Presentation of non-peptide antigens, in particular drugs, to specific T cells

Clinical and Experimental Allergy, Supplement

Volumn 28, Issue 4, 1998, Pages 7-11

  Von Greyerz, S ^a   Zanni, M ^a   Schnyder, B ^a   Pichler, W J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Antigen presentation; Drug allergy; Non peptide antigens; T cells

Indexed keywords

ANTIGEN; CARRIER PROTEIN; DRUG; MAJOR HISTOCOMPATIBILITY ANTIGEN; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; DRUG HYPERSENSITIVITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANTIGEN PRESENTATION; ANTIGENS; DRUG HYPERSENSITIVITY; HUMANS; PHARMACEUTICAL PREPARATIONS; T-LYMPHOCYTES;

EID: 0031679466     PISSN: 09602178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Porcelli SA, Morita CT, Modlin RL. T cell recognition of nonpeptide antigens. Curr Opin Immunol 1996; 8: 510-6.
2. Sieling PA, Chatterjee D, Porcelli SA et al. CD1 restricted T cell recognition of microbial lipoglycans. Sci 1995; 269: 227-30.
3. Morita CT, Beckman EM, Bukowski JF et al. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gd T cells. Immunity 1995; 3: 495-507.
4. Corinti S, De Palma R, Fontana A et al. Major histocompatibility complex-independent recognition of a distinctive pollen antigen, most likely a carbohydrate, by human CD8+ a/b T cells. J Exp Med 1997; 186: 899-908.
5. Kapsenberg ML, Wierenga EA, Stiekema FEM, Tiggelman AMBC, Bos JD. Th1 lymphokine production profiles of nickel-specific CD4+ lymphocyte clones from nickel contact allergic and non-allergic individuals. J Invest Dermatol 1991; 98: 59-63.
6. Moulon C, Vollmer J, Weltzien HU. Characterization of processing requirements and metal cross-reactivities in T cell clones from patients with allergic contact dermatitis to nickel. Eur J Immunol 1995; 25: 3308-15.
7. Griem PE, Panthel K, Kalbacher H, Gleichmann E. Alteration of a model antigen by Au (III) leads to T cell sensitization to cryptic peptides. Eur J Immunol 1996; 26: 279-87.
8. Nyffeler B, Pichler WJ. The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin Exp Allergy 1997; 27: 175-81.
9. Hertl M, Geisel J, Boecker C, Merk HF. Selective generation of CD8+ T cell clones from the peripheral blood of patients with bullous cutaneous reactions to beta-lactam antibiotics. Br J Dermatol 1993; 128: 619-26.
10. Mauri-Hellweg D, Bettens F, Mauri D, Brander C, Hunziker T, Pichler WJ. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin and carbamazepine. J Immunol 1995; 155: 462-72.
11. Brander C, Mauri-Hellweg D, Bettens F et al. Heterogenous T cell responses to b-lactam modified self structures are observed in penicillin allergic individuals. J Immunol 1995; 155: 2670-8.
12. Zanni MP, Mauri-Hellweg D, Brander C et al. Characterization of lidocaine specific Tcells. J Immunol 1997; 158: 1139-48.
13. Schnyder B, Mauri-Hellweg D, Zanni M, Bettens F, Pichler WJ. Direct, MHC-dependent presentation of the drug sulfamethoxazole to human ab T cell clones. J Clin Invest 1997; 100: 136-41.
14. Landsteiner K, Jacoby J. Studies on the sensitization of animals with simple chemical compounds, II. J Exp Med 1936; 64: 625.
15. Weltzien HU, Moulon C, Martin S et al. T cell immune response to haptens: Structural models for allergic and autoimmune reactions. Toxicol 1996; 107: 141-51.
16. de Weck AL, Scheider CH, Gutersohn J. The role of penicilloylated proten impurities, penicillin polymers and dimers in penicillin allergy. Int Arch Allergy Appl Immunol 1968; 33: 535-42.
17. Radovan E, Bauer T, Tongio MM, Kalbacher H, Weltzien HU. Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy. Eur J Immunol 1997; 27: 1303-7.
18. + T cell clones. Intern Immunol 1998; in press.
19. Kohler J, Hartmann U, Grimm R, Plugenfelder U, Weltzien HU. Carrier-independent hapten recognition and promiscous MHC restriction by CD4 T cells induced by trinitrophenylated peptides. J Immunol 1997; 158: 591-7.
20. Jullien D, Stenger S, Ernst WA, Modlin RL. Perspecitves Series: Host/pathogen interactions. CD1 presentation of microbial nonpeptide antigens to T cells. J Clin Invest 1997; 99: 2071-4.