOME;

EID: 0031682181     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Back, D. J., Tjia, J. F. (1991) Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes. Br. J. Clin. Pharmacol. 32: 624-626
2. Barone, J. A., Koh, J. G., Bierman, R. H., Colaizzi, J. L., Swanson, K. A., Gaffar, M. C., Moskovitz, B. L., Mechlinski, B. W., van de Velde, V. (1993) Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy male volunteers. Antimicrob. Agents Chemother. 37: 778-784
3. Heykants, J., Michiels, M., Meuldermans, W., Monbaliu, J., Lavrijsen, K., van Peer, A., Levron, J. C., Woestenborghs, R., Cauwenbergh, G. (1987). The pharmacokinetics of itraconazole in animals and man; an overview. In: Fromtling, R. (ed.) Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents. J. R. Prous Science Publishers, Barcelona, pp 223-249
4. Kronbach, T., Mathys, D., Umeno, M., Gonzalez, F. J., Meyer, U. A. (1989) Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Mol. Pharmacol. 36: 89-96
5. Luurila, H., Kivistö, K. T., Neuvonen, P. J. (1998) Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem. Euro. J. Clin. Pharmacol. 54: 336-340
6. Venkatakrishnan, K., Greenblatt, D. J., von Moltke, L. L., Schmider, J., Harmatz, J. S., Shader, R. I. (1998a) Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4. J. Clin. Pharmacol. 38: 112-121
7. Venkatakrishnan, K., von Moltke, L. L., Duan, S. X., Fleishaker, J. C., Shader, R. I., Greenblatt, D. J. (1998b) Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J. Pharm. Pharmacol. 50: 265-274
8. von Moltke, L. L., Greenblatt, D. J., Cotreau-Bibbo, M. M., Harmatz, J. S., Shader, R. I. (1994) Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine. Br. J. Clin. Pharmacol. 38: 23-31
9. von Moltke, L. L., Greenblatt, D. J., Schmider, J., Harmatz, J. S., Shader, R. I. (1995) Metabolism of drugs by cytochrome P450 3A isoforms: implications for drug interactions in psychopharmacology. Clin. Pharmacokinet. 29 (Suppl 1): 33-43
10. von Moltke, L. L., Greenblatt, D. J., Harmatz, J. S., Duan, S. X., Harrel, L. M., Cotreau-Bibbo, M. M., Pritchard, G. A., Wright, C. E., Shader, R. I. (1996a) Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors, and clinical confirmation of a predicted interaction with ketoconazole. J. Pharmacol. Exp. Ther. 276: 370-379
11. von Moltke, L. L., Greenblatt, D. J., Schmider, J., Duan, S. X., Wright, C. E., Harmatz, J. S., Shader, R. I. (1996b) Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole anti-fungal agents. J. Clin. Pharmacol. 36: 783-791
12. von Moltke, L. L., Greenblatt, D. J., Grassi, J. M., Granda, B. W., Duan, S. X., Fogelman, S. M., Daily, J. P., Harmatz, J. S. Shader, R. I. (1998a) Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir. J. Clin. Pharmacol. 38: 106-111
13. von Moltke, L. L., Greenblatt, D. J., Schmider, J., Wright, C. E., Harmatz, J. S., Shader, R. I. (1998b) In vitro approaches to predicting drug interactions in vivo. Biochem. Pharmacol. 55: 113-122